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Literature summary extracted from

  • Jarmula, A.; Dowiercial, A.; Rode, W.
    A molecular modeling study of the interaction of 2-fluoro-substituted analogues of dUMP/FdUMP with thymidylate synthase (2008), Bioorg. Med. Chem. Lett., 18, 2701-2708.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.45 2',5-difluoro-ara-UMP slow-binding (time-dependent) inhibitor Escherichia coli
2.1.1.45 2'-deoxy-2',2'-difluorouridine 5'-dihydrogen classic inhibitor (no time dependence of inhibition observed) Escherichia coli
2.1.1.45 2'-fluoro-ara-UMP classic inhibitor (no time dependence of inhibition observed) Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.45 Escherichia coli P0A884
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP
-
 Escherichia coli dihydrofolate + dTMP
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.45 N5,N10-methylenetetrahydrofolate
-
 Escherichia coli

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.1.45 0.00477
-
 2',5-difluoro-ara-UMP
-
 Escherichia coli
2.1.1.45 0.0103
-
 2'-fluoro-ara-UMP
-
 Escherichia coli
2.1.1.45 0.4328
-
 2'-deoxy-2',2'-difluorouridine 5'-dihydrogen
-
 Escherichia coli