Literature summary extracted from

Tuckey, R.C.; Li, W.; Zjawiony, J.K.; Zmijewski, M.A.; Nguyen, M.N.; Sweatman, T.; Miller, D.; Slominski, A.
Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc (2008), FEBS J., 275, 2585-2596.

Application

EC Number	Application	Comment	Organism
1.14.15.6	drug development	the vitamin D3 derivatives produced by the action of P450scc are good candidates for use in the therapy of hyperproliferative disorders	Bos taurus

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
1.14.15.6	mitochondrion	-	Bos taurus	5739	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.14.15.6	Bos taurus	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
1.14.15.6	-	Bos taurus

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.14.15.6	adrenal cortex	-	Bos taurus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.14.15.6	20,23-dihydroxyvitamin D3 + reduced adrenodoxin + O2	-	Bos taurus	17alpha,20,23-trihydroxyvitamin D3 + oxidized adrenodoxin + H2O	-	?
1.14.15.6	20-hydroxyvitamin D3 + reduced adrenodoxin + O2	-	Bos taurus	20,23-dihydroxyvitamin D3 + 17alpha,20,23-trihydroxyvitamin D3 + oxidized adrenodoxin + H2O	-	?
1.14.15.6	vitamin D3 + reduced adrenodoxin + O2	-	Bos taurus	20-hydroxyvitamin D3 + oxidized adrenodoxin + H2O	when incubated in 0.45% cyclodextrin, 20-hydroxyvitamin D3 is the major product of vitamin D3 metabolism by P450scc. The second major product is 20,23-dihydroxyvitamin D3. Major products dissociate from the P450scc active site and accumulate at a concentration well above the P450scc concentration	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.14.15.6	CYP11A1	-	Bos taurus
1.14.15.6	cytochrome P450scc	-	Bos taurus

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.14.15.6	adrenodoxin	-	Bos taurus

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Release 2023.1 (January 2023)