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Literature summary extracted from

  • Inoue, R.; Jensen, L.J.; Jian, Z.; Shi, J.; Hai, L.; Lurie, A.I.; Henriksen, F.H.; Salomonsson, M.; Morita, H.; Kawarabayashi, Y.; Mori, M.; Mori, Y.; Ito, Y.
    Synergistic activation of vascular TRPC6 channel by receptor and mechanical stimulation via phospholipase C/diacylglycerol and phospholipase A2/omega-hydroxylase/20-HETE pathways (2009), Circ. Res., 104, 1399-1409.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.15.3 (E)-N'-(4-butyl-2-methylphenyl)-N-hydroxyformimidamide HET0016, almost completely abolishes hypotonic solutions- or 2,4,6-trinitrophenol-induced enhancement of receptor-activated cationic current I(TRPC6) Homo sapiens
1.14.15.3 (E)-N'-(4-butyl-2-methylphenyl)-N-hydroxyformimidamide HET0016, diminishes TRPC6-like channel activity in myocytes Rattus norvegicus
1.14.15.3 17-octadecynoic acid almost completely abolishes hypotonic solutions- or 2,4,6-trinitrophenol-induced enhancement of receptor-activated cationic current I(TRPC6) Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.15.3 cytosol
-
 Homo sapiens 5829
-
1.14.15.3 cytosol
-
 Rattus norvegicus 5829
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.15.3 Homo sapiens
-
-
-
1.14.15.3 Rattus norvegicus
-
 male sprague-dawley rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.15.3 A7r5 cell
-
 Rattus norvegicus
-
1.14.15.3 HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.15.3 arachidonic acid + NAD(P)H + H+ + O2
-
 Homo sapiens (5Z,8Z,11Z,14Z)-20-hydroxyeicosa-5,8,11,14-tetraenoic acid + NAD(P)+ + H2O
-
 ?
1.14.15.3 arachidonic acid + NAD(P)H + H+ + O2
-
 Rattus norvegicus (5Z,8Z,11Z,14Z)-20-hydroxyeicosa-5,8,11,14-tetraenoic acid + NAD(P)+ + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.15.3 omega hydroxylase
-
 Homo sapiens
1.14.15.3 omega hydroxylase
-
 Rattus norvegicus

General Information

EC Number General Information Comment Organism
1.14.15.3 physiological function simultaneous operation of receptor and mechanical stimulations may synergistically amplify transmembrane Ca2+ mobilization through the activation of the non-voltage-gated Ca2+ entry/depolarization channel TRPC6, thereby enhancing the vascular tone via phospholipase C/diacylglycerol and phospholipase A(2)/omega-hydroxylase/20-hydroxyeicosatetraenoic acid pathways Rattus norvegicus
1.14.15.3 physiological function simultaneous operation of receptor and mechanical stimulations may synergistically amplify transmembrane Ca2+ mobilization through the activation of the non-voltage-gated Ca2+ entry/depolarization channel TRPC6, thereby enhancing the vascular tone via phospholipase C/diacylglycerol and phospholipase A(2)/omega-hydroxylase/20-hydroxyeicosatetraenoic acid pathways. Activation of the cytosolic phospholipase A(2)/omega-hydroxylase cascade and consequent production of 20-hydroxyeicosatetraenoic acid is essential for the mechanical enhancement of receptor-activated TRPC6 current/channel activity Homo sapiens