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Literature summary extracted from

  • Rousset, X.; Vaisman, B.; Amar, M.; Sethi, A.; Remaley, A.
    Lecithin: cholesterol acyltransferase - from biochemistry to role in cardiovascular disease (2009), Curr. Opin. Endocrinol. Diabetes Obes., 16, 163-171.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.43 apolipoprotein A-I required Mus musculus
2.3.1.43 apolipoprotein A-I required Oryctolagus cuniculus
2.3.1.43 apolipoprotein A-I required, other apolipoprotein are less effective Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.43 additional information enzyme deficiency phenotypes, overview. Generation of transgenic mice, monkeys, or rabbits overexpressing the human LCAT Homo sapiens
2.3.1.43 additional information overexpression of LCAT does not protect against diet-induced atherosclerosis, but in contrary does increase the atherosclerosis risk. LCAT knockout mice show markedly reduced plasma total cholesterol, cholesteryl esters, HDL-C, apolipoprotein A-I, and an increase in plasma triglycerides, the amount of alpha-HDl is decreased compared to wild-type mice Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.43 sphingomyelin
-
 Homo sapiens
2.3.1.43 sphingomyelin
-
 Mus musculus
2.3.1.43 sphingomyelin
-
 Oryctolagus cuniculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.43 extracellular
-
 Mus musculus
-
-
2.3.1.43 extracellular
-
 Homo sapiens
-
-
2.3.1.43 extracellular
-
 Oryctolagus cuniculus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.43 additional information Homo sapiens about 75% of plasma LCAT is associated with HDL ?
-
 ?
2.3.1.43 phosphatidylcholine + cholesterol Mus musculus
-
 cholesteryl ester + lysophosphatidylcholine
-
 ?
2.3.1.43 phosphatidylcholine + cholesterol Homo sapiens
-
 cholesteryl ester + lysophosphatidylcholine
-
 ?
2.3.1.43 phosphatidylcholine + cholesterol Oryctolagus cuniculus
-
 cholesteryl ester + lysophosphatidylcholine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.43 Homo sapiens
-
 gene lcat
-
2.3.1.43 Mus musculus
-
 gene lcat
-
2.3.1.43 Oryctolagus cuniculus
-
 gene lcat
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.43 blood plasma
-
 Mus musculus
-
2.3.1.43 blood plasma
-
 Oryctolagus cuniculus
-
2.3.1.43 blood plasma about 75% of plasma LCAT is associated with HDL Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.43 additional information about 75% of plasma LCAT is associated with HDL Homo sapiens ?
-
 ?
2.3.1.43 additional information the human enzyme prefers phospholipids with 18:1 or 18:2 fatty acids Homo sapiens ?
-
 ?
2.3.1.43 additional information the mouse enzyme prefers phospholipids with 20:4 fatty acids Mus musculus ?
-
 ?
2.3.1.43 phosphatidylcholine + cholesterol
-
 Mus musculus cholesteryl ester + lysophosphatidylcholine
-
 ?
2.3.1.43 phosphatidylcholine + cholesterol
-
 Homo sapiens cholesteryl ester + lysophosphatidylcholine
-
 ?
2.3.1.43 phosphatidylcholine + cholesterol
-
 Oryctolagus cuniculus cholesteryl ester + lysophosphatidylcholine
-
 ?
2.3.1.43 phosphatidylcholine + cholesterol in a first step, LCAT hydrolyzes the sn-2 acyl group of phosphatidylcholine and binds it at Ser181. In a second step, the enzyme transfers and esterifies the fatty acid to the 3beta-hydroxyl group on the A-ring of free cholesterol to form cholesteryl ester using apolipoprotein A-I as cofactor Mus musculus cholesteryl ester + lysophosphatidylcholine
-
 ?
2.3.1.43 phosphatidylcholine + cholesterol in a first step, LCAT hydrolyzes the sn-2 acyl group of phosphatidylcholine and binds it at Ser181. In a second step, the enzyme transfers and esterifies the fatty acid to the 3beta-hydroxyl group on the A-ring of free cholesterol to form cholesteryl ester using apolipoprotein A-I as cofactor Homo sapiens cholesteryl ester + lysophosphatidylcholine
-
 ?
2.3.1.43 phosphatidylcholine + cholesterol in a first step, LCAT hydrolyzes the sn-2 acyl group of phosphatidylcholine and binds it at Ser181. In a second step, the enzyme transfers and esterifies the fatty acid to the 3beta-hydroxyl group on the A-ring of free cholesterol to form cholesteryl ester using apolipoprotein A-I as cofactor Oryctolagus cuniculus cholesteryl ester + lysophosphatidylcholine
-
 ?
2.3.1.43 phosphatidylethanolamine + cholesterol
-
 Mus musculus cholesteryl ester + lysophosphatidylethanolamine
-
 ?
2.3.1.43 phosphatidylethanolamine + cholesterol
-
 Homo sapiens cholesteryl ester + lysophosphatidylethanolamine
-
 ?
2.3.1.43 phosphatidylethanolamine + cholesterol
-
 Oryctolagus cuniculus cholesteryl ester + lysophosphatidylethanolamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.43 LCAT
-
 Mus musculus
2.3.1.43 LCAT
-
 Homo sapiens
2.3.1.43 LCAT
-
 Oryctolagus cuniculus
2.3.1.43 lecithin: cholesterol acyltransferase
-
 Mus musculus
2.3.1.43 lecithin: cholesterol acyltransferase
-
 Homo sapiens
2.3.1.43 lecithin: cholesterol acyltransferase
-
 Oryctolagus cuniculus

General Information

EC Number General Information Comment Organism
2.3.1.43 malfunction inborn enzyme deficiency leads to the fish-eye disease, as well as anemia, proteinuria, renal failure, hepatosplenomegaly, and lymphadenopathy Homo sapiens
2.3.1.43 physiological function LCAT might have a beneficial role in reducing atherosclerosis Mus musculus
2.3.1.43 physiological function LCAT might have a beneficial role in reducing atherosclerosis Homo sapiens
2.3.1.43 physiological function LCAT might have a beneficial role in reducing atherosclerosis Oryctolagus cuniculus