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Literature summary extracted from

  • Pegg, A.E.
    S-Adenosylmethionine decarboxylase (2009), Essays Biochem., 46, 25-45.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.1.1.50 additional information not activated by putrescine Solanum tuberosum
4.1.1.50 pi' subunit
-
 Trypanosoma brucei
4.1.1.50 pi' subunit
-
 Trypanosoma cruzi
4.1.1.50 putrescine
-
 Homo sapiens
4.1.1.50 putrescine
-
 Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.50 (S)-(5'-deoxy-5'-adenosyl)methylthioethylhydroxylamine
-
 Bacillus subtilis
4.1.1.50 (S)-(5'-deoxy-5'-adenosyl)methylthioethylhydroxylamine
-
 Catharanthus roseus
4.1.1.50 (S)-(5'-deoxy-5'-adenosyl)methylthioethylhydroxylamine
-
 Clostridium acetobutylicum
4.1.1.50 (S)-(5'-deoxy-5'-adenosyl)methylthioethylhydroxylamine
-
 Escherichia coli
4.1.1.50 (S)-(5'-deoxy-5'-adenosyl)methylthioethylhydroxylamine
-
 Homo sapiens
4.1.1.50 (S)-(5'-deoxy-5'-adenosyl)methylthioethylhydroxylamine
-
 Methanocaldococcus jannaschii
4.1.1.50 (S)-(5'-deoxy-5'-adenosyl)methylthioethylhydroxylamine
-
 Saccharomyces cerevisiae
4.1.1.50 (S)-(5'-deoxy-5'-adenosyl)methylthioethylhydroxylamine
-
 Solanum tuberosum
4.1.1.50 (S)-(5'-deoxy-5'-adenosyl)methylthioethylhydroxylamine
-
 Thermotoga maritima
4.1.1.50 (S)-(5'-deoxy-5'-adenosyl)methylthioethylhydroxylamine
-
 Trypanosoma brucei
4.1.1.50 (S)-(5'-deoxy-5'-adenosyl)methylthioethylhydroxylamine
-
 Trypanosoma cruzi
4.1.1.50 5'-deoxy-5'-dimethylsulfonio-8-methyladenosine
-
 Bacillus subtilis
4.1.1.50 5'-deoxy-5'-dimethylsulfonio-8-methyladenosine
-
 Catharanthus roseus
4.1.1.50 5'-deoxy-5'-dimethylsulfonio-8-methyladenosine
-
 Clostridium acetobutylicum
4.1.1.50 5'-deoxy-5'-dimethylsulfonio-8-methyladenosine
-
 Escherichia coli
4.1.1.50 5'-deoxy-5'-dimethylsulfonio-8-methyladenosine
-
 Homo sapiens
4.1.1.50 5'-deoxy-5'-dimethylsulfonio-8-methyladenosine
-
 Methanocaldococcus jannaschii
4.1.1.50 5'-deoxy-5'-dimethylsulfonio-8-methyladenosine
-
 Saccharomyces cerevisiae
4.1.1.50 5'-deoxy-5'-dimethylsulfonio-8-methyladenosine
-
 Solanum tuberosum
4.1.1.50 5'-deoxy-5'-dimethylsulfonio-8-methyladenosine
-
 Thermotoga maritima
4.1.1.50 5'-deoxy-5'-dimethylsulfonio-8-methyladenosine
-
 Trypanosoma brucei
4.1.1.50 5'-deoxy-5'-dimethylsulfonio-8-methyladenosine
-
 Trypanosoma cruzi
4.1.1.50 5'-deoxy-5'-[(2-aminooxyethyl)methylamino]adenosine
-
 Bacillus subtilis
4.1.1.50 5'-deoxy-5'-[(2-aminooxyethyl)methylamino]adenosine
-
 Catharanthus roseus
4.1.1.50 5'-deoxy-5'-[(2-aminooxyethyl)methylamino]adenosine
-
 Clostridium acetobutylicum
4.1.1.50 5'-deoxy-5'-[(2-aminooxyethyl)methylamino]adenosine
-
 Escherichia coli
4.1.1.50 5'-deoxy-5'-[(2-aminooxyethyl)methylamino]adenosine
-
 Homo sapiens
4.1.1.50 5'-deoxy-5'-[(2-aminooxyethyl)methylamino]adenosine
-
 Methanocaldococcus jannaschii
4.1.1.50 5'-deoxy-5'-[(2-aminooxyethyl)methylamino]adenosine
-
 Saccharomyces cerevisiae
4.1.1.50 5'-deoxy-5'-[(2-aminooxyethyl)methylamino]adenosine
-
 Solanum tuberosum
4.1.1.50 5'-deoxy-5'-[(2-aminooxyethyl)methylamino]adenosine
-
 Thermotoga maritima
4.1.1.50 5'-deoxy-5'-[(2-aminooxyethyl)methylamino]adenosine
-
 Trypanosoma brucei
4.1.1.50 5'-deoxy-5'-[(2-aminooxyethyl)methylamino]adenosine
-
 Trypanosoma cruzi
4.1.1.50 5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine
-
 Bacillus subtilis
4.1.1.50 5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine
-
 Catharanthus roseus
4.1.1.50 5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine
-
 Clostridium acetobutylicum
4.1.1.50 5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine
-
 Escherichia coli
4.1.1.50 5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine
