Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Do, R.; Kiss, R.S.; Gaudet, D.; Engert, J.C.
    Squalene synthase: a critical enzyme in the cholesterol biosynthesis pathway (2009), Clin. Genet., 75, 19-29.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.5.1.21 K45R mutation with influence on total cholesterol and non-HDL-C levels Cavia porcellus
2.5.1.21 K45R mutation with influence on total cholesterol and non-HDL-C levels Mus musculus
2.5.1.21 K45R mutation with influence on total cholesterol and non-HDL-C levels Homo sapiens
2.5.1.21 K45R mutation with influence on total cholesterol and non-HDL-C levels Oryctolagus cuniculus
2.5.1.21 K45R mutation with influence on total cholesterol and non-HDL-C levels Macaca mulatta

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.21 atorvastatin
-
 Homo sapiens
2.5.1.21 BMS-188494
-
 Homo sapiens
2.5.1.21 RPR107393
-
 Homo sapiens
2.5.1.21 RPR107393 inhibition of cholesterol biosynthesis and reduced plasma total cholesterol levels Rattus norvegicus
2.5.1.21 T-91485
-
 Homo sapiens
2.5.1.21 TAK-475
-
 Homo sapiens
2.5.1.21 TAK-475
-
 Mus musculus
2.5.1.21 TAK-475
-
 Oryctolagus cuniculus
2.5.1.21 YM-53601 reduction of non-high-density lipoprotein cholesterol concentrations Cavia porcellus
2.5.1.21 YM-53601 reduction of non-high-density lipoprotein cholesterol concentrations Macaca mulatta
2.5.1.21 zaragozic acid
-
 Homo sapiens
2.5.1.21 zaragozic acid decrease in plasma cholesterol Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.5.1.21 endoplasmic reticulum
-
 Cavia porcellus 5783
-
2.5.1.21 endoplasmic reticulum
-
 Mus musculus 5783
-
2.5.1.21 endoplasmic reticulum
-
 Homo sapiens 5783
-
2.5.1.21 endoplasmic reticulum
-
 Rattus norvegicus 5783
-
2.5.1.21 endoplasmic reticulum
-
 Oryctolagus cuniculus 5783
-
2.5.1.21 endoplasmic reticulum
-
 Macaca mulatta 5783
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.5.1.21 Mg2+ cofactor Cavia porcellus
2.5.1.21 Mg2+ cofactor Mus musculus
2.5.1.21 Mg2+ cofactor Homo sapiens
2.5.1.21 Mg2+ cofactor Rattus norvegicus
2.5.1.21 Mg2+ cofactor Oryctolagus cuniculus
2.5.1.21 Mg2+ cofactor Macaca mulatta

