BRENDA - Enzyme Database show

Thromboxane synthase expression and thromboxane A2 production in the atherosclerotic lesion

Gabrielsen, A.; Qiu, H.; Baeck, M.; Hamberg, M.; Hemdahl, A.L.; Agardh, H.; Folkersen, L.; Swedenborg, J.; Hedin, U.; Paulsson-Berne, G.; Haeggstroem, J.Z.; Hansson, G.K.; J. Mol. Med. 88, 795-806 (2010)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.5
furegrelate
-
Homo sapiens
5.3.99.5
furegrelate
-
Mus musculus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.5
prostaglandin H2
Mus musculus
-
thromboxane A2 + ?
-
-
?
5.3.99.5
prostaglandin H2
Homo sapiens
-
thromboxane A2 + ?
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.5
Homo sapiens
-
-
-
5.3.99.5
Mus musculus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.5
aorta
TXAS is expressed in the atherosclerotic lesion, associated with increased inflammatory cells, in particular M2 polarized macrophages
Homo sapiens
-
5.3.99.5
aorta
TXAS is expressed in the atherosclerotic lesion, associated with increased inflammatory cells, in particular M2 polarized macrophages
Mus musculus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.5
prostaglandin H2
-
705219
Mus musculus
thromboxane A2 + ?
-
-
-
?
5.3.99.5
prostaglandin H2
-
705219
Homo sapiens
thromboxane A2 + ?
-
-
-
?
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.5
furegrelate
-
Homo sapiens
5.3.99.5
furegrelate
-
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.5
prostaglandin H2
Mus musculus
-
thromboxane A2 + ?
-
-
?
5.3.99.5
prostaglandin H2
Homo sapiens
-
thromboxane A2 + ?
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.5
aorta
TXAS is expressed in the atherosclerotic lesion, associated with increased inflammatory cells, in particular M2 polarized macrophages
Homo sapiens
-
5.3.99.5
aorta
TXAS is expressed in the atherosclerotic lesion, associated with increased inflammatory cells, in particular M2 polarized macrophages
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.5
prostaglandin H2
-
705219
Mus musculus
thromboxane A2 + ?
-
-
-
?
5.3.99.5
prostaglandin H2
-
705219
Homo sapiens
thromboxane A2 + ?
-
-
-
?
Expression
EC Number
Organism
Commentary
Expression
5.3.99.5
Homo sapiens
inhibition of platelet TXA2 generation (acetylsalicylic acid), lowering of cholesterol (statins), inhibition of platelet aggregation (clopidogrel), or promoting vasodilatation (dipyridamole) has no effect on TXAS mRNA expression levels
additional information
5.3.99.5
Mus musculus
inhibition of platelet TXA2 generation (acetylsalicylic acid), lowering of cholesterol (statins), inhibition of platelet aggregation (clopidogrel), or promoting vasodilatation (dipyridamole) has no effect on TXAS mRNA expression levels
additional information
5.3.99.5
Homo sapiens
TXAS increases in atherosclerotic lesions of patients with recent symptoms of thrombotic events
up
5.3.99.5
Mus musculus
TXAS mRNA expression is increased within the vascular wall in mouse models of atherosclerosis with advanced lesions
up
Expression (protein specific)
EC Number
Organism
Commentary
Expression
5.3.99.5
Homo sapiens
inhibition of platelet TXA2 generation (acetylsalicylic acid), lowering of cholesterol (statins), inhibition of platelet aggregation (clopidogrel), or promoting vasodilatation (dipyridamole) has no effect on TXAS mRNA expression levels
additional information
5.3.99.5
Mus musculus
inhibition of platelet TXA2 generation (acetylsalicylic acid), lowering of cholesterol (statins), inhibition of platelet aggregation (clopidogrel), or promoting vasodilatation (dipyridamole) has no effect on TXAS mRNA expression levels
additional information
5.3.99.5
Homo sapiens
TXAS increases in atherosclerotic lesions of patients with recent symptoms of thrombotic events
up
5.3.99.5
Mus musculus
TXAS mRNA expression is increased within the vascular wall in mouse models of atherosclerosis with advanced lesions
up