-
 Homo sapiens
4.1.1.50 5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine
-
 Methanocaldococcus jannaschii
4.1.1.50 5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine
-
 Saccharomyces cerevisiae
4.1.1.50 5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine
-
 Solanum tuberosum
4.1.1.50 5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine
-
 Thermotoga maritima
4.1.1.50 5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine
-
 Trypanosoma brucei
4.1.1.50 5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine
-
 Trypanosoma cruzi
4.1.1.50 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine MDL 73811 Bacillus subtilis
4.1.1.50 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine MDL 73811 Catharanthus roseus
4.1.1.50 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine MDL 73811 Clostridium acetobutylicum
4.1.1.50 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine MDL 73811 Escherichia coli
4.1.1.50 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine MDL 73811 Homo sapiens
4.1.1.50 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine MDL 73811 Methanocaldococcus jannaschii
4.1.1.50 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine MDL 73811 Saccharomyces cerevisiae
4.1.1.50 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine MDL 73811 Solanum tuberosum
4.1.1.50 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine MDL 73811 Thermotoga maritima
4.1.1.50 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine MDL 73811 Trypanosoma brucei
4.1.1.50 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine MDL 73811 Trypanosoma cruzi
4.1.1.50 Genz-644131 i.e. 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxy-8-methyladenosine Bacillus subtilis
4.1.1.50 Genz-644131 i.e. 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxy-8-methyladenosine Catharanthus roseus
4.1.1.50 Genz-644131 i.e. 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxy-8-methyladenosine Clostridium acetobutylicum
4.1.1.50 Genz-644131 i.e. 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxy-8-methyladenosine Escherichia coli
4.1.1.50 Genz-644131 i.e. 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxy-8-methyladenosine Homo sapiens
4.1.1.50 Genz-644131 i.e. 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxy-8-methyladenosine Methanocaldococcus jannaschii
4.1.1.50 Genz-644131 i.e. 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxy-8-methyladenosine Saccharomyces cerevisiae
4.1.1.50 Genz-644131 i.e. 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxy-8-methyladenosine Solanum tuberosum
4.1.1.50 Genz-644131 i.e. 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxy-8-methyladenosine Thermotoga maritima
4.1.1.50 Genz-644131 i.e. 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxy-8-methyladenosine Trypanosoma brucei
4.1.1.50 Genz-644131 i.e. 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxy-8-methyladenosine Trypanosoma cruzi
4.1.1.50 methylglyoxal bis(guanylhydrazone)
-
 Bacillus subtilis
4.1.1.50 methylglyoxal bis(guanylhydrazone)
-
 Catharanthus roseus
4.1.1.50 methylglyoxal bis(guanylhydrazone)
-
 Clostridium acetobutylicum
4.1.1.50 methylglyoxal bis(guanylhydrazone)
-
 Escherichia coli
4.1.1.50 methylglyoxal bis(guanylhydrazone)
-
 Homo sapiens
4.1.1.50 methylglyoxal bis(guanylhydrazone)
-
 Methanocaldococcus jannaschii
4.1.1.50 methylglyoxal bis(guanylhydrazone)
-
 Saccharomyces cerevisiae
4.1.1.50 methylglyoxal bis(guanylhydrazone)
-
 Solanum tuberosum
4.1.1.50 methylglyoxal bis(guanylhydrazone)
-
 Thermotoga maritima
4.1.1.50 methylglyoxal bis(guanylhydrazone)
-
 Trypanosoma brucei
4.1.1.50 methylglyoxal bis(guanylhydrazone)
