EC Number | Application | Comment | Organism |
---|---|---|---|
1.11.1.23 | medicine | fosfomycin is a clinically utilized antibiotic of low toxicity, blocking bacterial cell wall biosynthesis by acting as an analogue of phosphoenolpyruvate | Streptomyces fradiae |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.11.1.23 | (S)-2-hydroxypropylphosphonic acid + 2 NADH + O2 | Streptomyces fradiae | - |
cis-(1R,2S)-epoxypropylphosphonic acid + 2 H2O + 2 NAD+ | i.e. fosfomycin | ? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.11.1.23 | Streptomyces fradiae | D2SNF6 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.11.1.23 | (S)-2-hydroxybutylphosphonic acid + 2 NADH + O2 | - |
Streptomyces fradiae | cis-(1R,2S)-epoxybutylphosphonic acid + 2 H2O + 2 NAD+ | - |
? | |
1.11.1.23 | (S)-2-hydroxypropylphosphonic acid + 2 NADH + O2 | - |
Streptomyces fradiae | cis-(1R,2S)-epoxypropylphosphonic acid + 2 H2O + 2 NAD+ | i.e. fosfomycin | ? | |
1.11.1.23 | additional information | no activity with 2-hydroxyethyl phosphonic acid | Streptomyces fradiae | ? | - |
? |