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Literature summary extracted from

  • Ghosh, K.; Tyagi, N.; Kumar, P.; Singh, U.P.; Goel, N.
    Stabilization of Mn(II) and Mn(III) in mononuclear complexes derived from tridentate ligands with N(2)O donors: Synthesis, crystal structure, superoxide dismutase activity and DNA interaction studies (2009), J. Inorg. Biochem., 104, 9-18.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.15.1.1 Mn(Me-Phimp)2(ClO4) i.e. Mn(2-(1-(2-phenyl-2-(pyridine-2-yl)hydrazono)ethyl)phenol)chlorate, active as cofactor in superoxide dismutation reaction Homo sapiens
1.15.1.1 Mn(N-Phimp)2 i.e. Mn-(2-((2-phenyl-2-(pyridin-2-yl)hydrazono)methyl)naphthalen-1-ol), active as cofactor in superoxide dismutation reaction Homo sapiens
1.15.1.1 Mn(N-Phimp)2(ClO4) i.e. Mn(2-((2-phenyl-2-(pyridin-2-yl)hydrazono)methyl)naphthalen-1-ol)chlorate, active as cofactor in superoxide dismutation reaction Homo sapiens
1.15.1.1 Mn(Phimp)2 i.e. Mn(2-((2-phenyl-2-(pyridin-2-yl)hydazono)methyl)phenol), active as cofactor in superoxide dismutation reaction Homo sapiens
1.15.1.1 Mn(Phimp)2(ClO4) i.e. Mn(2-((2-phenyl-2-(pyridin-2-yl)hydazono)methyl)phenol)chlorate, active as cofactor in superoxide dismutation reaction Homo sapiens
1.15.1.1 additional information ligand complex synthesis, electrochemical properties, and structure determination, overview Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.15.1.1 Manganese a MnSOD Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.15.1.1 2 O2.- + 2 H+ Homo sapiens
-
 O2 + H2O2
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
1.15.1.1 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.15.1.1 2 O2.- + 2 H+
-
 Homo sapiens O2 + H2O2
-
 ir
1.15.1.1 2 O2.- + 2 H+ enzyme activity determination by xanthine-xanthine oxidase-nitro blue tetrazolium assay Homo sapiens O2 + H2O2
-
 ir

Synonyms

EC Number Synonyms Comment Organism
1.15.1.1 MnSOD
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.15.1.1 7.8
-
 assay at Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.15.1.1 0.00029
-
-
 Homo sapiens Mn(Phimp)2
1.15.1.1 0.00039
-
-
 Homo sapiens Mn(Phimp)2(ClO4)
1.15.1.1 0.00076
-
-
 Homo sapiens Mn(Me-Phimp)2(ClO4)
1.15.1.1 0.00112
-
-
 Homo sapiens Mn(N-Phimp)2(ClO4)