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Literature summary extracted from

  • Zhu, H.; Glasgow, W.; George, M.D.; Chrysovergis, K.; Olden, K.; Roberts, J.D.; Eling, T.
    15-lipoxygenase-1 activates tumor suppressor p53 independent of enzymatic activity (2008), Int. J. Cancer, 123, 2741-2749.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.13.11.33 pcDNA3.1(1) vector carrying native or mutant 15-LOX-1 expressed in HCT-116 cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.13.11.33 H361L is devoid of enzymatic activity, can induce phosphorylation of p53 as the wild-type Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.33 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.33 A-549 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.33 arachidonate + O2
-
 Homo sapiens (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.33 15-lipoxygenase-1
-
 Homo sapiens
1.13.11.33 15-LOX-1
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
1.13.11.33 Homo sapiens interleukin-4 increases the expression of 15-LOX-1 and of downstream targets of p53 up

General Information

EC Number General Information Comment Organism
1.13.11.33 physiological function 15-LOX-1 induces phosphorylation of tumor suppressor p53 independent of enzymatic activity. HCT-116 cells transiently transfected with either native or mutant 15-LOX-1 show an increase in p53 phosphorylation and an increase in the expression of downstream genes. 15-LOX-1 interacts with, and binds to, DNA-dependent protein kinase, which causes an approximate 3fold enhancement in kinase activity, resulting in increased p53 phosphorylation at Ser15 Homo sapiens