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Literature summary extracted from

  • Fox, J.T.; Shin, W.K.; Caudill, M.A.; Stover, P.J.
    A UV-responsive internal ribosome entry site enhances serine hydroxymethyltransferase 1 expression for DNA damage repair (2009), J. Biol. Chem., 284, 31097-31108.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.2.1 cytoplasm
-
 Homo sapiens 5737
-
2.1.2.1 nucleus SHMT1 localizes to the nucleus in response to UV treatment Homo sapiens 5634
-

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.2.1 HeLa cell
-
 Homo sapiens
-
2.1.2.1 Hs 925.T cell
-
 Homo sapiens
-
2.1.2.1 MCF-7 cell
-
 Homo sapiens
-
2.1.2.1 SH-SY5Y cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.1 L-serine + tetrahydrofolate
-
 Homo sapiens glycine + 5,10-methylenetetrahydrofolate + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.2.1 serine hydroxymethyltransferase 1
-
 Homo sapiens
2.1.2.1 SHMT1
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.1.2.1 Homo sapiens a non-lethal dose of UV-C radiation (10 mJ/cm2 UV (254 nm)) increases SHMT1 internal ribosome entry site activity and protein levels up

General Information

EC Number General Information Comment Organism
2.1.2.1 physiological function the UV-induced increase in SHMT1 translation is accompanied by an increase in the small ubiquitin-like modifier-dependent nuclear localization of the de novo thymidylate biosynthesis pathway and a decrease in DNA strand breaks, suggesting that SHMT1 plays a role in DNA repair Homo sapiens