Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Rader, D.
    Lecithin: cholesterol acyltransferase and atherosclerosis: another high-density lipoprotein story that doesnt quite follow the script (2009), Circulation, 120, 549-552.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.43 apolipoprotein A-I
-
 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.43 additional information loss-of-function LCAT mutants show highly decreased HDL-cholesteryl ester plasma levels and inability to form mature HDL particles, leading to progressive renal insufficiency, up to end-stage renal disease A, and corneal opacification, as well as to hemolytic anemia, phenotype of heterozygotes and homozygotes Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.43 extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.43 phosphatidylcholine + cholesterol Homo sapiens LCAT is critical in the metabolism of HDL cholesteryl ester + lysophosphatidylcholine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.43 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.43 blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.43 phosphatidylcholine + cholesterol LCAT is critical in the metabolism of HDL Homo sapiens cholesteryl ester + lysophosphatidylcholine
-
 ?
2.3.1.43 phosphatidylcholine + cholesterol LCAT hydrolyzes the sn-2 acyl group of phosphatidylcholine and subsequently transfers and esterifies the fatty acid to the beta3-hydroxyl group of free cholesterol using apolipoprotein A-I as cofactor Homo sapiens cholesteryl ester + lysophosphatidylcholine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.43 LCAT
-
 Homo sapiens
2.3.1.43 lecithin: cholesterol acyltransferase
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.3.1.43 malfunction native mutants show the fish-eye disease Homo sapiens
2.3.1.43 physiological function LCAT expression is inversely related to atherosclerosis, the enzyme is not atheroprotective Homo sapiens