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Literature summary extracted from

  • Sousa, R.
    Tie me up, tie me down: inhibiting RNA polymerase (2008), Cell, 135, 205-207.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.7.7.6 drug development the enzyme is a target for drug design Thermus thermophilus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.6 myxopyronin produced by the bacteria Myxococcus fulvus, inhibits initiation of RNA polymerase transcription and binding complex structure. The compounds inhibits the enzyme also from rifamycin- or multidrug-resistant bacteria. the inhibition mechanism proceeds via inhibiting DNA binding rather than affecting transcription complex stability or processivity following DNA binding, overview Thermus thermophilus
2.7.7.6 rifamycin
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 Thermus thermophilus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.6 nucleus
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 Saccharomyces cerevisiae 5634
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.6 additional information Saccharomyces cerevisiae RNAPII recruits COMPASS, a histone methyltransferase, as well as the regulator Paf1C, to the transcription active site causing methylation of histone H3K4 in a transcription-dependent manner. The large RNAPII subunit Rpb1 attracts FACT, a transcription factor that FACT participates in regulation of DNA repair and replication, to the transcription site, and Rpb1 also interacts with RSC, an abundant Swi/Snf-like chromatin remodeling complex with multiple subunits, and other general transcription factors, as well as with histone chaperone proteins, mRNA processing and export factors, DNA repair factors, protein kinases, and other cellular proteins, overview ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.6 Saccharomyces cerevisiae
-
-
-
2.7.7.6 Thermus thermophilus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.6 additional information RNAPII recruits COMPASS, a histone methyltransferase, as well as the regulator Paf1C, to the transcription active site causing methylation of histone H3K4 in a transcription-dependent manner. The large RNAPII subunit Rpb1 attracts FACT, a transcription factor that FACT participates in regulation of DNA repair and replication, to the transcription site, and Rpb1 also interacts with RSC, an abundant Swi/Snf-like chromatin remodeling complex with multiple subunits, and other general transcription factors, as well as with histone chaperone proteins, mRNA processing and export factors, DNA repair factors, protein kinases, and other cellular proteins, overview Saccharomyces cerevisiae ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.7.6 More analysis of interaction sbetween the largest subunit Rpb1 and the other subunits, overview Saccharomyces cerevisiae

Synonyms

EC Number Synonyms Comment Organism
2.7.7.6 RNA polymerase
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 Thermus thermophilus
2.7.7.6 RNA polymerase II
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 Saccharomyces cerevisiae
2.7.7.6 RNAP
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 Thermus thermophilus
2.7.7.6 RNAPII
-
 Saccharomyces cerevisiae