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Literature summary extracted from

  • Upadhyay, A.K.; Borbat, P.P.; Wang, J.; Freed, J.H.; Edmondson, D.E.
    Determination of the oligomeric states of human and rat monoamine oxidases in the outer mitochondrial membrane and octyl beta-D-glucopyranoside micelles using pulsed dipolar electron spin resonance spectroscopy (2008), Biochemistry, 47, 1554-1566.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.4.3.4 expression of MAOA in Pichia pastoris KM71 cell mitochondria Rattus norvegicus
1.4.3.4 expression of MAOB in Pichia pastoris KM71 cell mitochondria Rattus norvegicus
1.4.3.4 expression of wild-type and mutant MAOA in Pichia pastoris KM71 cell mitochondria Homo sapiens
1.4.3.4 expression of wild-type and mutant MAOB in Pichia pastoris KM71 cell mitochondria Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.4.3.4 E142K a MAOB mutant Homo sapiens
1.4.3.4 K151E a MAOA mutant Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.4 Clorgyline
-
 Homo sapiens
1.4.3.4 Clorgyline
-
 Rattus norvegicus
1.4.3.4 Pargyline
-
 Homo sapiens
1.4.3.4 Pargyline
-
 Rattus norvegicus
1.4.3.4 ParSL a pargyline based nitroxide spin labeled irreversible inhibitor, active site binding, structure, overview; a pargyline based nitroxide spin labeled irreversible inhibitor, active site binding, structure, overview Homo sapiens
1.4.3.4 ParSL a pargyline based nitroxide spin labeled irreversible inhibitor, active site binding, structure, overview; a pargyline based nitroxide spin labeled irreversible inhibitor, active site binding, structure, overview Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.4.3.4 mitochondrial outer membrane
-
 Homo sapiens 5741
-
1.4.3.4 mitochondrial outer membrane
-
 Rattus norvegicus 5741
-

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.4 Homo sapiens P21397 MAOA
-
1.4.3.4 Homo sapiens P27338 MAOB
-
1.4.3.4 Rattus norvegicus P19643 MAOB
-
1.4.3.4 Rattus norvegicus P21396 MAOA
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.4.3.4 flavoprotein
-
 Homo sapiens
1.4.3.4 flavoprotein
-
 Rattus norvegicus

Purification (Commentary)

EC Number Purification (Comment) Organism
1.4.3.4 recombinant wild-type and mutant MAOA from Pichia pastoris KM71 cell mitochondria partially as mitochondrial outer membrane-bound proteins Homo sapiens
1.4.3.4 recombinant wild-type and mutant MAOB from Pichia pastoris KM71 cell mitochondria partially as mitochondrial outer membrane-bound proteins Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.4 additional information active site structure, overview Homo sapiens ?
-
 ?
1.4.3.4 additional information active site structure, overview Rattus norvegicus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.4.3.4 dimer MAOB exists entirely as dimer Homo sapiens
1.4.3.4 dimer MAOB exists entirely as dimer Rattus norvegicus
1.4.3.4 monomer or dimer MAOA is partly dimeric in the mitochondrial outer membrane and in octyl beta-D-glucopyranoside micelles Homo sapiens
1.4.3.4 monomer or dimer MAOA is partly dimeric in the mitochondrial outer membrane and in octyl beta-D-glucopyranoside micelles Rattus norvegicus
1.4.3.4 More no role of the Glu-X-Lys motif in stabilizing dimeric structures of MAOs, three-dimensional structure analysis of MAOA, overview Homo sapiens
1.4.3.4 More no role of the Glu-X-Lys motif in stabilizing dimeric structures of MAOs, three-dimensional structure analysis of MAOB, overview Homo sapiens
1.4.3.4 More three-dimensional structure analysis of MAOA, overview Rattus norvegicus
1.4.3.4 More three-dimensional structure analysis of MAOB, overview Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
1.4.3.4 MAOA
-
 Homo sapiens
1.4.3.4 MAOA
-
 Rattus norvegicus
1.4.3.4 MAOB
-
 Homo sapiens
1.4.3.4 MAOB
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.3.4 flavin covalent flavin cofactor present in the MAO active sites Homo sapiens
1.4.3.4 flavin covalent flavin cofactor present in the MAO active sites Rattus norvegicus