EC Number | Cloned (Comment) | Organism |
---|---|---|
1.5.1.3 | expression of wild-type and mutant enzymes in Escherichia coli strain BL21 (DE3) | Homo sapiens |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
1.5.1.3 | enzyme mutant Q35S/N64S in complex with NADPH and inhibitor N-(4-[(2-amino-6-ethyl-4-oxo-3,4-dihydrothieno[2,3-d ]pyrimidin-5-yl)thio]benzoyl)-L-glutamic acid, and enzyme mutant Q35K in complex with NADPH and inhibitor N-{4-[(2-amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d ]pyrimidin-5-yl)thio]benzoyl}-L-glutamic acid, X-ray diffraction structure determination and analysis at 1.2-1.5 A resolution | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.5.1.3 | 2-amino-5-[(2,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d ]pyrimidin-4(3H)-one | - |
Escherichia coli | |
1.5.1.3 | 2-amino-5-[(2,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d ]pyrimidin-4(3H)-one | - |
Homo sapiens | |
1.5.1.3 | 2-amino-5-[(2,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d ]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
1.5.1.3 | 2-amino-5-[(2-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d ]pyrimidin-4(3H)-one | - |
Escherichia coli | |
1.5.1.3 | 2-amino-5-[(2-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d ]pyrimidin-4(3H)-one | - |
Homo sapiens | |
1.5.1.3 | 2-amino-5-[(2-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d ]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
1.5.1.3 | 2-amino-5-[(3,4-dichlorophenyl)thio]-6-ethylthieno[2,3-d ]pyrimidin-4(3H)-one | - |
Escherichia coli | |
1.5.1.3 | 2-amino-5-[(3,4-dichlorophenyl)thio]-6-ethylthieno[2,3-d ]pyrimidin-4(3H)-one | - |
Homo sapiens | |
1.5.1.3 | 2-amino-5-[(3,4-dichlorophenyl)thio]-6-ethylthieno[2,3-d ]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
1.5.1.3 | 2-amino-5-[(3,5-dichlorophenyl)sulfanyl]-6-ethylthieno[2,3-d ]-pyrimidin-4(3H)-one | - |
Escherichia coli | |
1.5.1.3 | 2-amino-5-[(3,5-dichlorophenyl)sulfanyl]-6-ethylthieno[2,3-d ]-pyrimidin-4(3H)-one | - |
Homo sapiens | |
1.5.1.3 | 2-amino-5-[(3,5-dichlorophenyl)sulfanyl]-6-ethylthieno[2,3-d ]-pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
1.5.1.3 | 2-amino-5-[(3,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d ]pyrimidin-4(3H)-one | - |
Escherichia coli | |
1.5.1.3 | 2-amino-5-[(3,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d ]pyrimidin-4(3H)-one | - |
Homo sapiens | |
1.5.1.3 | 2-amino-5-[(3,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d ]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
1.5.1.3 | 2-amino-5-[(3-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d ]pyrimidin-4(3H)-one | - |
Escherichia coli | |
1.5.1.3 | 2-amino-5-[(3-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d ]pyrimidin-4(3H)-one | - |
Homo sapiens | |
1.5.1.3 | 2-amino-5-[(3-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d ]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
1.5.1.3 | 2-amino-5-[(4-bromophenyl)sulfanyl]-6-ethylthieno[2,3-d ]pyrimidin-4(3H)-one | - |
Escherichia coli | |
1.5.1.3 | 2-amino-5-[(4-bromophenyl)sulfanyl]-6-ethylthieno[2,3-d ]pyrimidin-4(3H)-one | - |
Homo sapiens | |
1.5.1.3 | 2-amino-5-[(4-bromophenyl)sulfanyl]-6-ethylthieno[2,3-d ]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
1.5.1.3 | 2-amino-5-[(4-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Escherichia coli | |
1.5.1.3 | 2-amino-5-[(4-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Homo sapiens | |
1.5.1.3 | 2-amino-5-[(4-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
1.5.1.3 | 2-amino-6-ethyl-5-(2-naphthylthio)thieno[2,3-d ]pyrimidin-4(3H)-one | - |
Escherichia coli | |
1.5.1.3 | 2-amino-6-ethyl-5-(2-naphthylthio)thieno[2,3-d ]pyrimidin-4(3H)-one | - |
