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Literature summary extracted from

  • Mao, J.T.; Tashkin, D.P.; Tsu, I.H.; Serio, K.J.
    Differential modulation of leukotriene B4 synthesis and degradation in human bronchoalveolar lavage cells by lipopolysaccharide and tobacco smoke (2008), Cancer Prev. Res. (Phila), 1, 266-274.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.14.94 lipopolysaccharide upregulates expression and activity of LTB4OH in ex-smokers in a dose-dependent manner, but not in smokers. In vitro smoke exposure of ex-smokers' bronchoalveolar lavage cells abrogates the lipopolysaccharide-induced up-regulation of LTB4OH mRNA expression, thus tobacco smoke alters bronchoalveolar lavage cell LTB4OH mRNA expression in response to lipopolysaccharide exposure Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.94 17-octadecynoic acid
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.94 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.94 bronchoalveolar lavage ex-smokers express significantly higher LTB4OH mRNA levels than smokers Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.94 leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 20-hydroxy-leukotriene B4 + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.94 LTB4 omega-hydroxylase
-
 Homo sapiens
1.14.14.94 LTB4OH
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.14.14.94 physiological function by regulating the balance of leukotriene B4 in the lung, LTB4OH may function as a suppressor of lung carcinogenesis Homo sapiens