Literature summary extracted from

Chen, A.; Zhang, D.; Poulter, C.
(S)-geranylgeranylglyceryl phosphate synthase. Purification and characterization of the first pathway-specific enzyme in archaebacterial membrane lipid biosynthesis (1993), J. Biol. Chem., 268, 21701-21705.

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
2.5.1.41	0.0041	-	geranylgeranyl diphosphate	Vmax: 0.004 mmol/min/mg	Methanothermobacter thermautotrophicus
2.5.1.41	0.041	-	sn-glycerol 1-phosphate	-	Methanothermobacter thermautotrophicus

Metals/Ions

EC Number	Metals/Ions	Comment	Organism	Structure
2.5.1.41	Mg2+	required for optimal activity	Methanothermobacter thermautotrophicus

Molecular Weight [Da]

EC Number	Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
2.5.1.41	29000	-	native SDS-PAGE	Methanothermobacter thermautotrophicus

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.5.1.41	Methanothermobacter thermautotrophicus	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
2.5.1.41	using ammonium sulfate precipitation, four chromatographic steps (DE52, Q-Sepharose, phenyl-Superose, and Protein Pak)	Methanothermobacter thermautotrophicus

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.5.1.41	geranylgeranyl diphosphate + sn-glycerol 1-phosphate	-	Methanothermobacter thermautotrophicus	diphosphate + 3-O-(geranylgeranyl)glyceryl 1-phosphate	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.5.1.41	((S)-GGGP) synthase	-	Methanothermobacter thermautotrophicus
2.5.1.41	(S)-3-O-geranylgeranylglycerylphosphate	-	Methanothermobacter thermautotrophicus
2.5.1.41	GGGP synthase	-	Methanothermobacter thermautotrophicus

Temperature Optimum [°C]

EC Number	Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
2.5.1.41	60	-	assay at	Methanothermobacter thermautotrophicus

Temperature Range [°C]

EC Number	Temperature Minimum [°C]	Temperature Maximum [°C]	Comment	Organism
2.5.1.41	50	65	maximal activity	Methanothermobacter thermautotrophicus

pH Optimum

EC Number	pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
2.5.1.41	7	-	assay at	Methanothermobacter thermautotrophicus

pH Range

EC Number	pH Minimum	pH Maximum	Comment	Organism
2.5.1.41	6	7.5	-	Methanothermobacter thermautotrophicus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)