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Literature summary extracted from
- Steroidogenic acute regulatory (StAR) protein and cholesterol side-chain cleavage (P450scc)-regulated steroidogenesis as an organ-specific molecular and cellular target for endocrine disrupting chemicals in fish (2008), Cell Biol. Toxicol., 24, 527-540.
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.15.6 | mitochondrial inner membrane | - |
Salmo salar | 5743 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.15.6 | Gadus morhua | - |
- |
- |
| 1.14.15.6 | Oncorhynchus mykiss | - |
- |
- |
| 1.14.15.6 | Salmo salar | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.15.6 | brain | - |
Salmo salar | - |
| 1.14.15.6 | gonad | - |
Salmo salar | - |
| 1.14.15.6 | interrenal cell | - |
Salmo salar | - |
| 1.14.15.6 | intestine | - |
Oncorhynchus mykiss | - |
| 1.14.15.6 | kidney | - |
Salmo salar | - |
| 1.14.15.6 | kidney | trunk | Oncorhynchus mykiss | - |
| 1.14.15.6 | liver | - |
Salmo salar | - |
| 1.14.15.6 | oocyte | - |
Gadus morhua | - |
| 1.14.15.6 | oocyte | follicular cell, oocyte membrane | Salmo salar | - |
| 1.14.15.6 | pyloric cecum | - |
Oncorhynchus mykiss | - |
| 1.14.15.6 | spleen | - |
Oncorhynchus mykiss | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.15.6 | cholesterol + reduced adrenodoxin + O2 | - |
Salmo salar | pregnenolone + 4-methylpentanal + oxidized adrenodoxin + H2O | - |
? |  |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.15.6 | cytochrome P450-mediated side-chain cleavage enzyme | - |
Oncorhynchus mykiss |
| 1.14.15.6 | cytochrome P450-mediated side-chain cleavage enzyme | - |
Gadus morhua |
| 1.14.15.6 | cytochrome P450-mediated side-chain cleavage enzyme | - |
Salmo salar |
| 1.14.15.6 | P450scc | - |
Oncorhynchus mykiss |
| 1.14.15.6 | P450scc | - |
Gadus morhua |
| 1.14.15.6 | P450scc | - |
Salmo salar |
Expression
| EC Number | Organism | Comment | Expression |
|---|---|---|---|
| 1.14.15.6 | Gadus morhua | 14 days exposure of previtellogenic ovarian oocytes to nonylphenol produces a unique and consistent concentration-specific pattern of modulation of StAR and P450scc gene expression, increasing from 0 (control) to 1 and 10 micromol, and decreasing at 50 and 100 micromol | up |
| 1.14.15.6 | Oncorhynchus mykiss | expression of StAR and P450scc transcripts in non-steroidogenic tissues | up |
| 1.14.15.6 | Salmo salar | relationship between cortisol production and induction of transcription of steroidogenic acute regulatory (StAR) protein and P450scc. Exposure of juveniles to 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene and the synthetic estrogen 17alpha-ethynylestradiol produces transcriptional modulations of StAR and P450scc expression in interrenal tissue. In juvenile salmon exposed to 17alpha-ethynylestradiol, expression of P450scc mRNA is detectable in the trunk kidney, while StAR mRNA is not quantifiable. 17alpha-ethynylestradiol produces time- and concentration-specific effects on the expression of the StAR, P450scc, P450arom isoforms and IGF-2 genes in gonadal tissues. In liver and kidney tissues exposed to the endocrine disrupting chemical 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene, significant induction of both StAR and P450scc mRNA | up |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.14.15.6 | metabolism | conversion of cholesterol to pregnenolone by P450scc represents the initiation of steroidogenesis | Salmo salar |
| 1.14.15.6 | physiological function | endocrine disrupting chemical modulation of acute steroid hormone regulation by targeting StAR and P450scc may have severe consequences for the entire reproduction process, including oocyte growth, development and overt fecundity | Gadus morhua |
| 1.14.15.6 | physiological function | expression of StAR and P450scc transcripts is related to steroid synthesis | Oncorhynchus mykiss |
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