EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
4.2.1.10 | (1R,2R,4S,5R)-1,4,5-trihydroxy-2-(4-methoxybenzyl)-3-oxocyclohexanecarboxylic acid | - |
Helicobacter pylori | |
4.2.1.10 | (1R,2R,4S,5R)-1,4,5-trihydroxy-2-(4-methoxybenzyl)-3-oxocyclohexanecarboxylic acid | - |
Mycobacterium tuberculosis | |
4.2.1.10 | (1R,2R,4S,5R)-1,4,5-trihydroxy-2-(4-methylbenzyl)-3-oxocyclohexanecarboxylic acid | - |
Helicobacter pylori | |
4.2.1.10 | (1R,2R,4S,5R)-1,4,5-trihydroxy-2-(4-methylbenzyl)-3-oxocyclohexanecarboxylic acid | - |
Mycobacterium tuberculosis | |
4.2.1.10 | (1R,2R,4S,5R)-1,4,5-trihydroxy-3-oxo-2-(prop-2-en-1-yl)cyclohexanecarboxylic acid | - |
Helicobacter pylori | |
4.2.1.10 | (1R,2R,4S,5R)-1,4,5-trihydroxy-3-oxo-2-(prop-2-en-1-yl)cyclohexanecarboxylic acid | - |
Mycobacterium tuberculosis | |
4.2.1.10 | (1R,2R,4S,5R)-1,4,5-trihydroxy-3-oxo-2-propylcyclohexanecarboxylic acid | - |
Helicobacter pylori | |
4.2.1.10 | (1R,2R,4S,5R)-1,4,5-trihydroxy-3-oxo-2-propylcyclohexanecarboxylic acid | - |
Mycobacterium tuberculosis | |
4.2.1.10 | (1R,2R,4S,5R)-2-(1-benzothiophen-5-yl)-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | - |
Helicobacter pylori | |
4.2.1.10 | (1R,2R,4S,5R)-2-(1-benzothiophen-5-yl)-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | - |
Mycobacterium tuberculosis | |
4.2.1.10 | (1R,2R,4S,5R)-2-benzyl-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | - |
Helicobacter pylori | |
4.2.1.10 | (1R,2R,4S,5R)-2-benzyl-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | - |
Mycobacterium tuberculosis | |
4.2.1.10 | (1R,2R,4S,5R)-2-[difluoro(pentafluorophenyl)methyl]-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | - |
Helicobacter pylori | |
4.2.1.10 | (1R,2R,4S,5R)-2-[difluoro(pentafluorophenyl)methyl]-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | - |
Mycobacterium tuberculosis | |
4.2.1.10 | (1R,2S,4S,5R)-1,4,5-trihydroxy-2-(4-methoxybenzyl)-3-oxocyclohexanecarboxylic acid | - |
Helicobacter pylori | |
4.2.1.10 | (1R,2S,4S,5R)-1,4,5-trihydroxy-2-(4-methoxybenzyl)-3-oxocyclohexanecarboxylic acid | - |
Mycobacterium tuberculosis | |
4.2.1.10 | (1R,2S,4S,5R)-1,4,5-trihydroxy-2-(4-methylbenzyl)-3-oxocyclohexanecarboxylic acid | - |
Helicobacter pylori | |
4.2.1.10 | (1R,2S,4S,5R)-1,4,5-trihydroxy-2-(4-methylbenzyl)-3-oxocyclohexanecarboxylic acid | - |
Mycobacterium tuberculosis | |
4.2.1.10 | (1R,2S,4S,5R)-1,4,5-trihydroxy-3-oxo-2-(prop-2-en-1-yl)cyclohexanecarboxylic acid | - |
Helicobacter pylori | |
4.2.1.10 | (1R,2S,4S,5R)-1,4,5-trihydroxy-3-oxo-2-(prop-2-en-1-yl)cyclohexanecarboxylic acid | - |
Mycobacterium tuberculosis | |
4.2.1.10 | (1R,2S,4S,5R)-2-(1-benzothiophen-5-yl)-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | - |
Helicobacter pylori | |
4.2.1.10 | (1R,2S,4S,5R)-2-(1-benzothiophen-5-yl)-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | - |
Mycobacterium tuberculosis | |
4.2.1.10 | (1R,2S,4S,5R)-2-benzyl-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | - |
Helicobacter pylori | |
4.2.1.10 | (1R,2S,4S,5R)-2-benzyl-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | - |
Mycobacterium tuberculosis | |
4.2.1.10 | (1R,2S,4S,5R)-2-[difluoro(pentafluorophenyl)methyl]-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | - |
Helicobacter pylori | |
4.2.1.10 | (1R,2S,4S,5R)-2-[difluoro(pentafluorophenyl)methyl]-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | - |
Mycobacterium tuberculosis |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.2.1.10 | 0.015 | - |
3-dehydroquinate | at pH 7.0, 25°C | Mycobacterium tuberculosis | |
4.2.1.10 | 0.48 | - |
3-dehydroquinate | at pH 7.0, 25°C | Helicobacter pylori |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.2.1.10 | Helicobacter pylori | Q48255 | - |
- |
4.2.1.10 | Mycobacterium tuberculosis | P9WPX7 | - |
- |
4.2.1.10 | Mycobacterium tuberculosis H37Rv | P9WPX7 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.2.1.10 | 3-dehydroquinate | - |
Helicobacter pylori | 3-dehydroshikimate + H2O | - |
r | |
4.2.1.10 | 3-dehydroquinate | - |
Mycobacterium tuberculosis | 3-dehydroshikimate + H2O | - |
r | |
4.2.1.10 | 3-dehydroquinate | - |
Mycobacterium tuberculosis H37Rv | 3-dehydroshikimate + H2O | - |
r |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
4.2.1.10 | DHQ2 | - |
Helicobacter pylori |
4.2.1.10 | DHQ2 | - |
Mycobacterium tuberculosis |
4.2.1.10 | Type II dehydroquinase | - |
Helicobacter pylori |