Homo sapiens | |
1.5.1.3 | 2-amino-6-ethyl-5-(2-naphthylthio)thieno[2,3-d ]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
1.5.1.3 | 2-amino-6-ethyl-5-(phenylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | - |
Escherichia coli | |
1.5.1.3 | 2-amino-6-ethyl-5-(phenylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | - |
Homo sapiens | |
1.5.1.3 | 2-amino-6-ethyl-5-(phenylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
1.5.1.3 | 2-amino-6-ethyl-5-(pyridin-4-ylsulfanyl)thieno[2,3-d ]pyrimidin-4(3H)-one | - |
Escherichia coli | |
1.5.1.3 | 2-amino-6-ethyl-5-(pyridin-4-ylsulfanyl)thieno[2,3-d ]pyrimidin-4(3H)-one | - |
Homo sapiens | |
1.5.1.3 | 2-amino-6-ethyl-5-(pyridin-4-ylsulfanyl)thieno[2,3-d ]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
1.5.1.3 | 2-amino-6-ethyl-5-[(4-fluorophenyl)sulfanyl]thieno[2,3-d ]pyrimidin-4(3H)-one | - |
Escherichia coli | |
1.5.1.3 | 2-amino-6-ethyl-5-[(4-fluorophenyl)sulfanyl]thieno[2,3-d ]pyrimidin-4(3H)-one | - |
Homo sapiens | |
1.5.1.3 | 2-amino-6-ethyl-5-[(4-fluorophenyl)sulfanyl]thieno[2,3-d ]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
1.5.1.3 | 2-amino-6-ethyl-5-[(4-nitrophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | - |
Escherichia coli | |
1.5.1.3 | 2-amino-6-ethyl-5-[(4-nitrophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | - |
Homo sapiens | |
1.5.1.3 | 2-amino-6-ethyl-5-[(4-nitrophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
1.5.1.3 | methotrexate | - |
Escherichia coli | |
1.5.1.3 | methotrexate | - |
Homo sapiens | |
1.5.1.3 | methotrexate | - |
Toxoplasma gondii | |
1.5.1.3 | N-(4-[(2-amino-6-ethyl-4-oxo-3,4-dihydrothieno[2,3-d ]pyrimidin-5-yl)thio]benzoyl)-L-glutamic acid | - |
Escherichia coli | |
1.5.1.3 | N-(4-[(2-amino-6-ethyl-4-oxo-3,4-dihydrothieno[2,3-d ]pyrimidin-5-yl)thio]benzoyl)-L-glutamic acid | - |
Homo sapiens | |
1.5.1.3 | N-(4-[(2-amino-6-ethyl-4-oxo-3,4-dihydrothieno[2,3-d ]pyrimidin-5-yl)thio]benzoyl)-L-glutamic acid | - |
Toxoplasma gondii | |
1.5.1.3 | N-(4-[(2-amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d ]pyrimidin-5-yl)thio]benzoyl)-L-glutamic acid | - |
Escherichia coli | |
1.5.1.3 | N-(4-[(2-amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d ]pyrimidin-5-yl)thio]benzoyl)-L-glutamic acid | - |
Homo sapiens | |
1.5.1.3 | N-(4-[(2-amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d ]pyrimidin-5-yl)thio]benzoyl)-L-glutamic acid | - |
Toxoplasma gondii | |
1.5.1.3 | nolatrexed | - |
Escherichia coli | |
1.5.1.3 | nolatrexed | - |
Homo sapiens | |
1.5.1.3 | nolatrexed | - |
Toxoplasma gondii | |
1.5.1.3 | pemetrexed | - |
Escherichia coli | |
1.5.1.3 | pemetrexed | - |
Homo sapiens | |
1.5.1.3 | pemetrexed | - |
Toxoplasma gondii | |
1.5.1.3 | permetrexed | - |
Escherichia coli | |
1.5.1.3 | permetrexed | - |
Homo sapiens | |
1.5.1.3 | permetrexed | - |
Toxoplasma gondii | |
1.5.1.3 | piritrexim | - |
Escherichia coli | |
1.5.1.3 | piritrexim | - |
Homo sapiens | |
1.5.1.3 | piritrexim | - |
Toxoplasma gondii | |
1.5.1.3 | plevitrexed | - |
Escherichia coli | |
1.5.1.3 | plevitrexed | - |
Homo sapiens | |
1.5.1.3 | plevitrexed | - |
Toxoplasma gondii | |
1.5.1.3 | raltitrexed | - |
Escherichia coli | |
1.5.1.3 | raltitrexed | - |
Homo sapiens | |
1.5.1.3 | raltitrexed | - |
Toxoplasma gondii | |
1.5.1.3 | trimethoprim | - |
Escherichia coli | |
1.5.1.3 | trimethoprim | - |
Homo sapiens | |
1.5.1.3 | trimethoprim | - |
Toxoplasma gondii | |
1.5.1.3 | trimetrexate | - |
Escherichia coli | |
1.5.1.3 | trimetrexate | - |
Homo sapiens | |
1.5.1.3 | trimetrexate | - |
Toxoplasma gondii | |
2.1.1.45 | 10-propargyl-5,8-dideazafolate | - |
Escherichia coli | |
2.1.1.45 | 10-propargyl-5,8-dideazafolate | - |