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.21 2 farnesyl diphosphate Cavia porcellus
-
 presqualene diphosphate + diphosphate
-
 ?
2.5.1.21 2 farnesyl diphosphate Mus musculus
-
 presqualene diphosphate + diphosphate
-
 ?
2.5.1.21 2 farnesyl diphosphate Homo sapiens
-
 presqualene diphosphate + diphosphate
-
 ?
2.5.1.21 2 farnesyl diphosphate Rattus norvegicus
-
 presqualene diphosphate + diphosphate
-
 ?
2.5.1.21 2 farnesyl diphosphate Oryctolagus cuniculus
-
 presqualene diphosphate + diphosphate
-
 ?
2.5.1.21 2 farnesyl diphosphate Macaca mulatta
-
 presqualene diphosphate + diphosphate
-
 ?
2.5.1.21 presqualene diphosphate + NAD(P)H + H+ Cavia porcellus
-
 squalene + diphosphate + NAD(P)+
-
 ?
2.5.1.21 presqualene diphosphate + NAD(P)H + H+ Mus musculus
-
 squalene + diphosphate + NAD(P)+
-
 ?
2.5.1.21 presqualene diphosphate + NAD(P)H + H+ Homo sapiens
-
 squalene + diphosphate + NAD(P)+
-
 ?
2.5.1.21 presqualene diphosphate + NAD(P)H + H+ Rattus norvegicus
-
 squalene + diphosphate + NAD(P)+
-
 ?
2.5.1.21 presqualene diphosphate + NAD(P)H + H+ Macaca mulatta
-
 squalene + diphosphate + NAD(P)+
-
 ?
2.5.1.21 presqualene diphosphate + NADPH + H+ Oryctolagus cuniculus
-
 squalene + diphosphate + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.21 Cavia porcellus
-
-
-
2.5.1.21 Homo sapiens
-
-
-
2.5.1.21 Macaca mulatta
-
-
-
2.5.1.21 Mus musculus
-
-
-
2.5.1.21 Oryctolagus cuniculus
-
-
-
2.5.1.21 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.21 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.21 2 farnesyl diphosphate
-
 Cavia porcellus presqualene diphosphate + diphosphate
-
 ?
2.5.1.21 2 farnesyl diphosphate
-
 Mus musculus presqualene diphosphate + diphosphate
-
 ?
2.5.1.21 2 farnesyl diphosphate
-
 Homo sapiens presqualene diphosphate + diphosphate
-
 ?
2.5.1.21 2 farnesyl diphosphate
-
 Rattus norvegicus presqualene diphosphate + diphosphate
-
 ?
2.5.1.21 2 farnesyl diphosphate
-
 Oryctolagus cuniculus presqualene diphosphate + diphosphate
-
 ?
2.5.1.21 2 farnesyl diphosphate
-
 Macaca mulatta presqualene diphosphate + diphosphate
-
 ?
2.5.1.21 presqualene diphosphate + NAD(P)H + H+
-
 Cavia porcellus squalene + diphosphate + NAD(P)+
-
 ?
2.5.1.21 presqualene diphosphate + NAD(P)H + H+
-
 Mus musculus squalene + diphosphate + NAD(P)+
-
 ?
2.5.1.21 presqualene diphosphate + NAD(P)H + H+
-
 Homo sapiens squalene + diphosphate + NAD(P)+
-
 ?
2.5.1.21 presqualene diphosphate + NAD(P)H + H+
-
 Rattus norvegicus squalene + diphosphate + NAD(P)+
-
 ?
2.5.1.21 presqualene diphosphate + NAD(P)H + H+
-
 Macaca mulatta squalene + diphosphate + NAD(P)+
-
 ?
2.5.1.21 presqualene diphosphate + NADPH + H+
-
 Oryctolagus cuniculus squalene + diphosphate + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.21 farnesyldiphosphate farnesyltransferase 1
-
 Cavia porcellus
2.5.1.21 farnesyldiphosphate farnesyltransferase 1
-
 Mus musculus
2.5.1.21 farnesyldiphosphate farnesyltransferase 1
-
 Homo sapiens
2.5.1.21 farnesyldiphosphate farnesyltransferase 1
-
 Rattus norvegicus
2.5.1.21 farnesyldiphosphate farnesyltransferase 1
-
 Oryctolagus cuniculus
2.5.1.21 farnesyldiphosphate farnesyltransferase 1
-
 Macaca mulatta
2.5.1.21 FDFT1
-
 Cavia porcellus
2.5.1.21 FDFT1
-
 Mus musculus
2.5.1.21 FDFT1
-
 Homo sapiens
2.5.1.21 FDFT1
-
 Rattus norvegicus
2.5.1.21 FDFT1
-
 Oryctolagus cuniculus
2.5.1.21 FDFT1
-
 Macaca mulatta
2.5.1.21 squalene synthase
-
 Cavia porcellus
2.5.1.21 squalene synthase
-
 Mus musculus
2.5.1.21 squalene synthase
-
 Homo sapiens
2.5.1.21 squalene synthase
-
 Rattus norvegicus
2.5.1.21 squalene synthase
-
 Oryctolagus cuniculus
2.5.1.21 squalene synthase
-
 Macaca mulatta

General Information

EC Number General Information Comment Organism
2.5.1.21 metabolism part of cholesterol biosynthesis pathway Cavia porcellus
2.5.1.21 metabolism part of cholesterol biosynthesis pathway Mus musculus
2.5.1.21 metabolism part of cholesterol biosynthesis pathway Homo sapiens
2.5.1.21 metabolism part of cholesterol biosynthesis pathway Rattus norvegicus
2.5.1.21 metabolism part of cholesterol biosynthesis pathway Oryctolagus cuniculus
2.5.1.21 metabolism part of cholesterol biosynthesis pathway Macaca mulatta
2.5.1.21 physiological function essential role in embryonic development Mus musculus