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The role of prostacyclin synthase and thromboxane synthase signaling in the development and progression of cancer

Cathcart, M.C.; Reynolds, J.V.; OByrne, K.J.; Pidgeon, G.P.; Biochim. Biophys. Acta 1805, 153-166 (2010)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
5.3.99.4
interleukin-1
-
Homo sapiens
5.3.99.4
interleukin-6
-
Homo sapiens
5.3.99.4
TNFalpha
-
Homo sapiens
Application
EC Number
Application
Commentary
Organism
5.3.99.4
medicine
prostacyclin synthase may be chemopreventive in cancer
Homo sapiens
Cloned(Commentary)
EC Number
Commentary
Organism
5.3.99.4
-
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.4
rofecoxib
-
Homo sapiens
5.3.99.5
ozagrel
-
Homo sapiens
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
5.3.99.4
endoplasmic reticulum
-
Homo sapiens
5783
-
5.3.99.4
nuclear membrane
-
Homo sapiens
31965
-
5.3.99.4
plasma membrane
-
Homo sapiens
5886
-
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
5.3.99.4
52000
-
-
Homo sapiens
5.3.99.5
60000
-
SDS-PAGE
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.4
Prostaglandin H2
Homo sapiens
-
Prostaglandin I2
-
-
?
5.3.99.5
prostaglandin H2
Homo sapiens
-
thromboxane A2 + ?
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.4
Homo sapiens
-
-
-
5.3.99.5
Homo sapiens
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
5.3.99.4
-
Homo sapiens
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.4
lung cancer cell
-
Homo sapiens
-
5.3.99.4
myometrial cell
-
Homo sapiens
-
5.3.99.4
neuron
-
Homo sapiens
-
5.3.99.4
smooth muscle cell
-
Homo sapiens
-
5.3.99.4
umbilical vein endothelial cell
-
Homo sapiens
-
5.3.99.4
vascular endothelial cell
-
Homo sapiens
-
5.3.99.5
A-549 cell
-
Homo sapiens
-
5.3.99.5
breast carcinoma cell
-
Homo sapiens
-
5.3.99.5
colorectal cancer cell
-
Homo sapiens
-
5.3.99.5
lung
in normal lung tissue, TXS is moderately expressed in bronchial epithelial cells and weakly expressed in vascular smooth muscle cells
Homo sapiens
-
5.3.99.5
lung cancer cell
-
Homo sapiens
-
5.3.99.5
non-small cell lung cancer cell
-
Homo sapiens
-
5.3.99.5
papillary thyroid carcinoma cell
-
Homo sapiens
-
5.3.99.5
prostate cancer cell
-
Homo sapiens
-
5.3.99.5
renal carcinoma cell
-
Homo sapiens
-
5.3.99.5
urinary bladder cancer cell
-
Homo sapiens
-
5.3.99.5
uterine cancer cell
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.4
Prostaglandin H2
-
702474
Homo sapiens
Prostaglandin I2
-
-
-
?
5.3.99.5
prostaglandin H2
-
702474
Homo sapiens
thromboxane A2 + ?
-
-
-
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
5.3.99.5
heme
-
Homo sapiens
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
5.3.99.4
interleukin-1
-
Homo sapiens
5.3.99.4
interleukin-6
-
Homo sapiens
5.3.99.4
TNFalpha
-
Homo sapiens
Application (protein specific)
EC Number
Application
Commentary
Organism
5.3.99.4
medicine
prostacyclin synthase may be chemopreventive in cancer
Homo sapiens
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
5.3.99.4
-
Homo sapiens
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
5.3.99.5
heme
-
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.4
rofecoxib
-
Homo sapiens
5.3.99.5
ozagrel
-
Homo sapiens
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
5.3.99.4
endoplasmic reticulum
-
Homo sapiens
5783
-
5.3.99.4
nuclear membrane
-
Homo sapiens
31965
-
5.3.99.4
plasma membrane
-
Homo sapiens
5886
-
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
5.3.99.4
52000
-
-
Homo sapiens
5.3.99.5
60000
-
SDS-PAGE
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.4
Prostaglandin H2
Homo sapiens
-
Prostaglandin I2
-
-
?
5.3.99.5
prostaglandin H2
Homo sapiens
-
thromboxane A2 + ?
-
-
?
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
5.3.99.4
-
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.4
lung cancer cell
-
Homo sapiens
-
5.3.99.4
myometrial cell
-
Homo sapiens
-
5.3.99.4
neuron
-
Homo sapiens
-
5.3.99.4
smooth muscle cell
-
Homo sapiens
-
5.3.99.4
umbilical vein endothelial cell
-
Homo sapiens
-
5.3.99.4
vascular endothelial cell
-
Homo sapiens
-
5.3.99.5
A-549 cell
-
Homo sapiens
-
5.3.99.5
breast carcinoma cell
-
Homo sapiens
-
5.3.99.5
colorectal cancer cell
-
Homo sapiens
-
5.3.99.5
lung
in normal lung tissue, TXS is moderately expressed in bronchial epithelial cells and weakly expressed in vascular smooth muscle cells
Homo sapiens
-
5.3.99.5
lung cancer cell
-
Homo sapiens
-
5.3.99.5
non-small cell lung cancer cell
-
Homo sapiens
-
5.3.99.5
papillary thyroid carcinoma cell
-
Homo sapiens
-
5.3.99.5
prostate cancer cell
-
Homo sapiens
-
5.3.99.5
renal carcinoma cell
-
Homo sapiens
-
5.3.99.5
urinary bladder cancer cell
-
Homo sapiens
-
5.3.99.5
uterine cancer cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.4
Prostaglandin H2
-
702474
Homo sapiens
Prostaglandin I2
-
-
-
?
5.3.99.5
prostaglandin H2
-
702474
Homo sapiens
thromboxane A2 + ?
-
-
-
?
Expression
EC Number
Organism
Commentary
Expression
5.3.99.4
Homo sapiens
a dramatic loss in PGIS mRNA levels is observed in primary lung tumor samples
down
5.3.99.4
Homo sapiens
PGIS mRNA and protein expression is increased in response to mechanical cyclical stretch in both spinal ligament and uterine myometrial cells, up-regulation is observed in umbilical vein endothelial cell treated with a thromboxane analogue
up
5.3.99.5
Homo sapiens
an overall increase in TXS expression is observed in tumor tissues relative to normal, increased TXS expression at mRNA level is reported in renal cell carcinoma, breast carcinoma, prostate cancer and uterine cancer when compared with matched normal tissues
up
Expression (protein specific)
EC Number
Organism
Commentary
Expression
5.3.99.4
Homo sapiens
a dramatic loss in PGIS mRNA levels is observed in primary lung tumor samples
down
5.3.99.4
Homo sapiens
PGIS mRNA and protein expression is increased in response to mechanical cyclical stretch in both spinal ligament and uterine myometrial cells, up-regulation is observed in umbilical vein endothelial cell treated with a thromboxane analogue
up
5.3.99.5
Homo sapiens
an overall increase in TXS expression is observed in tumor tissues relative to normal, increased TXS expression at mRNA level is reported in renal cell carcinoma, breast carcinoma, prostate cancer and uterine cancer when compared with matched normal tissues
up