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Literature summary extracted from

  • Fukuoh, A.; Ohgaki, K.; Hatae, H.; Kuraoka, I.; Aoki, Y.; Uchiumi, T.; Jacobs, H.T.; Kang, D.
    DNA conformation-dependent activities of human mitochondrial RNA polymerase (2009), Genes Cells, 14, 1029-1042.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.7.6 TFB2M the requirement for TFB2M in transcription of dsDNA is that it can stabilize an incompletely single-stranded template established by negative supercoiling Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.6 TFAM DNA packaging by TFAM makes the DNA more resistant to unwinding Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.6 mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.6 nucleoside triphosphate + RNAn Homo sapiens
-
 diphosphate + RNAn+1
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.6 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.6 additional information negative DNA supercoiling favors the induction of unpaired regions at some sequence motifs on dsDNA, substrate specificity and structural effects on activity, overview Homo sapiens ?
-
 ?
2.7.7.6 nucleoside triphosphate + RNAn
-
 Homo sapiens diphosphate + RNAn+1
-
 ?
2.7.7.6 nucleoside triphosphate + RNAn DNA supercoiling-dependent and LSP-dependent RNA synthesis, three templates are used for in vitro RNA synthesis: the run-off template contains the light strand promoter, conserved sequence blocks, and heavy-strand origin. Promoter-independent RNA synthesis is dependent on DNA supercoiling and on TFB2M Homo sapiens diphosphate + RNAn+1
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.6 mitochondrial RNA polymerase
-
 Homo sapiens
2.7.7.6 POLRMT
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.7.6 37
-
 assay at Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.7.6 physiological function POLRMT is a key molecule of the core complex of the mitochondrial transcription machinery which assembles at promoter sequences on both strands of mtDNA, termed the L-strand promoter and H-strand promoter Homo sapiens