EC Number | Cloned (Comment) | Organism |
---|---|---|
2.3.1.21 | expressed in Pichia pastoris | Homo sapiens |
2.3.1.21 | expressed in Pichia pastoris | Sus scrofa |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.3.1.21 | D17E | pig protein: Glu in this position | Homo sapiens |
2.3.1.21 | E17D | human protein: Asp in this position | Sus scrofa |
2.3.1.21 | additional information | deletion of residues 1-18, and deletion of residues 1-28, human-pig chimeras | Sus scrofa |
2.3.1.21 | additional information | pig-human chimeras | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.21 | malonyl-CoA | - |
Homo sapiens | |
2.3.1.21 | malonyl-CoA | - |
Sus scrofa |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.3.1.21 | 0.1976 | - |
L-carnitine | wild-type protein, mitochondrial preparation | Sus scrofa | |
2.3.1.21 | 0.6059 | - |
L-carnitine | E17D mutant protein, mitochondrial preparation | Sus scrofa | |
2.3.1.21 | 0.683 | - |
L-carnitine | wild-type protein, mitochondrial preparation | Homo sapiens | |
2.3.1.21 | 0.7695 | - |
L-carnitine | D17E mutant protein, mitochondrial preparation | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.21 | Homo sapiens | - |
- |
- |
2.3.1.21 | Sus scrofa | - |
- |
- |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.3.1.21 | 0.00279 | - |
wild-type protein, mitochondrial preparation | Sus scrofa |
2.3.1.21 | 0.00416 | - |
chimeric protein: residues 1-128 of human enzyme recombined with pig enzyme, mitochondrial preparation | Sus scrofa |
2.3.1.21 | 0.00443 | - |
wild-type protein, mitochondrial preparation | Homo sapiens |
2.3.1.21 | 0.00449 | - |
chimeric protein: residues 1-50 of human enzyme recombined with pig enzyme, mitochondrial preparation | Sus scrofa |
2.3.1.21 | 0.00942 | - |
protein with deletion of residue 1-28, mitochondrial preparation | Sus scrofa |
2.3.1.21 | 0.00943 | - |
chimeric protein: residues 1-50 of pig enzyme recombined with human enzyme, mitochondrial preparation | Homo sapiens |
2.3.1.21 | 0.01059 | - |
chimeric protein: residues 1-128 of pig enzyme recombined with human enzyme, mitochondrial preparation | Homo sapiens |
2.3.1.21 | 0.01528 | - |
protein with deletion of residue 1-18, mitochondrial preparation | Sus scrofa |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.21 | L-carnitine + palmitoyl-CoA | - |
Homo sapiens | L-palmitoylcarnitine + CoA | - |
? | |
2.3.1.21 | L-carnitine + palmitoyl-CoA | - |
Sus scrofa | L-palmitoylcarnitine + CoA | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.21 | carnitine palmitoyltransferase 1B | - |
Homo sapiens |
2.3.1.21 | carnitine palmitoyltransferase 1B | - |
Sus scrofa |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.3.1.21 | 0.000096 | - |
wild-type protein, 1 mM carnitine, mitochondrial preparation | Homo sapiens | malonyl-CoA | |
2.3.1.21 | 0.000117 | - |
wild-type protein, 0.683 mM carnitine, mitochondrial preparation | Homo sapiens | malonyl-CoA | |
2.3.1.21 | 0.00019 | - |
chimeric protein: residues 1-50 of pig enzyme recombined with human enzyme, mitochondrial preparation | Homo sapiens | malonyl-CoA | |
2.3.1.21 | 0.000246 | - |
D17E mutant protein, 0.770 mM carnitine, mitochondrial preparation | Homo sapiens | malonyl-CoA | |
2.3.1.21 | 0.000279 | - |
D17E mutant protein, 1 mM carnitine, mitochondrial preparation | Homo sapiens | malonyl-CoA | |
2.3.1.21 | 0.000284 | - |
E17D mutant protein, 0.606 mM carnitine, mitochondrial preparation | Sus scrofa | malonyl-CoA | |
2.3.1.21 | 0.000297 | - |
E17D mutant protein, 1 mM carnitine, mitochondrial preparation | Sus scrofa | malonyl-CoA | |
2.3.1.21 | 0.000325 | - |
chimeric protein: residues 1-128 of pig enzyme recombined with human enzyme, mitochondrial preparation | Homo sapiens | malonyl-CoA | |
2.3.1.21 | 0.000359 | - |
chimeric protein: residues 1-128 of human enzyme recombined with pig enzyme, mitochondrial preparation | Sus scrofa | malonyl-CoA | |
2.3.1.21 | 0.000457 | - |
chimeric protein: residues 1-50 of human enzyme recombined with pig enzyme, mitochondrial preparation | Sus scrofa | malonyl-CoA | |
2.3.1.21 | 0.00055 | - |
wild-type protein, 0.198 mM carnitine, mitochondrial preparation | Sus scrofa | malonyl-CoA | |
2.3.1.21 | 0.000804 | - |
wild-type protein, 1 mM carnitine, mitochondrial preparation | Sus scrofa | malonyl-CoA | |
2.3.1.21 | 0.03556 | - |
protein with deletion of residue 1-18, mitochondrial preparation | Sus scrofa | malonyl-CoA | |
2.3.1.21 | 0.03919 | - |
protein with deletion of residue 1-28, mitochondrial preparation | Sus scrofa | malonyl-CoA |