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Literature summary extracted from

  • Jones, M.K.; Catte, A.; Li, L.; Segrest, J.P.
    Dynamics of activation of lecithin:cholesterol acyltransferase by apolipoprotein A-I (2009), Biochemistry, 48, 11196-11210.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.43 apolipoprotein A-I the central helix 4-helix 5-helix 6 domain in apoA-I is the unique structural element that provides full specificity to apoA-I activation of LCAT through substantially more LCAT binding and substrate binding and presentation to LCAT thorough the presentation tunnel, molecular dynamics, role of apoA-I in activation of LCAT involved simulations of discoidal particles, overview Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.43 additional information LCAT shows product inhibition Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.43 extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.43 phosphatidylcholine + cholesterol Homo sapiens
-
 cholesteryl ester + lysophosphatidylcholine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.43 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.43 blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.43 additional information cholesteryl ester-rich HDL particles bind LCAT effectively and contain apolipoprotein A-I and ample phosphatidylcholine and unesterified cholesterol substrates but exhibit relatively low reactivity with LCAT since the cholesteryl ester products cannot be removed from the active site Homo sapiens ?
-
 ?
2.3.1.43 phosphatidylcholine + cholesterol
-
 Homo sapiens cholesteryl ester + lysophosphatidylcholine
-
 ?
2.3.1.43 phosphatidylcholine + cholesterol enzyme with bound activator apolipoprotein A-I, structure-function relationship and analysis, molecular dynamics and simulations, overview Homo sapiens cholesteryl ester + lysophosphatidylcholine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.43 LCAT
-
 Homo sapiens
2.3.1.43 lecithin:cholesterol acyltransferase
-
 Homo sapiens