Homo sapiens | |
2.1.1.45 | 10-propargyl-5,8-dideazafolate | - |
Toxoplasma gondii | |
2.1.1.45 | 2-amino-5-[(2,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Escherichia coli | |
2.1.1.45 | 2-amino-5-[(2,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Homo sapiens | |
2.1.1.45 | 2-amino-5-[(2,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
2.1.1.45 | 2-amino-5-[(2-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Escherichia coli | |
2.1.1.45 | 2-amino-5-[(2-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Homo sapiens | |
2.1.1.45 | 2-amino-5-[(2-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
2.1.1.45 | 2-amino-5-[(3,4-dichlorophenyl)thio]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Escherichia coli | |
2.1.1.45 | 2-amino-5-[(3,4-dichlorophenyl)thio]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Homo sapiens | |
2.1.1.45 | 2-amino-5-[(3,4-dichlorophenyl)thio]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
2.1.1.45 | 2-amino-5-[(3,5-dichlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]-pyrimidin-4(3H)-one | - |
Escherichia coli | |
2.1.1.45 | 2-amino-5-[(3,5-dichlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]-pyrimidin-4(3H)-one | - |
Homo sapiens | |
2.1.1.45 | 2-amino-5-[(3,5-dichlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]-pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
2.1.1.45 | 2-amino-5-[(3,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Escherichia coli | |
2.1.1.45 | 2-amino-5-[(3,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Homo sapiens | |
2.1.1.45 | 2-amino-5-[(3,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
2.1.1.45 | 2-amino-5-[(3-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Escherichia coli | |
2.1.1.45 | 2-amino-5-[(3-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Homo sapiens | |
2.1.1.45 | 2-amino-5-[(3-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
2.1.1.45 | 2-amino-5-[(4-bromophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Escherichia coli | |
2.1.1.45 | 2-amino-5-[(4-bromophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Homo sapiens | |
2.1.1.45 | 2-amino-5-[(4-bromophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
2.1.1.45 | 2-amino-5-[(4-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Escherichia coli | |
2.1.1.45 | 2-amino-5-[(4-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Homo sapiens | |
2.1.1.45 | 2-amino-5-[(4-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
2.1.1.45 | 2-amino-6-ethyl-5-(2-naphthylthio)thieno[2,3-d]pyrimidin-4(3H)-one | - |
Escherichia coli | |
2.1.1.45 | 2-amino-6-ethyl-5-(2-naphthylthio)thieno[2,3-d]pyrimidin-4(3H)-one | - |
Homo sapiens | |
2.1.1.45 | 2-amino-6-ethyl-5-(2-naphthylthio)thieno[2,3-d]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
2.1.1.45 | 2-amino-6-ethyl-5-(phenylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | - |
Escherichia coli | |
2.1.1.45 | 2-amino-6-ethyl-5-(phenylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | - |
Homo sapiens | |
2.1.1.45 | 2-amino-6-ethyl-5-(phenylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
2.1.1.45 | 2-amino-6-ethyl-5-(pyridin-4-ylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | - |
Escherichia coli | |
2.1.1.45 | 2-amino-6-ethyl-5-(pyridin-4-ylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | - |
Homo sapiens | |
2.1.1.45 | 2-amino-6-ethyl-5-(pyridin-4-ylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
2.1.1.45 | 2-amino-6-ethyl-5-[(4-fluorophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | - |
Escherichia coli | |
2.1.1.45 | 2-amino-6-ethyl-5-[(4-fluorophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | - |
Homo sapiens | |
