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Literature summary extracted from

  • McTamney, P.M.; Rokita, S.E.
    A mammalian reductive deiodinase has broad power to dehalogenate chlorinated and brominated substrates (2009), J. Am. Chem. Soc., 131, 14212-14213.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.21.1.1
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.21.1.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.1.1 3-bromo-L-tyrosine + NADPH + H+
-
 Homo sapiens L-tyrosine + NADP+ + Br-
-
 ?
1.21.1.1 3-chloro-L-tyrosine + NADPH + H+
-
 Homo sapiens L-tyrosine + NADP+ + Cl-
-
 ?
1.21.1.1 3-iodo-L-tyrosine + NADPH + H+
-
 Homo sapiens L-tyrosine + NADP+ + I-
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.21.1.1 IYD
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.21.1.1 flavin presence of a neutral flavin radical during the reaction. Radical is stable and persists at 4°C under aerobic conditions for many days Homo sapiens