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Literature summary extracted from

  • Lv, X.; Wan, J.; Yang, J.; Cheng, H.; Li, Y.; Ao, Y.; Peng, R.
    Cytochrome P450 omega-hydroxylase inhibition reduces cardiomyocyte apoptosis via activation of ERK1/2 signaling in rat myocardial ischemia-reperfusion (2008), Eur. J. Pharmacol., 596, 118-126.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.15.3 17-octadecynoic acid irreversible CYP omega-hydroxylase inhibitor, significantly inhibits myocardial apoptosis Rattus norvegicus
1.14.15.3 N-hydroxy-N'-(4-n-butyl-2-methylphenyl)formamidine HET0016, a potent and selective inhibitor of CYP omega-hydroxylase, significantly inhibits myocardial apoptosis. Pretreatment with PD98059, the inhibitor of ERK1/2, but not SB203580 or SP600125, almost completely blocks the effect exerted by HET0016. Exogenous 20-hydroxyeicosatetraenoic acid administration exerts opposite effects Rattus norvegicus
1.14.15.3 N-methylsulfonyl-12, 12-dibromododec-11-enamide a selective CYP omega-hydroxylase inhibitor, significantly inhibits myocardial apoptosis Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.14.15.3 Rattus norvegicus
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adult male Wistar rats
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Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.15.3 arachidonic acid + NAD(P)H + H+ + O2
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Rattus norvegicus (5Z,8Z,11Z,14Z)-20-hydroxyeicosa-5,8,11,14-tetraenoic acid + NAD(P)+ + H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.15.3 CYP omega hydroxylase
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Rattus norvegicus
1.14.15.3 cytochrome P450 omega hydroxylase
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Rattus norvegicus

General Information

EC Number General Information Comment Organism
1.14.15.3 physiological function CYP omega-hydroxylase inhibition exerts significant anti-apoptosis effects, at least in part, by activation of ERK1/2 in ischemia/reperfusion heart. Inhibition reduces the infarct size of heart, decreases DNA fragmentation, reduces TUNEL-positive cells, attenuates caspase-3 activation, and modulates genes associated with apoptosis in rats rendered ischemia followed by reperfusion Rattus norvegicus