EC Number | Application | Comment | Organism |
---|---|---|---|
5.3.99.4 | medicine | by impairing prostacyclin synthase function, and thus PGI2 release, C-reactive protein, CRP, could promote endothelial dysfunction and participate in the development of coronary artery disease | Sus scrofa |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
5.3.99.4 | additional information | proinflammatory C-reactive protein, CRP, selectively inhibits endothelium-dependent PGI2-induced dilation of coronary arterioles through peroxynitrite-mediated tyrosine nitration of prostacyclin synthase | Sus scrofa | |
5.3.99.4 | trans-2-phenyl cyclopropylamine | - |
Sus scrofa |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
5.3.99.4 | 52000 | - |
determined by SDS-PAGE and Western Blot analysis | Sus scrofa |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.3.99.4 | Prostaglandin H2 | Sus scrofa | - |
Prostaglandin I2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
5.3.99.4 | Sus scrofa | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
5.3.99.4 | arteriole | coronary arteriole | Sus scrofa | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.3.99.4 | Prostaglandin H2 | - |
Sus scrofa | Prostaglandin I2 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
5.3.99.4 | PGI2 synthase | - |
Sus scrofa |
5.3.99.4 | PGI2-S | - |
Sus scrofa |
5.3.99.4 | prostacyclin synthase | - |
Sus scrofa |