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Literature summary extracted from

  • Gnidehou, S.; Caillou, B.; Talbot, M.; Ohayon, R.; Kaniewski, J.; Noel-Hudson, M.S.; Morand, S.; Agnangji, D.; Sezan, A.; Courtin, F.; Virion, A.; Dupuy, C.
    Iodotyrosine dehalogenase 1 (DEHAL1) is a transmembrane protein involved in the recycling of iodide close to the thyroglobulin iodination site (2004), FASEB J., 18, 1574-1576.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.21.1.1 transfection of HEK-293 cells results in active protein, but not of CHO cells Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.21.1.1 membrane transmembrane protein, partly exposed to cell surface, protein accumulates at the apical pole of thyrocytes Sus scrofa 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.21.1.1 33000
-
 x * 33000, SDS-PAGE and calculated Sus scrofa
1.21.1.1 33000
-
 x * 33000, SDS-PAGE and calculated Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.21.1.1 Homo sapiens Q6PHW0
-
-
1.21.1.1 Sus scrofa Q6TA49
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.21.1.1 proteolytic modification putative signal peptide with a possible cleavage site between Ala23 and Asp24 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.21.1.1 thyroid
-
 Sus scrofa
-
1.21.1.1 thyroid
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.1.1 3,5-diiodo-L-tyrosine + NADPH + H+ substrate 3-iodo-L-tyrosine is preferred over 3,5-diiodotyrosine Sus scrofa 3-iodo-L-tyrosine + NADP+ + I-
-
 ?
1.21.1.1 3-iodo-L-tyrosine + NADPH + H+
-
 Sus scrofa L-tyrosine + NADP+ + I-
-
 ?

Subunits

EC Number Subunits Comment Organism
1.21.1.1 ? x * 33000, SDS-PAGE and calculated Sus scrofa
1.21.1.1 ? x * 33000, SDS-PAGE and calculated Homo sapiens

Expression

EC Number Organism Comment Expression
1.21.1.1 Sus scrofa DEHAL12 is upregulated by cAMP up