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Literature summary extracted from

  • Chaudhry, U.; Zhuang, H.; Dore, S.
    Microsomal prostaglandin E synthase-2: cellular distribution and expression in Alzheimers disease (2010), Exp. Neurol., 223, 359-365.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.99.3 Prostaglandin H2 Homo sapiens
-
 Prostaglandin E2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.3 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.99.3 brain in brain mPGES-2 is detected in neurons, activated microglia, and endothelium, but not in resting microglia, astrocytes, or smooth muscle cells Homo sapiens
-
5.3.99.3 microglia mPGES-2 colocalizedswith microglia in activated (amoeboid-shaped) cells Homo sapiens
-
5.3.99.3 middle frontal gyrus
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.3 Prostaglandin H2
-
 Homo sapiens Prostaglandin E2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.3.99.3 microsomal prostaglandin E synthase-2
-
 Homo sapiens
5.3.99.3 mPGES-2
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
5.3.99.3 Homo sapiens mPGES-2 immunoreactivity is particularly elevated in the pyramidal neurons of brains from three of five sporadic and four of five familial Alzheimer's disease patients compared with four of five age-matched control brains that showed minimal immunoreactivity up