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Literature summary extracted from

  • Pavlovic, N.; Orem, W.; Tatu, C.; Lerch, H.; Bunnell, J.; Feder, G.; Kostic, E.; Ordodi, V.
    The role of lecithin cholesterol acyltransferase and organic substances from coal in the etiology of Balkan endemic nephropathy: A new hypothesis (2008), Food Chem. Toxicol., 46, 949-954.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.43 additional information water samples from Balkan endemic nephropathy, BEN, villages from Serbia and Romania show higher LCAT inhibiting activity compared to deionised water and non-endemic water. Inhibitory effect of the organic compounds found in endemic water supplies can cause secondary LCAT deficiency and provide an ethiopathogenic basis for the development of BEN in the susceptible population, overview Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.43 extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.43 phosphatidylcholine + cholesterol Homo sapiens
-
 cholesteryl ester + lysophosphatidylcholine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.43 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.43 blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.43 phosphatidylcholine + cholesterol
-
 Homo sapiens cholesteryl ester + lysophosphatidylcholine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.43 LCAT
-
 Homo sapiens
2.3.1.43 lecithin cholesterol acyltransferase
-
 Homo sapiens
2.3.1.43 plasma lecithin-cholesterol acyltransferase
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.3.1.43 malfunction LCAT inhibition leads to the Balkan endemic nephropathy, BEN, chronic, slowly progressive renal disease, overview. Familial renal disease can develop secondary LCAT deficiency and associated lipid abnormalities Homo sapiens