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Literature summary extracted from

  • Pettersson, H.; Lundqvist, J.; Oliw, E.; Norlin, M.
    CYP7B1-mediated metabolism of 5alpha-androstane-3alpha,17beta-diol (3alpha-Adiol): A novel pathway for potential regulation of the cellular levels of androgens and neurosteroids (2009), Biochim. Biophys. Acta, 1791, 1206-1215.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.29 from pCMV6 vector overexpressed in HEK-293 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.29 5alpha-androstane-3alpha,17beta-diol inhibition of the reaction with dehydroepiandrosterone Homo sapiens
1.14.14.29 5alpha-androstane-3alpha,17beta-diol inhibition of the reaction with dehydroepiandrosterone; significantly inhibits CYP7B1-mediated 7alpha-hydroxylation Sus scrofa
1.14.14.29 additional information testosterone, dehydroepiandrosterone-sulfate or 22-hydroxycholesterol have little or no effects on CYP7B1-mediated activities Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.29 microsome
-
 Sus scrofa
-
-
1.14.14.29 microsome
-
 Mus musculus
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.29 Homo sapiens
-
-
-
1.14.14.29 Homo sapiens O75881
-
-
1.14.14.29 Mus musculus Q60991
-
-
1.14.14.29 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.29 HEK-293 cell
-
 Homo sapiens
-
1.14.14.29 liver
-
 Sus scrofa
-
1.14.14.29 liver
-
 Mus musculus
-
1.14.14.29 SH-SY5Y cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.29 5alpha-androstane-3alpha,17beta-diol + NADPH + O2
-
 Homo sapiens 5alpha-androstane-3alpha,7alpha,17beta-triol + NADP+ + H2O major product, plus some hydroxylation at position 6 ?
1.14.14.29 5alpha-androstane-3alpha,17beta-diol + NADPH + O2
-
 Sus scrofa 5alpha-androstane-3alpha,7alpha,17beta-triol + NADP+ + H2O major product, plus some hydroxylation at position 6 ?
1.14.14.29 5alpha-androstane-3alpha,17beta-diol + NADPH + O2
-
 Sus scrofa ? + NADP+ + H2O
-
 ?
1.14.14.29 5alpha-androstane-3alpha,17beta-diol + NADPH + O2
-
 Homo sapiens ? + NADP+ + H2O
-
 ?
1.14.14.29 5alpha-androstane-3alpha,17beta-diol + NADPH + O2
-
 Mus musculus ? + NADP+ + H2O
-
 ?
1.14.14.29 dehydroepiandrosterone + NADPH + H+ + o2
-
 Mus musculus 7alpha-hydroxy-dehydroepiandrosterone + NADP+ + H2O
-
 ?
1.14.14.29 dehydroepiandrosterone + NADPH + H+ + O2
-
 Homo sapiens ? + NADP+ + H2O
-
 ?
1.14.14.29 dehydroepiandrosterone + NADPH + H+ + O2
-
 Sus scrofa ? + NADP+ + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.29 CYP7B1
-
 Homo sapiens
1.14.14.29 CYP7B1
-
 Sus scrofa
1.14.14.29 CYP7B1
-
 Mus musculus
1.14.14.29 Steroid hydroxylase
-
 Sus scrofa
1.14.14.29 Steroid hydroxylase
-
 Homo sapiens
1.14.14.29 Steroid hydroxylase
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.29 NADPH
-
 Sus scrofa
1.14.14.29 NADPH
-
 Homo sapiens
1.14.14.29 NADPH
-
 Mus musculus

General Information

EC Number General Information Comment Organism
1.14.14.29 physiological function activity towards 5alpha-androstane-3alpha,17beta-diol is very low or undetectable in livers of Cyp7b1(-/-) knockout mice. CYP7B1-mediated catalysis may play a role for control of the cellular levels of androgens, not only of estrogens Mus musculus
1.14.14.29 physiological function CYP7B1-mediated catalysis may play a role for control of the cellular levels of androgens, not only of estrogens Sus scrofa
1.14.14.29 physiological function CYP7B1-mediated catalysis may play a role for control of the cellular levels of androgens, not only of estrogens Homo sapiens