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Literature summary extracted from

  • Cathcart, M.C.; Reynolds, J.V.; OByrne, K.J.; Pidgeon, G.P.
    The role of prostacyclin synthase and thromboxane synthase signaling in the development and progression of cancer (2010), Biochim. Biophys. Acta, 1805, 153-166.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
5.3.99.4 interleukin-1
-
 Homo sapiens
5.3.99.4 interleukin-6
-
 Homo sapiens
5.3.99.4 TNFalpha
-
 Homo sapiens

Application

EC Number Application Comment Organism
5.3.99.4 medicine prostacyclin synthase may be chemopreventive in cancer Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.3.99.4
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.3.99.4 rofecoxib
-
 Homo sapiens
5.3.99.5 ozagrel
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.3.99.4 endoplasmic reticulum
-
 Homo sapiens 5783
-
5.3.99.4 nuclear membrane
-
 Homo sapiens 31965
-
5.3.99.4 plasma membrane
-
 Homo sapiens 5886
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.3.99.4 52000
-
-
 Homo sapiens
5.3.99.5 60000
-
 SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.99.4 Prostaglandin H2 Homo sapiens
-
 Prostaglandin I2
-
 ?
5.3.99.5 prostaglandin H2 Homo sapiens
-
 thromboxane A2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.4 Homo sapiens
-
-
-
5.3.99.5 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.3.99.4
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.99.4 lung cancer cell
-
 Homo sapiens
-
5.3.99.4 myometrial cell
-
 Homo sapiens
-
5.3.99.4 neuron
-
 Homo sapiens
-
5.3.99.4 smooth muscle cell
-
 Homo sapiens
-
5.3.99.4 umbilical vein endothelial cell
-
 Homo sapiens
-
5.3.99.4 vascular endothelial cell
-
 Homo sapiens
-
5.3.99.5 A-549 cell
-
 Homo sapiens
-
5.3.99.5 breast carcinoma cell
-
 Homo sapiens
-
5.3.99.5 colorectal cancer cell
-
 Homo sapiens
-
5.3.99.5 lung in normal lung tissue, TXS is moderately expressed in bronchial epithelial cells and weakly expressed in vascular smooth muscle cells Homo sapiens
-
5.3.99.5 lung cancer cell
-
 Homo sapiens
-
5.3.99.5 non-small cell lung cancer cell
-
 Homo sapiens
-
5.3.99.5 papillary thyroid carcinoma cell
-
 Homo sapiens
-
5.3.99.5 prostate cancer cell
-
 Homo sapiens
-
5.3.99.5 renal carcinoma cell
-
 Homo sapiens
-
5.3.99.5 urinary bladder cancer cell
-
 Homo sapiens
-
5.3.99.5 uterine cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.4 Prostaglandin H2
-
 Homo sapiens Prostaglandin I2
-
 ?
5.3.99.5 prostaglandin H2
-
 Homo sapiens thromboxane A2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.3.99.4 prostacyclin synthase
-
 Homo sapiens
5.3.99.5 thromboxane A2 synthase
-
 Homo sapiens
5.3.99.5 TXS
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
5.3.99.5 heme
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
5.3.99.4 Homo sapiens a dramatic loss in PGIS mRNA levels is observed in primary lung tumor samples down
5.3.99.4 Homo sapiens PGIS mRNA and protein expression is increased in response to mechanical cyclical stretch in both spinal ligament and uterine myometrial cells, up-regulation is observed in umbilical vein endothelial cell treated with a thromboxane analogue up
5.3.99.5 Homo sapiens an overall increase in TXS expression is observed in tumor tissues relative to normal, increased TXS expression at mRNA level is reported in renal cell carcinoma, breast carcinoma, prostate cancer and uterine cancer when compared with matched normal tissues up