EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.13.11.31 | PD146176 | selective inhibitor of 12/15-LOX, macrophages treated with PD146176 elaborate reduced levels of interleukin-12 in response to Toxoplasma gondii antigen | Mus musculus | |
1.13.11.33 | PD146176 | selective inhibitor of 12/15-LOX, macrophages treated with PD146176 elaborate reduced levels of interleukin-12 in response to Toxoplasma gondii antigen | Mus musculus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.13.11.31 | Mus musculus | - |
C57BL/6 mice | - |
1.13.11.31 | Mus musculus C57BL/6 | - |
C57BL/6 mice | - |
1.13.11.33 | Mus musculus | - |
C57BL/6 mice | - |
1.13.11.33 | Mus musculus C57BL/6 | - |
C57BL/6 mice | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.13.11.31 | brain | 12/15-LOX is selectively enhanced in the periphery, 12/15-LOX-expressing myeloid cells are enriched in the brain during chronic toxoplasmosis | Mus musculus | - |
1.13.11.31 | macrophage | 12/15-LOX is a macrophage-selective regulator of interleukin-12 production | Mus musculus | - |
1.13.11.33 | brain | 12/15-LOX is selectively enhanced in the periphery, 12/15-LOX-expressing myeloid cells are enriched in the brain during chronic toxoplasmosis | Mus musculus | - |
1.13.11.33 | macrophage | 12/15-LOX is a macrophage-selective regulator of interleukin-12 production | Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.13.11.31 | arachidonate + O2 | - |
Mus musculus | (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate | - |
? | |
1.13.11.31 | arachidonate + O2 | - |
Mus musculus C57BL/6 | (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate | - |
? | |
1.13.11.33 | arachidonate + O2 | - |
Mus musculus | (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate | - |
? | |
1.13.11.33 | arachidonate + O2 | - |
Mus musculus C57BL/6 | (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.13.11.31 | 12/15-lipoxygenase | - |
Mus musculus |
1.13.11.31 | 12/15-LOX | - |
Mus musculus |
1.13.11.33 | 12/15-lipoxygenase | - |
Mus musculus |
1.13.11.33 | 12/15-LOX | - |
Mus musculus |
EC Number | Organism | Comment | Expression |
---|---|---|---|
1.13.11.31 | Mus musculus | 12/15-LOX activity is enhanced during chronic, but not acute, toxoplasmosis | up |
1.13.11.33 | Mus musculus | 12/15-LOX activity is enhanced during chronic, but not acute, toxoplasmosis | up |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.13.11.31 | physiological function | 12/15-LOX is a critical mediator of the chronic type 1 inflammatory response. Evolution of the immune response to Toxoplasma gondii is accompanied by an increasing requirement for 12/15-LOX mediated signaling. Although 12/15-LOX deficient mice are resistant to acute Toxoplasma gondii infection, 80% of 12/15-LOX-deficient mice die during chronic toxoplasmosis, compared to no deaths in wild-type controls. The enhanced susceptibility of 12/15-LOX-deficient mice to chronic toxoplasmosis is associated with reduced production of IL-12 and gamma interferon (IFN-gamma) that is not evident during acute infection. Ex vivo IFN-gamma production by 12/15-LOX-deficient splenocytes can be rescued by the addition of recombinant IL-12. 12/15-LOX does not play a role in macrophage killing of Toxoplasma gondii in vitro | Mus musculus |
1.13.11.33 | physiological function | 12/15-LOX is a critical mediator of the chronic type 1 inflammatory response. Evolution of the immune response to Toxoplasma gondii is accompanied by an increasing requirement for 12/15-LOX mediated signaling. Although 12/15-LOX deficient mice are resistant to acute Toxoplasma gondii infection, 80% of 12/15-LOX-deficient mice die during chronic toxoplasmosis, compared to no deaths in wild-type controls. The enhanced susceptibility of 12/15-LOX-deficient mice to chronic toxoplasmosis is associated with reduced production of IL-12 and gamma interferon (IFN-gamma) that is not evident during acute infection. Ex vivo IFN-gamma production by 12/15-LOX-deficient splenocytes can be rescued by the addition of recombinant IL-12. 12/15-LOX does not play a role in macrophage killing of Toxoplasma gondii in vitro | Mus musculus |