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Literature summary extracted from

  • Meyer, M.R.; Maurer, H.H.
    Enantioselectivity in the methylation of the catecholic phase I metabolites of methylenedioxy designer drugs and their capability to inhibit catechol-O-methyltransferase-catalyzed dopamine 3-methylation (2009), Chem. Res. Toxicol., 22, 1205-1211.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.6 1,2-dihydroxy-4-[2-(methylamino)butyl]benzene uncompetitive inhibitor of the sCOMT isoform Homo sapiens
2.1.1.6 3,4-dihydroxymethamphetamine uncompetitive inhibitor of the sCOMT isoform Homo sapiens
2.1.1.6 N-ethyl-3,4-dihydroxyamphetamine uncompetitive inhibitor of the sCOMT isoform Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.6 0.02
-
 (R)-1,2-dihydroxy-4-[2-(methylamino)butyl]benzene isoform sCOMT, in phosphate buffer (pH 7.4) Homo sapiens
2.1.1.6 0.02
-
 (S)-1,2-dihydroxy-4-[2-(methylamino)butyl]benzene isoform sCOMT, in phosphate buffer (pH 7.4) Homo sapiens
2.1.1.6 0.03
-
 (R)-3,4-dihydroxymethamphetamine isoform sCOMT, in phosphate buffer (pH 7.4) Homo sapiens
2.1.1.6 0.03
-
 (S)-3,4-dihydroxymethamphetamine isoform sCOMT, in phosphate buffer (pH 7.4) Homo sapiens
2.1.1.6 0.07
-
 (S)-N-ethyl-3,4-dihydroxyamphetamine isoform sCOMT, in phosphate buffer (pH 7.4) Homo sapiens
2.1.1.6 0.09
-
 (R)-N-ethyl-3,4-dihydroxyamphetamine isoform sCOMT, in phosphate buffer (pH 7.4) Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.6 membrane isoform mbCOMT Homo sapiens 16020
-
2.1.1.6 microsome isoform mbCOMT Homo sapiens
-
-
2.1.1.6 soluble isoform sCOMT Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.6 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.6 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.6 (R)-1,2-dihydroxy-4-[2-(methylamino)butyl]benzene + S-adenosyl-L-methionine
-
 Homo sapiens ?
-
 ?
2.1.1.6 (R)-3,4-dihydroxymethamphetamine + S-adenosyl-L-methionine
-
 Homo sapiens ?
-
 ?
2.1.1.6 (R)-N-ethyl-3,4-dihydroxyamphetamine + S-adenosyl-L-methionine
-
 Homo sapiens ?
-
 ?
2.1.1.6 (S)-1,2-dihydroxy-4-[2-(methylamino)butyl]benzene + S-adenosyl-L-methionine
-
 Homo sapiens ?
-
 ?
2.1.1.6 (S)-3,4-dihydroxymethamphetamine + S-adenosyl-L-methionine
-
 Homo sapiens ?
-
 ?
2.1.1.6 (S)-N-ethyl-3,4-dihydroxyamphetamine + S-adenosyl-L-methionine
-
 Homo sapiens ?
-
 ?
2.1.1.6 3-hydroxytyramine + S-adenosyl-L-methionine
-
 Homo sapiens S-adenosyl-L-homocysteine + 3-methoxytyramine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.6 COMT
-
 Homo sapiens
2.1.1.6 SCOMT soluble isoform Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.1.1.6 0.1
-
 isoform sCOMT, in phosphate buffer (pH 7.4) Homo sapiens N-ethyl-3,4-dihydroxyamphetamine
2.1.1.6 0.2
-
 isoform sCOMT, in phosphate buffer (pH 7.4) Homo sapiens 3,4-dihydroxymethamphetamine
2.1.1.6 0.3
-
 isoform sCOMT, in phosphate buffer (pH 7.4) Homo sapiens 1,2-dihydroxy-4-[2-(methylamino)butyl]benzene