BRENDA - Enzyme Database show

On the mechanism of microsomal prostaglandin E synthase type-2--a theoretical study of endoperoxide reaction with MeS-

Li, Y.; Angelastro, M.; Shimshock, S.; Reiling, S.; Vaz, R.J.; Bioorg. Med. Chem. Lett. 20, 338-340 (2010)

Data extracted from this reference:

Engineering
EC Number
Amino acid exchange
Commentary
Organism
5.3.99.3
R126A
the mutation of the enzyme abolishes its PGES activity to exhibit a novel glutathione-dependent reductase activity
Homo sapiens
5.3.99.3
R126Q
the mutation of the enzyme abolishes its PGES activity to exhibit a novel glutathione-dependent reductase activity
Homo sapiens
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
5.3.99.3
microsome
-
Homo sapiens
-
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.3
Prostaglandin H2
Homo sapiens
-
Prostaglandin E2
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.3
Homo sapiens
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.3
Prostaglandin H2
-
702622
Homo sapiens
Prostaglandin E2
-
-
-
?
Engineering (protein specific)
EC Number
Amino acid exchange
Commentary
Organism
5.3.99.3
R126A
the mutation of the enzyme abolishes its PGES activity to exhibit a novel glutathione-dependent reductase activity
Homo sapiens
5.3.99.3
R126Q
the mutation of the enzyme abolishes its PGES activity to exhibit a novel glutathione-dependent reductase activity
Homo sapiens
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
5.3.99.3
microsome
-
Homo sapiens
-
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.3
Prostaglandin H2
Homo sapiens
-
Prostaglandin E2
-
-
?
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.3
Prostaglandin H2
-
702622
Homo sapiens
Prostaglandin E2
-
-
-
?