-
 Trypanosoma cruzi
4.1.1.50 SAM486A previously described as CGP4864A, i.e. 4-amidinoindan-1-one-2'-amidinohydrazone Bacillus subtilis
4.1.1.50 SAM486A previously described as CGP4864A, i.e. 4-amidinoindan-1-one-2'-amidinohydrazone Catharanthus roseus
4.1.1.50 SAM486A previously described as CGP4864A, i.e. 4-amidinoindan-1-one-2'-amidinohydrazone Clostridium acetobutylicum
4.1.1.50 SAM486A previously described as CGP4864A, i.e. 4-amidinoindan-1-one-2'-amidinohydrazone Escherichia coli
4.1.1.50 SAM486A previously described as CGP4864A, i.e. 4-amidinoindan-1-one-2'-amidinohydrazone Homo sapiens
4.1.1.50 SAM486A previously described as CGP4864A, i.e. 4-amidinoindan-1-one-2'-amidinohydrazone Methanocaldococcus jannaschii
4.1.1.50 SAM486A previously described as CGP4864A, i.e. 4-amidinoindan-1-one-2'-amidinohydrazone Saccharomyces cerevisiae
4.1.1.50 SAM486A previously described as CGP4864A, i.e. 4-amidinoindan-1-one-2'-amidinohydrazone Solanum tuberosum
4.1.1.50 SAM486A previously described as CGP4864A, i.e. 4-amidinoindan-1-one-2'-amidinohydrazone Thermotoga maritima
4.1.1.50 SAM486A previously described as CGP4864A, i.e. 4-amidinoindan-1-one-2'-amidinohydrazone Trypanosoma brucei
4.1.1.50 SAM486A previously described as CGP4864A, i.e. 4-amidinoindan-1-one-2'-amidinohydrazone Trypanosoma cruzi

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.1.1.50 Mg2+ required Escherichia coli
4.1.1.50 Mg2+ required Clostridium acetobutylicum
4.1.1.50 additional information does not require Mg2+ for activity Bacillus subtilis
4.1.1.50 additional information does not require Mg2+ for activity Homo sapiens
4.1.1.50 additional information does not require Mg2+ for activity Saccharomyces cerevisiae
4.1.1.50 additional information does not require Mg2+ for activity Solanum tuberosum
4.1.1.50 additional information does not require Mg2+ for activity Trypanosoma brucei
4.1.1.50 additional information does not require Mg2+ for activity Trypanosoma cruzi
4.1.1.50 additional information does not require Mg2+ for activity Methanocaldococcus jannaschii
4.1.1.50 additional information does not require Mg2+ for activity Catharanthus roseus
4.1.1.50 additional information does not require Mg2+ for activity Thermotoga maritima

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.1.50 14000
-
 estimated from amino acid sequence Bacillus subtilis
4.1.1.50 14000
-
 estimated from amino acid sequence Methanocaldococcus jannaschii
4.1.1.50 15000
-
 estimated from amino acid sequence Thermotoga maritima
4.1.1.50 30000
-
 estimated from amino acid sequence Escherichia coli
4.1.1.50 32000
-
 estimated from amino acid sequence Clostridium acetobutylicum
4.1.1.50 38000
-
 estimated from amino acid sequence Homo sapiens
4.1.1.50 39000
-
 estimated from amino acid sequence Catharanthus roseus
4.1.1.50 40000
-
 estimated from amino acid sequence Solanum tuberosum
4.1.1.50 42000
-
 estimated from amino acid sequence Trypanosoma cruzi
4.1.1.50 44000
-
 estimated from amino acid sequence Trypanosoma brucei
4.1.1.50 46000
-
 estimated from amino acid sequence Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.50 Bacillus subtilis
-
-
-
4.1.1.50 Catharanthus roseus
-
-
-
4.1.1.50 Clostridium acetobutylicum
-
-
-
4.1.1.50 Escherichia coli
-
-
-
4.1.1.50 Homo sapiens
-
-
-
4.1.1.50 Methanocaldococcus jannaschii
-
-
-
4.1.1.50 Saccharomyces cerevisiae
-
-
-
4.1.1.50 Solanum tuberosum
-
-
-
4.1.1.50 Thermotoga maritima
-
-
-
4.1.1.50 Trypanosoma brucei
-
-
-
4.1.1.50 Trypanosoma cruzi
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.50 S-adenosyl-L-methionine
-
 Bacillus subtilis (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
 ?
