BRENDA - Enzyme Database show

C-reactive protein impairs coronary arteriolar dilation to prostacyclin synthase activation: role of peroxynitrite

Hein, T.W.; Qamirani, E.; Ren, Y.; Kuo, L.; J. Mol. Cell. Cardiol. 47, 196-202 (2009)

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
5.3.99.4
medicine
by impairing prostacyclin synthase function, and thus PGI2 release, C-reactive protein, CRP, could promote endothelial dysfunction and participate in the development of coronary artery disease
Sus scrofa
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.4
additional information
proinflammatory C-reactive protein, CRP, selectively inhibits endothelium-dependent PGI2-induced dilation of coronary arterioles through peroxynitrite-mediated tyrosine nitration of prostacyclin synthase
Sus scrofa
5.3.99.4
trans-2-phenyl cyclopropylamine
-
Sus scrofa
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
5.3.99.4
52000
-
determined by SDS-PAGE and Western Blot analysis
Sus scrofa
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.4
Prostaglandin H2
Sus scrofa
-
Prostaglandin I2
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.4
Sus scrofa
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.4
arteriole
coronary arteriole
Sus scrofa
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.4
Prostaglandin H2
-
705205
Sus scrofa
Prostaglandin I2
-
-
-
?
Application (protein specific)
EC Number
Application
Commentary
Organism
5.3.99.4
medicine
by impairing prostacyclin synthase function, and thus PGI2 release, C-reactive protein, CRP, could promote endothelial dysfunction and participate in the development of coronary artery disease
Sus scrofa
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.4
additional information
proinflammatory C-reactive protein, CRP, selectively inhibits endothelium-dependent PGI2-induced dilation of coronary arterioles through peroxynitrite-mediated tyrosine nitration of prostacyclin synthase
Sus scrofa
5.3.99.4
trans-2-phenyl cyclopropylamine
-
Sus scrofa
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
5.3.99.4
52000
-
determined by SDS-PAGE and Western Blot analysis
Sus scrofa
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.4
Prostaglandin H2
Sus scrofa
-
Prostaglandin I2
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.4
arteriole
coronary arteriole
Sus scrofa
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.4
Prostaglandin H2
-
705205
Sus scrofa
Prostaglandin I2
-
-
-
?