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Literature summary extracted from

  • Bräuer, L.; Brandt, W.; Schulze, D.; Zakharova, S.; Wessjohann, L.
    A structural model of the membrane-bound aromatic prenyltransferase UbiA from E. coli (2008), Chembiochem, 9, 982-992.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.39 expressed in Escherichia coli Escherichia coli

Protein Variants

EC Number Protein Variants Comment Organism
2.5.1.39 D191A mutant shows no 3-geranylgeranyl-4-hydroxybenzoate formation, mutant shows some residual hydrolysis activity Escherichia coli
2.5.1.39 D195A mutant shows no 3-geranylgeranyl-4-hydroxybenzoate formation, mutant shows some residual hydrolysis activity Escherichia coli
2.5.1.39 D71A mutant shows no 3-geranylgeranyl-4-hydroxybenzoate formation, mutant shows some residual hydrolysis activity Escherichia coli
2.5.1.39 D75A mutant shows no 3-geranylgeranyl-4-hydroxybenzoate formation, mutant shows some residual hydrolysis activity Escherichia coli
2.5.1.39 R137A mutant shows a strongly reduced formation of 3-geranylgeranyl-4-hydroxybenzoate, mutant shows some residual hydrolysis activity Escherichia coli

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.5.1.39 membrane
-
 Escherichia coli 16020
-

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.39 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.39 geranyl diphosphate + 4-hydroxybenzoate
-
 Escherichia coli 3-geranyl-4-hydroxybenzoate + diphosphate
-
 ?
2.5.1.39 additional information in the presence of Mg2+ the enzyme is also able to hydrolyze geranyl diphosphate without forming geranylgeranyl-4-hydroxybenzoate Escherichia coli ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.39 4-hydroxybenzoic acid oligoprenyltransferase
-
 Escherichia coli
2.5.1.39 ubiA
-
 Escherichia coli

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.5.1.39 37
-
 assay at Escherichia coli

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.5.1.39 7.8
-
 assay at Escherichia coli