4.1.1.50 S-adenosyl-L-methionine
-
 Escherichia coli (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
 ?
4.1.1.50 S-adenosyl-L-methionine
-
 Homo sapiens (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
 ?
4.1.1.50 S-adenosyl-L-methionine
-
 Saccharomyces cerevisiae (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
 ?
4.1.1.50 S-adenosyl-L-methionine
-
 Solanum tuberosum (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
 ?
4.1.1.50 S-adenosyl-L-methionine
-
 Trypanosoma brucei (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
 ?
4.1.1.50 S-adenosyl-L-methionine
-
 Trypanosoma cruzi (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
 ?
4.1.1.50 S-adenosyl-L-methionine
-
 Clostridium acetobutylicum (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
 ?
4.1.1.50 S-adenosyl-L-methionine
-
 Methanocaldococcus jannaschii (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
 ?
4.1.1.50 S-adenosyl-L-methionine
-
 Catharanthus roseus (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
 ?
4.1.1.50 S-adenosyl-L-methionine
-
 Thermotoga maritima (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
4.1.1.50 heterodimer x-ray crystallography Bacillus subtilis
4.1.1.50 heterodimer x-ray crystallography Escherichia coli
4.1.1.50 heterodimer x-ray crystallography Homo sapiens
4.1.1.50 heterodimer x-ray crystallography Saccharomyces cerevisiae
4.1.1.50 heterodimer x-ray crystallography Solanum tuberosum
4.1.1.50 heterodimer x-ray crystallography Trypanosoma brucei
4.1.1.50 heterodimer x-ray crystallography Trypanosoma cruzi
4.1.1.50 heterodimer x-ray crystallography Clostridium acetobutylicum
4.1.1.50 heterodimer x-ray crystallography Methanocaldococcus jannaschii
4.1.1.50 heterodimer x-ray crystallography Catharanthus roseus
4.1.1.50 heterodimer x-ray crystallography Thermotoga maritima

Synonyms

EC Number Synonyms Comment Organism
4.1.1.50 AdoMet decarboxylase
-
 Bacillus subtilis
4.1.1.50 AdoMet decarboxylase
-
 Escherichia coli
4.1.1.50 AdoMet decarboxylase
-
 Homo sapiens
4.1.1.50 AdoMet decarboxylase
-
 Saccharomyces cerevisiae
4.1.1.50 AdoMet decarboxylase
-
 Solanum tuberosum
4.1.1.50 AdoMet decarboxylase
-
 Trypanosoma brucei
4.1.1.50 AdoMet decarboxylase
-
 Trypanosoma cruzi
4.1.1.50 AdoMet decarboxylase
-
 Clostridium acetobutylicum
4.1.1.50 AdoMet decarboxylase
-
 Methanocaldococcus jannaschii
4.1.1.50 AdoMet decarboxylase
-
 Catharanthus roseus
4.1.1.50 AdoMet decarboxylase
-
 Thermotoga maritima
4.1.1.50 AdoMetDC
-
 Bacillus subtilis
4.1.1.50 AdoMetDC
-
 Escherichia coli
4.1.1.50 AdoMetDC
-
 Homo sapiens
4.1.1.50 AdoMetDC
-
 Saccharomyces cerevisiae
4.1.1.50 AdoMetDC
-
 Solanum tuberosum
4.1.1.50 AdoMetDC
-
 Trypanosoma brucei
