BRENDA - Enzyme Database show

Microsomal prostaglandin E synthase-1 and cyclooxygenase-2 are both required for ischaemic excitotoxicity

Ikeda-Matsuo, Y.; Hirayama, Y.; Ota, A.; Uematsu, S.; Akira, S.; Sasaki, Y.; Br. J. Pharmacol. 159, 1174-1186 (2010)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.3
MK-886
glutamate-induced PGE2 production is suppressed almost completely by MK-886 at a concentration of 0.003 mM or higher
Mus musculus
5.3.99.3
MK-886
glutamate-induced PGE2 production is suppressed almost completely by MK-886 at a concentration of 0.003 mM or higher
Rattus norvegicus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
5.3.99.3
microsome
-
Mus musculus
-
-
5.3.99.3
microsome
-
Rattus norvegicus
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.3
Mus musculus
-
-
-
5.3.99.3
Rattus norvegicus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.3
hippocampus
-
Mus musculus
-
5.3.99.3
hippocampus
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.3
Prostaglandin H2
-
702949
Mus musculus
Prostaglandin E2
-
-
-
?
5.3.99.3
Prostaglandin H2
-
702949
Rattus norvegicus
Prostaglandin E2
-
-
-
?
IC50 Value
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
5.3.99.3
0.0024
-
-
Mus musculus
MK-886
5.3.99.3
0.0024
-
-
Rattus norvegicus
MK-886
IC50 Value (protein specific)
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
5.3.99.3
0.0024
-
-
Mus musculus
MK-886
5.3.99.3
0.0024
-
-
Rattus norvegicus
MK-886
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.3
MK-886
glutamate-induced PGE2 production is suppressed almost completely by MK-886 at a concentration of 0.003 mM or higher
Mus musculus
5.3.99.3
MK-886
glutamate-induced PGE2 production is suppressed almost completely by MK-886 at a concentration of 0.003 mM or higher
Rattus norvegicus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
5.3.99.3
microsome
-
Mus musculus
-
-
5.3.99.3
microsome
-
Rattus norvegicus
-
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.3
hippocampus
-
Mus musculus
-
5.3.99.3
hippocampus
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.3
Prostaglandin H2
-
702949
Mus musculus
Prostaglandin E2
-
-
-
?
5.3.99.3
Prostaglandin H2
-
702949
Rattus norvegicus
Prostaglandin E2
-
-
-
?
Expression
EC Number
Organism
Commentary
Expression
5.3.99.3
Mus musculus
1 mM glutamate up-regulates the expression of mPGES-1 to about 3fold that in the controls
up
5.3.99.3
Rattus norvegicus
1 mM glutamate up-regulates the expression of mPGES-1 to about 3fold that in the controls
up
General Information
EC Number
General Information
Commentary
Organism
5.3.99.3
physiological function
microsomal prostaglandin E synthase-1 and cyclooxygenase-2 are co-induced by excess glutamate in ischaemic brain. mPGES-1 activity is required for cyclooxygenase-2 to cause neuronal damage in ischaemic injury
Mus musculus
5.3.99.3
physiological function
microsomal prostaglandin E synthase-1 and cyclooxygenase-2 are co-induced by excess glutamate in ischaemic brain. mPGES-1 activity is required for cyclooxygenase-2 to cause neuronal damage in ischaemic injury
Rattus norvegicus
General Information (protein specific)
EC Number
General Information
Commentary
Organism
5.3.99.3
physiological function
microsomal prostaglandin E synthase-1 and cyclooxygenase-2 are co-induced by excess glutamate in ischaemic brain. mPGES-1 activity is required for cyclooxygenase-2 to cause neuronal damage in ischaemic injury
Mus musculus
5.3.99.3
physiological function
microsomal prostaglandin E synthase-1 and cyclooxygenase-2 are co-induced by excess glutamate in ischaemic brain. mPGES-1 activity is required for cyclooxygenase-2 to cause neuronal damage in ischaemic injury
Rattus norvegicus
Expression (protein specific)
EC Number
Organism
Commentary
Expression
5.3.99.3
Mus musculus
1 mM glutamate up-regulates the expression of mPGES-1 to about 3fold that in the controls
up
5.3.99.3
Rattus norvegicus
1 mM glutamate up-regulates the expression of mPGES-1 to about 3fold that in the controls
up