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Literature summary extracted from

  • Holleboom, A.G.; Kuivenhoven, J.A.; Vergeer, M.; Hovingh, G.K.; van Miert, J.N.; Wareham, N.J.; Kastelein, J.J.; Khaw, K.T.; Boekholdt, S.M.
    Plasma levels of lecithin:cholesterol acyltransferase and risk of future coronary artery disease in apparently healthy men and women: a prospective case-control analysis nested in the EPIC-Norfolk population study (2010), J. Lipid Res., 51, 416-421.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.43 apolipoprotein A-I required as cofactor Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.43 additional information deleterious LCAT mutants show low HDL-cholesterol levels Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.43 extracellular blood plasma Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.43 phosphatidylcholine + cholesterol Homo sapiens LCAT hydrolyzes the sn-2 acyl group of phosphatidylcholine and subsequently transfers and esterifies the fatty acid to free cholesterol with apolipoprotein A-I as cofactor cholesteryl ester + lysophosphatidylcholine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.43 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.43 blood plasma LCAT levels are higher in females compared to males Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.43 phosphatidylcholine + cholesterol LCAT hydrolyzes the sn-2 acyl group of phosphatidylcholine and subsequently transfers and esterifies the fatty acid to free cholesterol with apolipoprotein A-I as cofactor Homo sapiens cholesteryl ester + lysophosphatidylcholine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.43 LCAT
-
 Homo sapiens
2.3.1.43 lecithin:cholesterol acyltransferase
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.3.1.43 malfunction a high LCAT level is associated with an increased coronary artery disease risk in women Homo sapiens
2.3.1.43 physiological function LCAT plays a role in HDL maturation Homo sapiens