4.1.1.50 AdoMetDC
-
 Trypanosoma cruzi
4.1.1.50 AdoMetDC
-
 Clostridium acetobutylicum
4.1.1.50 AdoMetDC
-
 Methanocaldococcus jannaschii
4.1.1.50 AdoMetDC
-
 Catharanthus roseus
4.1.1.50 AdoMetDC
-
 Thermotoga maritima
4.1.1.50 S-Adenosylmethionine decarboxylase
-
 Bacillus subtilis
4.1.1.50 S-Adenosylmethionine decarboxylase
-
 Escherichia coli
4.1.1.50 S-Adenosylmethionine decarboxylase
-
 Homo sapiens
4.1.1.50 S-Adenosylmethionine decarboxylase
-
 Saccharomyces cerevisiae
4.1.1.50 S-Adenosylmethionine decarboxylase
-
 Solanum tuberosum
4.1.1.50 S-Adenosylmethionine decarboxylase
-
 Trypanosoma brucei
4.1.1.50 S-Adenosylmethionine decarboxylase
-
 Trypanosoma cruzi
4.1.1.50 S-Adenosylmethionine decarboxylase
-
 Clostridium acetobutylicum
4.1.1.50 S-Adenosylmethionine decarboxylase
-
 Methanocaldococcus jannaschii
4.1.1.50 S-Adenosylmethionine decarboxylase
-
 Catharanthus roseus
4.1.1.50 S-Adenosylmethionine decarboxylase
-
 Thermotoga maritima

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.50 pyridoxal 5'-phosphate
-
 Bacillus subtilis
4.1.1.50 pyridoxal 5'-phosphate
-
 Escherichia coli
4.1.1.50 pyridoxal 5'-phosphate
-
 Homo sapiens
4.1.1.50 pyridoxal 5'-phosphate
-
 Saccharomyces cerevisiae
4.1.1.50 pyridoxal 5'-phosphate
-
 Solanum tuberosum
4.1.1.50 pyridoxal 5'-phosphate
-
 Trypanosoma brucei
4.1.1.50 pyridoxal 5'-phosphate
-
 Trypanosoma cruzi
4.1.1.50 pyridoxal 5'-phosphate
-
 Clostridium acetobutylicum
4.1.1.50 pyridoxal 5'-phosphate
-
 Methanocaldococcus jannaschii
4.1.1.50 pyridoxal 5'-phosphate
-
 Catharanthus roseus
4.1.1.50 pyridoxal 5'-phosphate
-
 Thermotoga maritima

Expression

EC Number Organism Comment Expression
4.1.1.50 Bacillus subtilis AdoMetDC is negatively regulated by spermidine and spermine down
4.1.1.50 Escherichia coli AdoMetDC is negatively regulated by spermidine and spermine down
4.1.1.50 Homo sapiens AdoMetDC is negatively regulated by spermidine and spermine down
4.1.1.50 Saccharomyces cerevisiae AdoMetDC is negatively regulated by spermidine and spermine down
4.1.1.50 Solanum tuberosum AdoMetDC is negatively regulated by spermidine and spermine down
4.1.1.50 Trypanosoma brucei AdoMetDC is negatively regulated by spermidine and spermine down
4.1.1.50 Trypanosoma cruzi AdoMetDC is negatively regulated by spermidine and spermine down
4.1.1.50 Clostridium acetobutylicum AdoMetDC is negatively regulated by spermidine and spermine down
4.1.1.50 Methanocaldococcus jannaschii AdoMetDC is negatively regulated by spermidine and spermine down
4.1.1.50 Catharanthus roseus AdoMetDC is negatively regulated by spermidine and spermine down
4.1.1.50 Thermotoga maritima AdoMetDC is negatively regulated by spermidine and spermine down