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Literature summary extracted from

  • Gabrielsen, A.; Qiu, H.; Baeck, M.; Hamberg, M.; Hemdahl, A.L.; Agardh, H.; Folkersen, L.; Swedenborg, J.; Hedin, U.; Paulsson-Berne, G.; Haeggstroem, J.Z.; Hansson, G.K.
    Thromboxane synthase expression and thromboxane A2 production in the atherosclerotic lesion (2010), J. Mol. Med., 88, 795-806.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.3.99.5 furegrelate
-
Homo sapiens
5.3.99.5 furegrelate
-
Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.99.5 prostaglandin H2 Mus musculus
-
thromboxane A2
-
?
5.3.99.5 prostaglandin H2 Homo sapiens
-
thromboxane A2
-
?

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.5 Homo sapiens
-
-
-
5.3.99.5 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.99.5 aorta TXAS is expressed in the atherosclerotic lesion, associated with increased inflammatory cells, in particular M2 polarized macrophages Mus musculus
-
5.3.99.5 aorta TXAS is expressed in the atherosclerotic lesion, associated with increased inflammatory cells, in particular M2 polarized macrophages Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.5 prostaglandin H2
-
Mus musculus thromboxane A2
-
?
5.3.99.5 prostaglandin H2
-
Homo sapiens thromboxane A2
-
?

Synonyms

EC Number Synonyms Comment Organism
5.3.99.5 thromboxane synthase
-
Mus musculus
5.3.99.5 thromboxane synthase
-
Homo sapiens
5.3.99.5 TXAS
-
Mus musculus
5.3.99.5 TXAS
-
Homo sapiens

Expression

EC Number Organism Comment Expression
5.3.99.5 Mus musculus inhibition of platelet TXA2 generation (acetylsalicylic acid), lowering of cholesterol (statins), inhibition of platelet aggregation (clopidogrel), or promoting vasodilatation (dipyridamole) has no effect on TXAS mRNA expression levels additional information
5.3.99.5 Homo sapiens inhibition of platelet TXA2 generation (acetylsalicylic acid), lowering of cholesterol (statins), inhibition of platelet aggregation (clopidogrel), or promoting vasodilatation (dipyridamole) has no effect on TXAS mRNA expression levels additional information
5.3.99.5 Homo sapiens TXAS increases in atherosclerotic lesions of patients with recent symptoms of thrombotic events up
5.3.99.5 Mus musculus TXAS mRNA expression is increased within the vascular wall in mouse models of atherosclerosis with advanced lesions up