2.1.1.45 | 2-amino-6-ethyl-5-[(4-fluorophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
2.1.1.45 | 2-amino-6-ethyl-5-[(4-nitrophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | - |
Escherichia coli | |
2.1.1.45 | 2-amino-6-ethyl-5-[(4-nitrophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | - |
Homo sapiens | |
2.1.1.45 | 2-amino-6-ethyl-5-[(4-nitrophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | - |
Toxoplasma gondii | |
2.1.1.45 | 4-amino-N10-methylfolic acid | - |
Escherichia coli | |
2.1.1.45 | 4-amino-N10-methylfolic acid | - |
Homo sapiens | |
2.1.1.45 | 4-amino-N10-methylfolic acid | - |
Toxoplasma gondii | |
2.1.1.45 | methotrexate | - |
Escherichia coli | |
2.1.1.45 | methotrexate | - |
Homo sapiens | |
2.1.1.45 | methotrexate | - |
Toxoplasma gondii | |
2.1.1.45 | N-[4-[(2-amino-6-ethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)thio]benzoyl]-L-glutamic acid | - |
Escherichia coli | |
2.1.1.45 | N-[4-[(2-amino-6-ethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)thio]benzoyl]-L-glutamic acid | - |
Homo sapiens | |
2.1.1.45 | N-[4-[(2-amino-6-ethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)thio]benzoyl]-L-glutamic acid | - |
Toxoplasma gondii | |
2.1.1.45 | N-[4-[(2-amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)sulfanyl]benzoyl]-L-glutamic acid | potent inhibitor of thymidylate synthase | Escherichia coli | |
2.1.1.45 | N-[4-[(2-amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)sulfanyl]benzoyl]-L-glutamic acid | potent inhibitor of thymidylate synthase | Homo sapiens | |
2.1.1.45 | N-[4-[(2-amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)sulfanyl]benzoyl]-L-glutamic acid | potent inhibitor of thymidylate synthase | Toxoplasma gondii | |
2.1.1.45 | pemetrexed | - |
Escherichia coli | |
2.1.1.45 | pemetrexed | - |
Homo sapiens | |
2.1.1.45 | pemetrexed | - |
Toxoplasma gondii | |
2.1.1.45 | piritrexim | - |
Escherichia coli | |
2.1.1.45 | piritrexim | - |
Homo sapiens | |
2.1.1.45 | piritrexim | - |
Toxoplasma gondii | |
2.1.1.45 | plevitrexed | - |
Escherichia coli | |
2.1.1.45 | plevitrexed | - |
Homo sapiens | |
2.1.1.45 | plevitrexed | - |
Toxoplasma gondii | |
2.1.1.45 | raltitrexed | - |
Escherichia coli | |
2.1.1.45 | raltitrexed | - |
Homo sapiens | |
2.1.1.45 | raltitrexed | - |
Toxoplasma gondii | |
2.1.1.45 | trimethoprim | - |
Escherichia coli | |
2.1.1.45 | trimethoprim | - |
Homo sapiens | |
2.1.1.45 | trimethoprim | - |
Toxoplasma gondii | |
2.1.1.45 | trimetrexate | - |
Escherichia coli | |
2.1.1.45 | trimetrexate | - |
Homo sapiens | |
2.1.1.45 | trimetrexate | - |
Toxoplasma gondii |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.5.1.3 | 7,8-dihydrofolate + NADPH + H+ | Escherichia coli | - |
5,6,7,8-tetrahydrofolate + NADP+ | - |
? | |
1.5.1.3 | 7,8-dihydrofolate + NADPH + H+ | Toxoplasma gondii | - |
5,6,7,8-tetrahydrofolate + NADP+ | - |
? | |
1.5.1.3 | 7,8-dihydrofolate + NADPH + H+ | Homo sapiens | - |
5,6,7,8-tetrahydrofolate + NADP+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.5.1.3 | Escherichia coli | - |
- |
- |
1.5.1.3 | Homo sapiens | P00374 | - |
- |
1.5.1.3 | Toxoplasma gondii | - |
- |
- |
2.1.1.45 | Escherichia coli | - |
- |
- |
2.1.1.45 | Homo sapiens | - |
- |
- |
2.1.1.45 | Toxoplasma gondii | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.5.1.3 | recombinant wild-type and mutant enzymes from Escherichia coli strain BL21 (DE3) | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.5.1.3 | 7,8-dihydrofolate + NADPH + H+ | - |
Escherichia coli | 5,6,7,8-tetrahydrofolate + NADP+ | - |
? | |
1.5.1.3 | 7,8-dihydrofolate + NADPH + H+ | - |
Toxoplasma gondii | 5,6,7,8-tetrahydrofolate + NADP+ | - |
? | |
