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Literature summary extracted from

  • Chai, X.; Zhang, J.; Hu, H.; Yu, S.; Sun, Q.; Dan, Z.; Jiang, Y.; Wu, Q.
    Design, synthesis, and biological evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase (2009), Eur. J. Med. Chem., 44, 1913-1920.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2,4-dichlorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Candida parapsilosis
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2,4-dichlorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Candida tropicalis
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2,4-dichlorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Pichia kudriavzevii
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2,4-dichlorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Trichophyton rubrum
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-bromobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Candida albicans
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-bromobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Candida parapsilosis
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-bromobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Candida tropicalis
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-bromobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Cryptococcus neoformans
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-bromobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Nannizzia gypsea
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-bromobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Pichia kudriavzevii
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-bromobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Trichophyton rubrum
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-chlorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Candida albicans
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-chlorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Candida parapsilosis
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-chlorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Candida tropicalis
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-chlorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Cryptococcus neoformans
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-chlorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Nannizzia gypsea
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-chlorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Pichia kudriavzevii
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-chlorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Trichophyton rubrum
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-fluorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Candida albicans
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-fluorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Candida parapsilosis
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-fluorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Candida tropicalis
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-fluorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Cryptococcus neoformans
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-fluorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Nannizzia gypsea
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-fluorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Pichia kudriavzevii
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-fluorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Trichophyton rubrum
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-methylbenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Candida albicans
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-methylbenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Candida parapsilosis
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-methylbenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Candida tropicalis
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-methylbenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Cryptococcus neoformans
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-methylbenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Nannizzia gypsea
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-methylbenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Pichia kudriavzevii
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-methylbenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Trichophyton rubrum
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(3-chlorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Candida albicans
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(3-chlorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Candida parapsilosis
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(3-chlorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Candida tropicalis
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(3-chlorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Cryptococcus neoformans
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(3-chlorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Nannizzia gypsea
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(3-chlorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Pichia kudriavzevii
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(3-chlorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Trichophyton rubrum
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(3-fluorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Candida albicans
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(3-fluorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Candida parapsilosis
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(3-fluorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Candida tropicalis
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(3-fluorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Cryptococcus neoformans
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(3-fluorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Nannizzia gypsea
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(3-fluorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Pichia kudriavzevii
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(3-fluorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Trichophyton rubrum
