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Literature summary extracted from

  • Firestine, S.; Wu, W.; Youn, H.; Jo Davisson, V.
    Interrogating the mechanism of a tight binding inhibitor of AIR carboxylase (2009), Bioorg. Med. Chem., 17, 794-803.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.21 3-nitro-1-(beta-D-ribofuranosyl)pyrrole 5'-phosphate
-
 Gallus gallus
4.1.1.21 4-nitro-1-(-beta-D-ribofuranosyl)pyrazole 5'-phosphate
-
 Gallus gallus
4.1.1.21 4-nitro-1-(beta-D-ribofuranosyl)imidazole 5'-phosphate
-
 Gallus gallus
4.1.1.21 4-Nitro-5-aminoimidazole ribonucleotide slow, tight binding inhibitor Gallus gallus
4.1.1.21 5-amino-1-(beta-D-ribofuranosyl)-1,2,3-triazole-4-carboxylate 5'-phosphate
-
 Gallus gallus
4.1.1.21 5-amino-1-(beta-D-ribofuranosyl)-4-nitropyrazole 5'-phosphate
-
 Gallus gallus
4.1.1.21 5-amino-1-(beta-D-ribofuranosyl)imidazole-4-carboxaldehyde 5'-phosphate
-
 Gallus gallus
4.1.1.21 5-amino-1-(beta-D-ribofuranosyl)pyrazole-4-carboxylate 5'-phosphate
-
 Gallus gallus

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.21 Gallus gallus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.21 1-(5-Phosphoribosyl)-5-aminoimidazole + CO2
-
 Gallus gallus 1-(5-Phosphoribosyl)-5-amino-4-imidazolecarboxylate
-
 ?
4.1.1.21 additional information AIR carboxylase cannot use N5-carboxyaminoimidazole ribonucleotide, 5-amino-1-(beta-D-ribofuranosyl)pyrazole-4-carboxylate 5'-phosphate, and 5-amino-1-(beta-D-ribofuranosyl)-1,2,3-triazole-4-carboxylate 5'-phosphate as substrates Gallus gallus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.21 AIR carboxylase
-
 Gallus gallus
4.1.1.21 aminoimidazole ribonucleotide carboxylase
-
 Gallus gallus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.1.1.21 0.00000034
-
 4-Nitro-5-aminoimidazole ribonucleotide in 50 mM Tris-HCl, 0.5 mM EDTA, pH 8.0 Gallus gallus
4.1.1.21 0.00039
-
 5-amino-1-(beta-D-ribofuranosyl)-4-nitropyrazole 5'-phosphate in 50 mM Tris-HCl, 0.5 mM EDTA, pH 8.0 Gallus gallus
4.1.1.21 0.0013
-
 4-nitro-1-(beta-D-ribofuranosyl)imidazole 5'-phosphate in 50 mM Tris-HCl, 0.5 mM EDTA, pH 8.0 Gallus gallus
4.1.1.21 0.0028
-
 5-amino-1-(beta-D-ribofuranosyl)-1,2,3-triazole-4-carboxylate 5'-phosphate in 50 mM Tris-HCl, 0.5 mM EDTA, pH 8.0 Gallus gallus
4.1.1.21 0.006
-
 5-amino-1-(beta-D-ribofuranosyl)pyrazole-4-carboxylate 5'-phosphate in 50 mM Tris-HCl, 0.5 mM EDTA, pH 8.0 Gallus gallus
4.1.1.21 0.022
-
 4-nitro-1-(-beta-D-ribofuranosyl)pyrazole 5'-phosphate in 50 mM Tris-HCl, 0.5 mM EDTA, pH 8.0 Gallus gallus
4.1.1.21 0.062
-
 5-amino-1-(beta-D-ribofuranosyl)imidazole-4-carboxaldehyde 5'-phosphate in 50 mM Tris-HCl, 0.5 mM EDTA, pH 8.0 Gallus gallus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
4.1.1.21 0.1
-
 IC50 above 0.1 mM Gallus gallus 3-nitro-1-(beta-D-ribofuranosyl)pyrrole 5'-phosphate