1.5.1.3 | 7,8-dihydrofolate + NADPH + H+ | - |
Homo sapiens | 5,6,7,8-tetrahydrofolate + NADP+ | - |
? | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | - |
Escherichia coli | dihydrofolate + dTMP | - |
? | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | - |
Homo sapiens | dihydrofolate + dTMP | - |
? | |
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | - |
Toxoplasma gondii | dihydrofolate + dTMP | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.5.1.3 | DHFR | - |
Escherichia coli |
1.5.1.3 | DHFR | - |
Toxoplasma gondii |
1.5.1.3 | DHFR | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.5.1.3 | 37 | - |
assay at | Escherichia coli |
1.5.1.3 | 37 | - |
assay at | Toxoplasma gondii |
1.5.1.3 | 37 | - |
assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.5.1.3 | 7 | - |
assay at | Escherichia coli |
1.5.1.3 | 7 | - |
assay at | Toxoplasma gondii |
1.5.1.3 | 7 | - |
assay at | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.5.1.3 | NADPH | - |
Escherichia coli | |
1.5.1.3 | NADPH | - |
Toxoplasma gondii | |
1.5.1.3 | NADPH | - |
Homo sapiens | |
2.1.1.45 | N5,N10-methylenetetrahydrofolate | - |
Escherichia coli | |
2.1.1.45 | N5,N10-methylenetetrahydrofolate | - |
Homo sapiens | |
2.1.1.45 | N5,N10-methylenetetrahydrofolate | - |
Toxoplasma gondii |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
1.5.1.3 | 0.0000000088 | - |
pH 7.0, 37°C | Escherichia coli | methotrexate | |
1.5.1.3 | 0.00000001 | - |
pH 7.0, 37°C | Escherichia coli | trimethoprim | |
1.5.1.3 | 0.000000019 | - |
pH 7.0, 37°C | Homo sapiens | N-(4-[(2-amino-6-ethyl-4-oxo-3,4-dihydrothieno[2,3-d ]pyrimidin-5-yl)thio]benzoyl)-L-glutamic acid | |
1.5.1.3 | 0.00000002 | - |
pH 7.0, 37°C | Homo sapiens | methotrexate | |
1.5.1.3 | 0.00000002 | - |
pH 7.0, 37°C | Homo sapiens | N-(4-[(2-amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d ]pyrimidin-5-yl)thio]benzoyl)-L-glutamic acid | |
1.5.1.3 | 0.0000002 | - |
pH 7.0, 37°C | Escherichia coli | N-(4-[(2-amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d ]pyrimidin-5-yl)thio]benzoyl)-L-glutamic acid | |
1.5.1.3 | 0.00000026 | - |
pH 7.0, 37°C | Homo sapiens | 2-amino-6-ethyl-5-[(4-nitrophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | |
1.5.1.3 | 0.00000026 | - |
pH 7.0, 37°C | Homo sapiens | 2-amino-5-[(4-bromophenyl)sulfanyl]-6-ethylthieno[2,3-d ]pyrimidin-4(3H)-one | |
1.5.1.3 | 0.00000028 | - |
pH 7.0, 37°C | Homo sapiens | 2-amino-5-[(3,5-dichlorophenyl)sulfanyl]-6-ethylthieno[2,3-d ]-pyrimidin-4(3H)-one | |
1.5.1.3 | 0.00000029 | - |
pH 7.0, 37°C | Homo sapiens | 2-amino-5-[(3,4-dichlorophenyl)thio]-6-ethylthieno[2,3-d ]pyrimidin-4(3H)-one | |
1.5.1.3 | 0.0000003 | - |
pH 7.0, 37°C | Homo sapiens | 2-amino-5-[(4-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
1.5.1.3 | 0.0000003 | - |
pH 7.0, 37°C | Homo sapiens | 2-amino-5-[(3-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d ]pyrimidin-4(3H)-one | |
1.5.1.3 | 0.00000035 | - |
pH 7.0, 37°C | Homo sapiens | 2-amino-6-ethyl-5-(pyridin-4-ylsulfanyl)thieno[2,3-d ]pyrimidin-4(3H)-one | |
1.5.1.3 | 0.00000054 | - |
pH 7.0, 37°C | Homo sapiens | 2-amino-5-[(3,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d ]pyrimidin-4(3H)-one | |
1.5.1.3 | 0.0000006 | - |
pH 7.0, 37°C | Homo sapiens | 2-amino-5-[(2-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d ]pyrimidin-4(3H)-one | |
1.5.1.3 | 0.00000062 | - |
pH 7.0, 37°C | Homo sapiens | 2-amino-6-ethyl-5-[(4-fluorophenyl)sulfanyl]thieno[2,3-d ]pyrimidin-4(3H)-one | |
1.5.1.3 | 0.00000084 | - |
pH 7.0, 37°C | Homo sapiens | 2-amino-5-[(2,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d ]pyrimidin-4(3H)-one | |
1.5.1.3 | 0.000001 | - |