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-bromobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Candida albicans
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-bromobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Candida parapsilosis
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-bromobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Candida tropicalis
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-bromobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Cryptococcus neoformans
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-bromobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Nannizzia gypsea
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-bromobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Pichia kudriavzevii
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-bromobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Trichophyton rubrum
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-chlorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Candida albicans
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-chlorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Candida parapsilosis
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-chlorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Candida tropicalis
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-chlorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Cryptococcus neoformans
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-chlorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Nannizzia gypsea
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-chlorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Pichia kudriavzevii
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-chlorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Trichophyton rubrum
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-ethylbenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Candida albicans
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-ethylbenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Candida tropicalis
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-ethylbenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Cryptococcus neoformans
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-ethylbenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Nannizzia gypsea
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-ethylbenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Pichia kudriavzevii
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-ethylbenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Trichophyton rubrum
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-fluorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Candida albicans
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-fluorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Candida parapsilosis
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-fluorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Candida tropicalis
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-fluorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Cryptococcus neoformans
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-fluorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Nannizzia gypsea
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-fluorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Pichia kudriavzevii
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-fluorobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Trichophyton rubrum
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-methylbenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Candida albicans
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-methylbenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Candida parapsilosis
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-methylbenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Candida tropicalis
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-methylbenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Cryptococcus neoformans
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-methylbenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Nannizzia gypsea
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-methylbenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Pichia kudriavzevii
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-methylbenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Trichophyton rubrum
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-nitrobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Candida albicans
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-nitrobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Candida parapsilosis
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-nitrobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Candida tropicalis
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-nitrobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Cryptococcus neoformans
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-nitrobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Nannizzia gypsea
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-nitrobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Pichia kudriavzevii
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-nitrobenzyl)-amino]-2-propanol exhibits higher activity than fluconazole Trichophyton rubrum
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-benzyl-amino]-2-propanol exhibits higher activity than fluconazole Candida albicans
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-benzyl-amino]-2-propanol exhibits higher activity than fluconazole Candida parapsilosis
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-benzyl-amino]-2-propanol exhibits higher activity than fluconazole Candida tropicalis
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-benzyl-amino]-2-propanol exhibits higher activity than fluconazole Cryptococcus neoformans
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-benzyl-amino]-2-propanol exhibits higher activity than fluconazole Nannizzia gypsea
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-benzyl-amino]-2-propanol exhibits higher activity than fluconazole Pichia kudriavzevii
1.14.14.154 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-benzyl-amino]-2-propanol exhibits higher activity than fluconazole Trichophyton rubrum
