Literature summary extracted from

Comini, M.A.; Dirdjaja, N.; Kaschel, M.; Krauth-Siegel, R.L.
Preparative enzymatic synthesis of trypanothione and trypanothione analogues (2009), Int. J. Parasitol., 39, 1059-1062.

Application

EC Number	Application	Comment	Organism
6.3.1.9	synthesis	production of trypanothione and trypanothione disulfide in >200 mg quantities by mutant C59A lacking the amidase activity. The protocol also allows the synthesis of related glutathione conjugates	Crithidia fasciculata

Protein Variants

EC Number	Protein Variants	Comment	Organism
6.3.1.9	C59A	mutant lacks the amidase activity, while the synthetase activity is similar to wild-type. Constructed for the production of trypanothione and trypanothione disulfide in >200 mg quantities. The protocol also allows the synthesis of related glutathione conjugates	Crithidia fasciculata

Organism

EC Number	Organism	UniProt	Comment	Textmining
6.3.1.9	Crithidia fasciculata	-	-	-

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Release 2023.1 (January 2023)