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Literature summary extracted from

  • Rahman, F.B.; Yamauchi, K.
    Characterization of iodothyronine sulfotransferase activity in the cytosol of Rana catesbeiana tadpole tissues (2010), Gen. Comp. Endocrinol., 166, 396-403.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.2.2 2,6-dibromophenol
-
 Lithobates catesbeianus
2.8.2.2 2,6-Dichloro-4-nitrophenol
-
 Lithobates catesbeianus
2.8.2.2 2,6-dichlorophenol
-
 Lithobates catesbeianus
2.8.2.2 ioxynil
-
 Lithobates catesbeianus
2.8.2.2 additional information nonylphenol and bisphenol A (non-halogenated phenol and phenolic compounds) have little effect on T3 sulfation (inhibition at 0.001 mM = 4% and 9%, respectively) Lithobates catesbeianus
2.8.2.2 pentabromophenol
-
 Lithobates catesbeianus
2.8.2.2 Pentachlorophenol most potent competitor Lithobates catesbeianus
2.8.2.2 tetrabromobisphenol A 52% inhibition at 0.001 mM Lithobates catesbeianus
2.8.2.2 tetrachlorobisphenol A 45% inhibition at 0.001 mM Lithobates catesbeianus
2.8.2.2 tribromophenol
-
 Lithobates catesbeianus
2.8.2.2 trichlorophenol
-
 Lithobates catesbeianus
2.8.2.2 triiodophenol
-
 Lithobates catesbeianus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.8.2.2 0.00022
-
 3,3',5-triiodothyronine in 0.1 M sodium phosphate, pH 7.2, and 2 mM EDTA for 30 min at 16°C Lithobates catesbeianus
2.8.2.2 0.00109
-
 3'-phosphoadenylyl sulfate in 0.1 M sodium phosphate, pH 7.2, and 2 mM EDTA for 30 min at 16°C Lithobates catesbeianus
2.8.2.2 0.00477
-
 3,3',5-Triiodothyroacetic acid in 0.1 M sodium phosphate, pH 7.2, and 2 mM EDTA for 30 min at 16°C Lithobates catesbeianus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.2.2 cytosol
-
 Lithobates catesbeianus 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.2 3'-phosphoadenylyl sulfate + 3,3',5'-triiodothyronine Lithobates catesbeianus best substrate adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.2 3'-phosphoadenylyl sulfate + 3,3',5,5'-tetraiodothyroacetic acid Lithobates catesbeianus
-
 adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.2 3'-phosphoadenylyl sulfate + 3,3',5-triiodothyroacetic acid Lithobates catesbeianus
-
 adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.2 3'-phosphoadenylyl sulfate + 3,3',5-triiodothyronine Lithobates catesbeianus
-
 adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.2 3'-phosphoadenylyl sulfate + 3,5-diiodothyronine Lithobates catesbeianus
-
 adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.2 3'-phosphoadenylyl sulfate + 3-iodothyronine Lithobates catesbeianus
-
 adenosine 3',5'-bisphosphate + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.2 Lithobates catesbeianus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.2 liver
-
 Lithobates catesbeianus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.2 3'-phosphoadenylyl sulfate + 3,3',5'-triiodothyronine best substrate Lithobates catesbeianus adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.2 3'-phosphoadenylyl sulfate + 3,3',5,5'-tetraiodothyroacetic acid
-
 Lithobates catesbeianus adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.2 3'-phosphoadenylyl sulfate + 3,3',5-triiodothyroacetic acid
-
 Lithobates catesbeianus adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.2 3'-phosphoadenylyl sulfate + 3,3',5-triiodothyronine
-
 Lithobates catesbeianus adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.2 3'-phosphoadenylyl sulfate + 3,5-diiodothyronine
-
 Lithobates catesbeianus adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.2 3'-phosphoadenylyl sulfate + 3-iodothyronine
-
 Lithobates catesbeianus adenosine 3',5'-bisphosphate + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.2 iodothyronine sulfotransferase
-
 Lithobates catesbeianus
2.8.2.2 SULT
-
 Lithobates catesbeianus
2.8.2.2 thyroid hormone sulfotransferase
-
 Lithobates catesbeianus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.8.2.2 0.00015
-
 in 0.1 M sodium phosphate, pH 7.2, and 2 mM EDTA for 30 min at 16°C Lithobates catesbeianus Pentachlorophenol
2.8.2.2 0.00016
-
 in 0.1 M sodium phosphate, pH 7.2, and 2 mM EDTA for 30 min at 16°C Lithobates catesbeianus pentabromophenol
2.8.2.2 0.00021
-
 in 0.1 M sodium phosphate, pH 7.2, and 2 mM EDTA for 30 min at 16°C Lithobates catesbeianus triiodophenol
2.8.2.2 0.00036
-
 in 0.1 M sodium phosphate, pH 7.2, and 2 mM EDTA for 30 min at 16°C Lithobates catesbeianus 2,6-dichlorophenol
2.8.2.2 0.00037
-
 in 0.1 M sodium phosphate, pH 7.2, and 2 mM EDTA for 30 min at 16°C Lithobates catesbeianus trichlorophenol
2.8.2.2 0.00049
-
 in 0.1 M sodium phosphate, pH 7.2, and 2 mM EDTA for 30 min at 16°C Lithobates catesbeianus 2,6-Dichloro-4-nitrophenol
2.8.2.2 0.00055
-
 in 0.1 M sodium phosphate, pH 7.2, and 2 mM EDTA for 30 min at 16°C Lithobates catesbeianus 2,6-dibromophenol
2.8.2.2 0.0008
-
 in 0.1 M sodium phosphate, pH 7.2, and 2 mM EDTA for 30 min at 16°C Lithobates catesbeianus tribromophenol
2.8.2.2 0.00097
-
 in 0.1 M sodium phosphate, pH 7.2, and 2 mM EDTA for 30 min at 16°C Lithobates catesbeianus ioxynil
2.8.2.2 0.00097
-
 in 0.1 M sodium phosphate, pH 7.2, and 2 mM EDTA for 30 min at 16°C Lithobates catesbeianus tetrabromobisphenol A

Expression

EC Number Organism Comment Expression
2.8.2.2 Lithobates catesbeianus iodothyronine sulfating activity in the liver cytosol is increased in tadpoles at premetamorphic (stages IX-X) and metamorphic climax (stage XX) stages, and in adult frogs up