1.14.14.154 3-nitrophenyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-amino)-methyl)-benzoate exhibits higher activity than fluconazole Candida albicans
1.14.14.154 3-nitrophenyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-amino)-methyl)-benzoate
-
 Candida tropicalis
1.14.14.154 4-(propoxycarbonyl)-phenyl-[4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]amino)methyl)]benzoate exhibits higher activity than fluconazole Candida parapsilosis
1.14.14.154 4-(propoxycarbonyl)-phenyl-[4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]amino)methyl)]benzoate
-
 Candida tropicalis
1.14.14.154 4-chlorophenyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-amino)-methyl)-benzoate exhibits activity than fluconazole Nannizzia gypsea
1.14.14.154 4-nitrophenyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-amino)-methyl)-benzoate exhibits higher activity than fluconazole Candida albicans
1.14.14.154 4-nitrophenyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-amino)-methyl)-benzoate exhibits activity than fluconazole Nannizzia gypsea
1.14.14.154 4-nitrophenyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-amino)-methyl)-benzoate exhibits higher activity than fluconazole Pichia kudriavzevii
1.14.14.154 Amphotericin B
-
 Candida albicans
1.14.14.154 Amphotericin B
-
 Candida parapsilosis
1.14.14.154 Amphotericin B
-
 Candida tropicalis
1.14.14.154 Amphotericin B
-
 Cryptococcus neoformans
1.14.14.154 Amphotericin B
-
 Nannizzia gypsea
1.14.14.154 Amphotericin B
-
 Pichia kudriavzevii
1.14.14.154 Amphotericin B
-
 Trichophyton rubrum
1.14.14.154 butyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate exhibits higher activity than fluconazole Candida albicans
1.14.14.154 butyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate exhibits higher activity than fluconazole Pichia kudriavzevii
1.14.14.154 butyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate exhibits higher activity than fluconazole Trichophyton rubrum
1.14.14.154 ethyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate exhibits higher activity than fluconazole Candida albicans
1.14.14.154 ethyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate
-
 Candida tropicalis
1.14.14.154 ethyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate exhibits activity than fluconazole Nannizzia gypsea
1.14.14.154 ethyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate exhibits higher activity than fluconazole Pichia kudriavzevii
1.14.14.154 ethyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate exhibits higher activity than fluconazole Trichophyton rubrum
1.14.14.154 fluconazole binds to the active site of CYP51 via coordination of the N atom of the triazole nucleus with iron of the heme group Candida albicans
1.14.14.154 fluconazole binds to the active site of CYP51 via coordination of the N atom of the triazole nucleus with iron of the heme group Candida parapsilosis
1.14.14.154 fluconazole binds to the active site of CYP51 via coordination of the N atom of the triazole nucleus with iron of the heme group Candida tropicalis
1.14.14.154 fluconazole binds to the active site of CYP51 via coordination of the N atom of the triazole nucleus with iron of the heme group Cryptococcus neoformans
1.14.14.154 fluconazole binds to the active site of CYP51 via coordination of the N atom of the triazole nucleus with iron of the heme group Nannizzia gypsea
1.14.14.154 fluconazole binds to the active site of CYP51 via coordination of the N atom of the triazole nucleus with iron of the heme group Pichia kudriavzevii
1.14.14.154 fluconazole binds to the active site of CYP51 via coordination of the N atom of the triazole nucleus with iron of the heme group Trichophyton rubrum
1.14.14.154 isobutyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate exhibits higher activity than fluconazole Candida parapsilosis
1.14.14.154 isobutyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate exhibits higher activity than fluconazole Nannizzia gypsea
1.14.14.154 isobutyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate exhibits higher activity than fluconazole Pichia kudriavzevii
1.14.14.154 isobutyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate exhibits higher activity than fluconazole Trichophyton rubrum
1.14.14.154 isopropyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate exhibits higher activity than fluconazole Candida albicans
1.14.14.154 isopropyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate exhibits higher activity than fluconazole Nannizzia gypsea
1.14.14.154 isopropyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate exhibits higher activity than fluconazole Pichia kudriavzevii
1.14.14.154 isopropyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate exhibits higher activity than fluconazole Trichophyton rubrum
1.14.14.154 itraconazole
-
 Aspergillus fumigatus
1.14.14.154 itraconazole
-
 Candida albicans
1.14.14.154 itraconazole
-
 Candida parapsilosis
1.14.14.154 itraconazole
-
 Candida tropicalis
1.14.14.154 itraconazole
-
 Cryptococcus neoformans
1.14.14.154 itraconazole
-
 Nannizzia gypsea
1.14.14.154 itraconazole
-
 Pichia kudriavzevii
1.14.14.154 itraconazole
-
 Trichophyton rubrum
1.14.14.154 ketoconazole
-
 Aspergillus fumigatus
1.14.14.154 ketoconazole
-
 Candida albicans
1.14.14.154 ketoconazole
-
 Candida parapsilosis
1.14.14.154 ketoconazole
-
 Candida tropicalis
1.14.14.154 ketoconazole
-
 Cryptococcus neoformans
1.14.14.154 ketoconazole
-
 Nannizzia gypsea
1.14.14.154 ketoconazole
-
 Pichia kudriavzevii
1.14.14.154 ketoconazole
-
 Trichophyton rubrum
1.14.14.154 methyl-2-[4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-amino)-methyl)-benzoyloxy]-benzoate exhibits higher activity than fluconazole Candida albicans
1.14.14.154 methyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate exhibits higher activity than fluconazole Candida albicans
1.14.14.154 methyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate exhibits higher activity than fluconazole Candida parapsilosis
1.14.14.154 methyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate
-
 Candida tropicalis
1.14.14.154 methyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate exhibits higher activity than fluconazole Cryptococcus neoformans
1.14.14.154 methyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate exhibits higher activity than fluconazole Nannizzia gypsea