pH 7.0, 37°C | Escherichia coli | N-(4-[(2-amino-6-ethyl-4-oxo-3,4-dihydrothieno[2,3-d ]pyrimidin-5-yl)thio]benzoyl)-L-glutamic acid | |
1.5.1.3 | 0.0000021 | - |
pH 7.0, 37°C | Toxoplasma gondii | N-(4-[(2-amino-6-ethyl-4-oxo-3,4-dihydrothieno[2,3-d ]pyrimidin-5-yl)thio]benzoyl)-L-glutamic acid | |
1.5.1.3 | 0.0000022 | - |
pH 7.0, 37°C | Homo sapiens | 2-amino-6-ethyl-5-(2-naphthylthio)thieno[2,3-d ]pyrimidin-4(3H)-one | |
1.5.1.3 | 0.0000026 | - |
pH 7.0, 37°C | Homo sapiens | 2-amino-6-ethyl-5-(phenylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | |
1.5.1.3 | 0.0000028 | - |
pH 7.0, 37°C | Escherichia coli | 2-amino-5-[(3,5-dichlorophenyl)sulfanyl]-6-ethylthieno[2,3-d ]-pyrimidin-4(3H)-one | |
1.5.1.3 | 0.000003 | - |
pH 7.0, 37°C | Escherichia coli | 2-amino-5-[(3-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d ]pyrimidin-4(3H)-one | |
1.5.1.3 | 0.0000066 | - |
pH 7.0, 37°C | Homo sapiens | pemetrexed | |
1.5.1.3 | 0.000008 | - |
pH 7.0, 37°C | Toxoplasma gondii | N-(4-[(2-amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d ]pyrimidin-5-yl)thio]benzoyl)-L-glutamic acid | |
1.5.1.3 | 0.0000081 | - |
pH 7.0, 37°C | Toxoplasma gondii | 2-amino-5-[(3,4-dichlorophenyl)thio]-6-ethylthieno[2,3-d ]pyrimidin-4(3H)-one | |
1.5.1.3 | 0.0000084 | - |
pH 7.0, 37°C | Toxoplasma gondii | 2-amino-6-ethyl-5-(2-naphthylthio)thieno[2,3-d ]pyrimidin-4(3H)-one | |
1.5.1.3 | 0.000009 | - |
pH 7.0, 37°C | Toxoplasma gondii | 2-amino-5-[(4-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
1.5.1.3 | 0.000012 | - |
pH 7.0, 37°C | Toxoplasma gondii | 2-amino-5-[(3-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d ]pyrimidin-4(3H)-one | |
1.5.1.3 | 0.000013 | - |
pH 7.0, 37°C | Toxoplasma gondii | 2-amino-5-[(4-bromophenyl)sulfanyl]-6-ethylthieno[2,3-d ]pyrimidin-4(3H)-one | |
1.5.1.3 | 0.000014 | - |
pH 7.0, 37°C | Toxoplasma gondii | 2-amino-5-[(2,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d ]pyrimidin-4(3H)-one | |
1.5.1.3 | 0.000014 | - |
pH 7.0, 37°C | Toxoplasma gondii | 2-amino-5-[(3,5-dichlorophenyl)sulfanyl]-6-ethylthieno[2,3-d ]-pyrimidin-4(3H)-one | |
1.5.1.3 | 0.000017 | - |
pH 7.0, 37°C | Toxoplasma gondii | 2-amino-6-ethyl-5-(pyridin-4-ylsulfanyl)thieno[2,3-d ]pyrimidin-4(3H)-one | |
1.5.1.3 | 0.000022 | - |
pH 7.0, 37°C | Escherichia coli | 2-amino-5-[(3,4-dichlorophenyl)thio]-6-ethylthieno[2,3-d ]pyrimidin-4(3H)-one | |
1.5.1.3 | 0.000024 | - |
pH 7.0, 37°C | Toxoplasma gondii | 2-amino-5-[(3,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d ]pyrimidin-4(3H)-one | |
1.5.1.3 | 0.000025 | - |
pH 7.0, 37°C | Toxoplasma gondii | 2-amino-6-ethyl-5-[(4-fluorophenyl)sulfanyl]thieno[2,3-d ]pyrimidin-4(3H)-one | |
1.5.1.3 | 0.000027 | - |
pH 7.0, 37°C | Escherichia coli | 2-amino-5-[(3,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d ]pyrimidin-4(3H)-one | |
1.5.1.3 | 0.000027 | - |
pH 7.0, 37°C | Toxoplasma gondii | 2-amino-5-[(2-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d ]pyrimidin-4(3H)-one | |
1.5.1.3 | 0.000028 | - |
pH 7.0, 37°C | Escherichia coli | 2-amino-5-[(2,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d ]pyrimidin-4(3H)-one | |
1.5.1.3 | 0.000028 | - |
pH 7.0, 37°C | Escherichia coli | 2-amino-6-ethyl-5-(2-naphthylthio)thieno[2,3-d ]pyrimidin-4(3H)-one | |
1.5.1.3 | 0.000029 | - |
pH 7.0, 37°C | Escherichia coli | 2-amino-5-[(4-bromophenyl)sulfanyl]-6-ethylthieno[2,3-d ]pyrimidin-4(3H)-one | |
1.5.1.3 | 0.000031 | - |
pH 7.0, 37°C | Escherichia coli | 2-amino-6-ethyl-5-[(4-fluorophenyl)sulfanyl]thieno[2,3-d ]pyrimidin-4(3H)-one | |
1.5.1.3 | 0.000033 | - |
pH 7.0, 37°C | Toxoplasma gondii | methotrexate | |
1.5.1.3 | 0.000033 | - |
pH 7.0, 37°C | Escherichia coli | 2-amino-6-ethyl-5-(phenylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | |
1.5.1.3 | 0.000033 | - |
pH 7.0, 37°C | Toxoplasma gondii | 2-amino-6-ethyl-5-(phenylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | |
1.5.1.3 | 0.000033 | - |
pH 7.0, 37°C | Escherichia coli | 2-amino-6-ethyl-5-(pyridin-4-ylsulfanyl)thieno[2,3-d ]pyrimidin-4(3H)-one | |
1.5.1.3 | 0.000033 | - |
pH 7.0, 37°C | Escherichia coli | 2-amino-5-[(2-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d ]pyrimidin-4(3H)-one | |
1.5.1.3 | 0.000039 | - |
pH 7.0, 37°C | Escherichia coli | 2-amino-6-ethyl-5-[(4-nitrophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | |
1.5.1.3 | 0.000042 | - |
pH 7.0, 37°C | Escherichia coli | 2-amino-5-[(4-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
1.5.1.3 | 0.000087 | - |
pH 7.0, 37°C | Toxoplasma gondii | 2-amino-6-ethyl-5-[(4-nitrophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | |
1.5.1.3 | 0.00023 | - |
pH 7.0, 37°C | Escherichia coli | pemetrexed | |
1.5.1.3 | 0.00034 | - |
pH 7.0, 37°C | Homo sapiens | trimethoprim | |
1.5.1.3 | 0.00043 | - |
pH 7.0, 37°C | Toxoplasma gondii | pemetrexed | |
1.5.1.3 | 0.0068 | - |
pH 7.0, 37°C | Toxoplasma gondii | trimethoprim | |
2.1.1.45 | 0.000018 | - |
- |
Escherichia coli | N-[4-[(2-amino-6-ethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)thio]benzoyl]-L-glutamic acid | |
2.1.1.45 | 0.000019 | - |
- |
Escherichia coli | 10-propargyl-5,8-dideazafolate | |
2.1.1.45 | 0.000036 | - |
- |
Toxoplasma gondii | N-[4-[(2-amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)sulfanyl]benzoyl]-L-glutamic acid | |
2.1.1.45 | 0.00004 | - |
- |
Escherichia coli | N-[4-[(2-amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)sulfanyl]benzoyl]-L-glutamic acid | |
2.1.1.45 | 0.00004 | - |
- |
Homo sapiens | N-[4-[(2-amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)sulfanyl]benzoyl]-L-glutamic acid | |
2.1.1.45 | 0.000054 | - |
- |
Homo sapiens | N-[4-[(2-amino-6-ethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)thio]benzoyl]-L-glutamic acid | |
2.1.1.45 | 0.000085 | - |
- |
Homo sapiens | 10-propargyl-5,8-dideazafolate | |
2.1.1.45 | 0.00009 | - |
- |
Toxoplasma gondii | N-[4-[(2-amino-6-ethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)thio]benzoyl]-L-glutamic acid | |
2.1.1.45 | 0.00022 | - |
- |
Homo sapiens | 2-amino-6-ethyl-5-[(4-nitrophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | |
2.1.1.45 | 0.00023 | - |
- |
Homo sapiens | 2-amino-5-[(3,4-dichlorophenyl)thio]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
2.1.1.45 | 0.00028 | - |
- |
Homo sapiens | 2-amino-6-ethyl-5-(pyridin-4-ylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | |
2.1.1.45 | 0.00038 | - |
- |
Homo sapiens | 2-amino-5-[(3-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
2.1.1.45 | 0.00039 | - |
- |
Homo sapiens | 2-amino-5-[(4-bromophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
2.1.1.45 | 0.00043 | - |
- |
Toxoplasma gondii | 10-propargyl-5,8-dideazafolate | |
2.1.1.45 | 0.00069 | - |
- |
Homo sapiens | 2-amino-5-[(3,5-dichlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]-pyrimidin-4(3H)-one | |
2.1.1.45 | 0.00075 | - |
- |
Homo sapiens | 2-amino-5-[(4-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
2.1.1.45 | 0.001 | - |
- |
Toxoplasma gondii | 2-amino-6-ethyl-5-[(4-nitrophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | |
2.1.1.45 | 0.001 | - |
- |
Toxoplasma gondii | 2-amino-5-[(3,4-dichlorophenyl)thio]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
2.1.1.45 | 0.0011 | - |
- |
Toxoplasma gondii | 2-amino-6-ethyl-5-(2-naphthylthio)thieno[2,3-d]pyrimidin-4(3H)-one | |
2.1.1.45 | 0.0011 | - |
- |
Homo sapiens | 2-amino-5-[(2-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
