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Literature summary extracted from

  • Golczak, M.; Kiser, P.D.; Lodowski, D.T.; Maeda, A.; Palczewski, K.
    Importance of membrane structural integrity for RPE65 retinoid isomerization activity (2010), J. Biol. Chem., 285, 9667-9682.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.1.64 additional information the lipid membrane structure is critical for RPE65 enzymatic activity Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.1.1.64 hanging drop vapor diffusion method, using 100 mM MES, pH 6.0, 30% (w/v) polyethylene glycol 200, and 2 mM dithiothreitol, at 22°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.64 membrane microsome Homo sapiens 16020
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.64 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.64
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.64 retinal pigment epithelium
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.64 all-trans-retinyl ester + H2O
-
 Homo sapiens 11-cis-retinol + a fatty acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.64 Rpe65
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.1.1.64 physiological function RPE65 operates in a multiprotein complex with retinol dehydrogenase 5 and retinal G protein-coupled receptor in RPE microsomes Homo sapiens