1.14.14.154 methyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate exhibits higher activity than fluconazole Pichia kudriavzevii
1.14.14.154 methyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate exhibits higher activity than fluconazole Trichophyton rubrum
1.14.14.154 additional information is not inhibited by fluconazole, amphotericin B, 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-benzyl-amino]-2-propanol, 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-fluorobenzyl)-amino]-2-propanol, 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(3-fluorobenzyl)-amino]-2-propanol, 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-fluorobenzyl)-amino]-2-propanol, 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-chlorobenzyl)-amino]-2-propanol, 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(3-chlorobenzyl)-amino]-2-propanol, 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-chlorobenzyl)-amino]-2-propanol, 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-bromobenzyl)-amino]-2-propanol, 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-bromobenzyl)-amino]-2-propanol, 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2-methylbenzyl)-amino]-2-propanol, 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-methylbenzyl)-amino]-2-propanol, 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-nitrobenzyl)-amino]-2-propanol, 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(4-ethylbenzyl)-amino]-2-propanol, 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-[N-allyl-N-(2,4-dichlorobenzyl)-amino]-2-propanol, methyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate, ethyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate, isopropyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate, isopropyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate, isobutyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate, pentyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate, phenyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate, 3-nitrophenyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-amino)-methyl)-benzoate, 4-nitrophenyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-amino)-methyl)-benzoate, 4-chlorophenyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-amino)-methyl)-benzoate, methyl-2-[4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-amino)-methyl)-benzoyloxy]-benzoate or 4-(propoxycarbonyl)-phenyl-[4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]amino)methyl)]benzoate Aspergillus fumigatus
1.14.14.154 additional information inhibition of CYP51 involves a coordination bond with iron of the heme group, the hydrophilic H-bonding region, the hydrophobic region, and the narrow hydrophobic cleft Candida albicans
1.14.14.154 additional information inhibition of CYP51 involves a coordination bond with iron of the heme group, the hydrophilic H-bonding region, the hydrophobic region, and the narrow hydrophobic cleft Candida parapsilosis
1.14.14.154 additional information inhibition of CYP51 involves a coordination bond with iron of the heme group, the hydrophilic H-bonding region, the hydrophobic region, and the narrow hydrophobic cleft Candida tropicalis
1.14.14.154 additional information inhibition of CYP51 involves a coordination bond with iron of the heme group, the hydrophilic H-bonding region, the hydrophobic region, and the narrow hydrophobic cleft Cryptococcus neoformans
1.14.14.154 additional information inhibition of CYP51 involves a coordination bond with iron of the heme group, the hydrophilic H-bonding region, the hydrophobic region, and the narrow hydrophobic cleft Nannizzia gypsea
1.14.14.154 additional information inhibition of CYP51 involves a coordination bond with iron of the heme group, the hydrophilic H-bonding region, the hydrophobic region, and the narrow hydrophobic cleft Pichia kudriavzevii
1.14.14.154 pentyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate exhibits higher activity than fluconazole Pichia kudriavzevii
1.14.14.154 pentyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate exhibits higher activity than fluconazole Trichophyton rubrum
1.14.14.154 phenyl-4-((allyl[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazole-1-yl)-propyl]-amino)-methyl)-benzoate exhibits higher activity than fluconazole Pichia kudriavzevii
1.14.14.154 terbinafine
-
 Aspergillus fumigatus
1.14.14.154 terbinafine
-
 Candida albicans
1.14.14.154 terbinafine
-
 Candida parapsilosis
1.14.14.154 terbinafine
-
 Candida tropicalis
1.14.14.154 terbinafine
-
 Cryptococcus neoformans
1.14.14.154 terbinafine
-
 Nannizzia gypsea
1.14.14.154 terbinafine
-
 Pichia kudriavzevii
1.14.14.154 terbinafine
-
 Trichophyton rubrum
1.14.14.154 voriconazole
-
 Aspergillus fumigatus
1.14.14.154 voriconazole
-
 Candida albicans
1.14.14.154 voriconazole
-
 Candida parapsilosis
1.14.14.154 voriconazole
-
 Candida tropicalis
1.14.14.154 voriconazole
-
 Cryptococcus neoformans
1.14.14.154 voriconazole
-
 Nannizzia gypsea
1.14.14.154 voriconazole
-
 Pichia kudriavzevii
1.14.14.154 voriconazole
-
 Trichophyton rubrum

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.154 Aspergillus fumigatus
-
-
-
1.14.14.154 Candida albicans
-
 strain ATCC7661
-
1.14.14.154 Candida albicans ATCC 7661
-
 strain ATCC7661
-
1.14.14.154 Candida parapsilosis
-
-
-
1.14.14.154 Candida tropicalis
-
-
-
1.14.14.154 Cryptococcus neoformans
-
-
-
1.14.14.154 Nannizzia gypsea
-
-
-
1.14.14.154 Pichia kudriavzevii
-
-
-
1.14.14.154 Trichophyton rubrum
-
-
-

Synonyms

EC Number Synonyms Comment Organism
1.14.14.154 CYP51
-
 Pichia kudriavzevii
1.14.14.154 CYP51
-
 Candida albicans
1.14.14.154 CYP51
-
 Candida tropicalis
1.14.14.154 CYP51
-
 Cryptococcus neoformans
1.14.14.154 CYP51
-
 Candida parapsilosis
1.14.14.154 CYP51
-
 Aspergillus fumigatus
1.14.14.154 CYP51
-
 Trichophyton rubrum
1.14.14.154 CYP51
-
 Nannizzia gypsea
1.14.14.154 cytochrome P450 14alpha-demethylase
-
 Pichia kudriavzevii
1.14.14.154 cytochrome P450 14alpha-demethylase
-
 Candida albicans
1.14.14.154 cytochrome P450 14alpha-demethylase
-
 Candida tropicalis
1.14.14.154 cytochrome P450 14alpha-demethylase
-
 Cryptococcus neoformans
1.14.14.154 cytochrome P450 14alpha-demethylase
-
 Candida parapsilosis
1.14.14.154 cytochrome P450 14alpha-demethylase
-
 Aspergillus fumigatus
1.14.14.154 cytochrome P450 14alpha-demethylase
-
 Trichophyton rubrum
1.14.14.154 cytochrome P450 14alpha-demethylase
-
 Nannizzia gypsea