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Literature summary extracted from

  • Innocenti, A.; Leewattanapasuk, W.; Manole, G.; Scozzafava, A.; Muehlschlegel, F.A.; Supuran, C.T.
    Carbonic anhydrase activators: Activation of the beta-carbonic anhydrase from the pathogenic yeast Candida glabrata with amines and amino acids (2010), Bioorg. Med. Chem. Lett., 20, 1701-1704.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.2.1.1 1-(2-aminoethyl)-piperazine activation constant of 0.0149 mM [Candida] glabrata
4.2.1.1 2-(2-aminoethyl)pyridine activation constant of 0.0163 mM [Candida] glabrata
4.2.1.1 2-pyridyl-methylamine activation constant of 0.015 mM [Candida] glabrata
4.2.1.1 4-(2-aminoethyl)-morpholine activation constant of 0.0101 mM [Candida] glabrata
4.2.1.1 4-amino-L-phenylalanine activation constant of 0.0316 mM [Candida] glabrata
4.2.1.1 D-Dopa activation constant of 0.0151 mM [Candida] glabrata
4.2.1.1 D-His activation constant of 0.0212 mM [Candida] glabrata
4.2.1.1 D-Phe activation constant of 0.0157 mM [Candida] glabrata
4.2.1.1 D-Trp activation constant of 0.0121 mM [Candida] glabrata
4.2.1.1 D-Tyr best activator, activation constant of 0.0071 mM [Candida] glabrata
4.2.1.1 dopamine activation constant of 0.0276 mM [Candida] glabrata
4.2.1.1 histamine activation constant of 0.0274 mM [Candida] glabrata
4.2.1.1 L-adrenaline activation constant of 0.0108 mM [Candida] glabrata
4.2.1.1 L-Dopa activation constant of 0.0233 mM [Candida] glabrata
4.2.1.1 L-His activation constant of 0.037 mM [Candida] glabrata
4.2.1.1 L-Phe activation constant of 0.0241 mM [Candida] glabrata
4.2.1.1 L-Trp activation constant of 0.0228 mM [Candida] glabrata
4.2.1.1 L-Tyr best activator, activation constant of 0.0095 mM [Candida] glabrata
4.2.1.1 serotonin activation constant of 0.0167 mM [Candida] glabrata

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.2.1.1 7.9
-
 histamine at 25°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 [Candida] glabrata

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.1 [Candida] glabrata
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.1 CO2 + H2O
-
 [Candida] glabrata H2CO3
-
 r

Synonyms

EC Number Synonyms Comment Organism
4.2.1.1 beta-carbonic anhydrase
-
 [Candida] glabrata

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.2.1.1 380000
-
 histamine at 25°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 [Candida] glabrata
4.2.1.1 1070000
-
 histamine at 25°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4, in the presence of 0.01 mM histamine [Candida] glabrata