2.1.1.45 | 0.0012 | - |
- |
Escherichia coli | 2-amino-5-[(3,5-dichlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]-pyrimidin-4(3H)-one | |
2.1.1.45 | 0.0012 | - |
- |
Homo sapiens | 2-amino-5-[(3,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
2.1.1.45 | 0.0013 | - |
- |
Homo sapiens | 2-amino-6-ethyl-5-[(4-fluorophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | |
2.1.1.45 | 0.0014 | - |
- |
Escherichia coli | 2-amino-6-ethyl-5-(2-naphthylthio)thieno[2,3-d]pyrimidin-4(3H)-one | |
2.1.1.45 | 0.0016 | - |
- |
Toxoplasma gondii | 2-amino-5-[(3,5-dichlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]-pyrimidin-4(3H)-one | |
2.1.1.45 | 0.0017 | - |
- |
Escherichia coli | 2-amino-6-ethyl-5-[(4-nitrophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | |
2.1.1.45 | 0.0017 | - |
- |
Toxoplasma gondii | 2-amino-6-ethyl-5-(pyridin-4-ylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | |
2.1.1.45 | 0.0018 | - |
- |
Toxoplasma gondii | 2-amino-5-[(3-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
2.1.1.45 | 0.0018 | - |
- |
Escherichia coli | 2-amino-5-[(3,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
2.1.1.45 | 0.002 | - |
- |
Escherichia coli | 2-amino-6-ethyl-5-(pyridin-4-ylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | |
2.1.1.45 | 0.002 | - |
- |
Escherichia coli | 2-amino-5-[(2-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
2.1.1.45 | 0.0022 | - |
- |
Toxoplasma gondii | 2-amino-5-[(4-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
2.1.1.45 | 0.0022 | - |
- |
Escherichia coli | 2-amino-5-[(4-bromophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
2.1.1.45 | 0.0022 | - |
- |
Toxoplasma gondii | 2-amino-5-[(4-bromophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
2.1.1.45 | 0.0023 | - |
- |
Escherichia coli | 2-amino-5-[(3,4-dichlorophenyl)thio]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
2.1.1.45 | 0.0023 | - |
- |
Homo sapiens | 2-amino-6-ethyl-5-(2-naphthylthio)thieno[2,3-d]pyrimidin-4(3H)-one | |
2.1.1.45 | 0.0023 | - |
- |
Escherichia coli | 2-amino-5-[(3-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
2.1.1.45 | 0.0023 | - |
- |
Toxoplasma gondii | 2-amino-5-[(3,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
2.1.1.45 | 0.0025 | - |
- |
Escherichia coli | 2-amino-5-[(4-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
2.1.1.45 | 0.0025 | - |
- |
Toxoplasma gondii | 2-amino-5-[(2-chlorophenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
2.1.1.45 | 0.0026 | - |
- |
Toxoplasma gondii | 2-amino-6-ethyl-5-[(4-fluorophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | |
2.1.1.45 | 0.0028 | - |
- |
Toxoplasma gondii | pemetrexed | |
2.1.1.45 | 0.0029 | - |
- |
Escherichia coli | 2-amino-6-ethyl-5-[(4-fluorophenyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one | |
2.1.1.45 | 0.0046 | - |
- |
Homo sapiens | 2-amino-5-[(2,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
2.1.1.45 | 0.0056 | - |
- |
Homo sapiens | 2-amino-6-ethyl-5-(phenylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | |
2.1.1.45 | 0.0084 | - |
- |
Toxoplasma gondii | 2-amino-6-ethyl-5-(phenylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | |
2.1.1.45 | 0.0095 | - |
- |
Homo sapiens | pemetrexed | |
2.1.1.45 | 0.023 | - |
IC50 above 0.023 mM | Escherichia coli | 2-amino-5-[(2,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
2.1.1.45 | 0.023 | - |
IC50 above 0.023 mM | Toxoplasma gondii | 2-amino-5-[(2,5-dimethoxyphenyl)sulfanyl]-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one | |
2.1.1.45 | 0.028 | - |
- |
Escherichia coli | 2-amino-6-ethyl-5-(phenylsulfanyl)thieno[2,3-d]pyrimidin-4(3H)-one | |
2.1.1.45 | 0.076 | - |
- |
Escherichia coli | pemetrexed |