Literature summary extracted from

Showalter, S.L.; Showalter, T.N.; Witkiewicz, A.; Havens, R.; Kennedy, E.P.; Hucl, T.; Kern, S.E.; Yeo, C.J.; Brody, J.R.
Evaluating the drug-target relationship between thymidylate synthase expression and tumor response to 5-fluorouracil. Is it time to move forward? (2008), Cancer Biol. Ther., 7, 986-994.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.1.1.45	5-fluoropyrimidine-2,4(1H,3H)-dione	-	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.1.1.45	Homo sapiens	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.1.1.45	5,10-methylenetetrahydrofolate + dUMP	-	Homo sapiens	dihydrofolate + dTMP	-	?

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
2.1.1.45	N5,N10-methylenetetrahydrofolate	-	Homo sapiens

Expression

EC Number	Organism	Comment	Expression
2.1.1.45	Homo sapiens	there is an approximately 2fold inverse relationship between thymidylate synthase expression and response to 5-fluoruracil	down

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Release 2023.1 (January 2023)