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Literature summary extracted from

  • Okajima, T.; Matsuura, A.; Matsuda, T.
    Biological functions of glycosyltransferase genes involved in O-fucose glycan synthesis (2008), J. Biochem., 144, 1-6.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.221 cell surface OFUT1 associates with Notch at the cell surface and promotes the constitutive endocytosis of Notch receptors Drosophila sp. (in: flies) 9986
-
2.4.1.221 endoplasmic reticulum OFUT1 is required for the correct folding of Notch receptors in the endoplasmic reticulum and their subsequent trafficking to the cell surface Drosophila sp. (in: flies) 5783
-
2.4.1.221 additional information adherens junction Drosophila sp. (in: flies)
-
-
2.4.1.221 plasma membrane OFUT1 promotes transcytosis of Notch from the apical plasma membrane to the adherens junctions Drosophila sp. (in: flies) 5886
-

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.221 Drosophila sp. (in: flies)
-
-
-
2.4.1.221 Mus musculus
-
-
-

Synonyms

EC Number Synonyms Comment Organism
2.4.1.221 O-fucosyltransferase 1
-
 Drosophila sp. (in: flies)
2.4.1.221 O-fucosyltransferase 1
-
 Mus musculus
2.4.1.221 OFUT1
-
 Drosophila sp. (in: flies)
2.4.1.221 Pofut1
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.4.1.221 malfunction loss of OFUT1 results in the phenotype that is characteristic of Notch loss of function. Loss of OFUT1 leads to the loss of cell surface expression and the intracellular accumulation of Notch receptors. Secretion of Notch is impaired in OFUT1-depleted S2 cells and the abnormal endoplasmic reticulum accumulation of Notch receptors is observed in Ofut1 mutant clones in Drosophila wing imaginal discs Drosophila sp. (in: flies)
2.4.1.221 malfunction loss of Pofut1 results in the phenotype that is characteristic of Notch loss of function Mus musculus
2.4.1.221 physiological function is essential for Notch signalling Mus musculus
2.4.1.221 physiological function is essential for Notch signalling. Ability of OFUT1 to promote Notch secretion does not depend on its enzyme activity, suggesting the chaperon-like role of OFUT1 Drosophila sp. (in: flies)