4.2.1.10 | Type II dehydroquinase | - |
Mycobacterium tuberculosis |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.2.1.10 | 0.06 | - |
3-dehydroquinate | at pH 7.0, 25°C | Helicobacter pylori | |
4.2.1.10 | 0.15 | - |
3-dehydroquinate | at pH 7.0, 25°C | Mycobacterium tuberculosis |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.2.1.10 | 0.000026 | - |
(1R,2R,4S,5R)-1,4,5-trihydroxy-2-(4-methoxybenzyl)-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HOAc | Mycobacterium tuberculosis | |
4.2.1.10 | 0.000028 | - |
(1R,2R,4S,5R)-2-(1-benzothiophen-5-yl)-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HOAc | Mycobacterium tuberculosis | |
4.2.1.10 | 0.000047 | - |
(1R,2R,4S,5R)-2-[difluoro(pentafluorophenyl)methyl]-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HOAc | Mycobacterium tuberculosis | |
4.2.1.10 | 0.000056 | - |
(1R,2S,4S,5R)-2-(1-benzothiophen-5-yl)-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HOAc | Mycobacterium tuberculosis | |
4.2.1.10 | 0.000074 | - |
(1R,2S,4S,5R)-2-[difluoro(pentafluorophenyl)methyl]-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HOAc | Mycobacterium tuberculosis | |
4.2.1.10 | 0.000089 | - |
(1R,2R,4S,5R)-1,4,5-trihydroxy-2-(4-methylbenzyl)-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HOAc | Mycobacterium tuberculosis | |
4.2.1.10 | 0.00009 | - |
(1R,2S,4S,5R)-1,4,5-trihydroxy-2-(4-methylbenzyl)-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HOAc | Mycobacterium tuberculosis | |
4.2.1.10 | 0.00009 | - |
(1R,2S,4S,5R)-2-benzyl-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HOAc | Mycobacterium tuberculosis | |
4.2.1.10 | 0.0001 | - |
(1R,2S,4S,5R)-1,4,5-trihydroxy-2-(4-methoxybenzyl)-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HOAc | Mycobacterium tuberculosis | |
4.2.1.10 | 0.0001 | - |
(1R,2R,4S,5R)-2-benzyl-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris·HCl | Mycobacterium tuberculosis | |
4.2.1.10 | 0.00016 | - |
(1R,2R,4S,5R)-2-(1-benzothiophen-5-yl)-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HCl | Helicobacter pylori | |
4.2.1.10 | 0.00017 | - |
(1R,2R,4S,5R)-1,4,5-trihydroxy-2-(4-methoxybenzyl)-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HCl | Helicobacter pylori | |
4.2.1.10 | 0.00025 | - |
(1R,2R,4S,5R)-1,4,5-trihydroxy-2-(4-methylbenzyl)-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HCl | Helicobacter pylori | |
4.2.1.10 | 0.00076 | - |
(1R,2R,4S,5R)-1,4,5-trihydroxy-3-oxo-2-(prop-2-en-1-yl)cyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HOAc | Mycobacterium tuberculosis | |
4.2.1.10 | 0.0009 | - |
(1R,2S,4S,5R)-2-(1-benzothiophen-5-yl)-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HCl | Helicobacter pylori | |
4.2.1.10 | 0.00097 | - |
(1R,2S,4S,5R)-1,4,5-trihydroxy-2-(4-methylbenzyl)-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HCl | Helicobacter pylori | |
4.2.1.10 | 0.00097 | - |
(1R,2S,4S,5R)-2-[difluoro(pentafluorophenyl)methyl]-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HCl | Helicobacter pylori | |
4.2.1.10 | 0.00118 | - |
(1R,2S,4S,5R)-2-benzyl-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HCl | Helicobacter pylori | |
4.2.1.10 | 0.0014 | - |
(1R,2R,4S,5R)-2-benzyl-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HCl | Helicobacter pylori | |
4.2.1.10 | 0.00142 | - |
(1R,2S,4S,5R)-1,4,5-trihydroxy-2-(4-methoxybenzyl)-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HCl | Helicobacter pylori | |
4.2.1.10 | 0.0017 | - |
(1R,2R,4S,5R)-1,4,5-trihydroxy-3-oxo-2-propylcyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HOAc | Mycobacterium tuberculosis | |
4.2.1.10 | 0.00185 | - |
(1R,2S,4S,5R)-1,4,5-trihydroxy-3-oxo-2-(prop-2-en-1-yl)cyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HOAc | Mycobacterium tuberculosis | |
4.2.1.10 | 0.0026 | - |
(1R,2R,4S,5R)-2-[difluoro(pentafluorophenyl)methyl]-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HCl | Helicobacter pylori | |
4.2.1.10 | 0.0093 | - |
(1R,2R,4S,5R)-1,4,5-trihydroxy-3-oxo-2-(prop-2-en-1-yl)cyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HCl | Helicobacter pylori | |
4.2.1.10 | 0.02 | - |
(1R,2R,4S,5R)-1,4,5-trihydroxy-3-oxo-2-propylcyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HCl | Helicobacter pylori | |
4.2.1.10 | 0.0215 | - |
(1R,2S,4S,5R)-1,4,5-trihydroxy-3-oxo-2-(prop-2-en-1-yl)cyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HCl | Helicobacter pylori |