EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
5.3.99.3 | microsome | - |
Mus musculus | - |
- |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
5.3.99.3 | Mus musculus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
5.3.99.3 | Lewis lung carcinoma cell | - |
Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.3.99.3 | Prostaglandin H2 | - |
Mus musculus | Prostaglandin E2 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
5.3.99.3 | microsomal prostaglandin E synthase-1 | - |
Mus musculus |
5.3.99.3 | mPGES-1 | - |
Mus musculus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
5.3.99.3 | malfunction | small interfering RNA silencing of mPGES-1 in Lewis lung carcinoma cells decreases prostaglandin E2 synthesis markedly, accompanied by reduced cell proliferation, attenuated Matrigel invasiveness and increased extracellular matrix adhesion, while mPGES-1-overexpression shows increased proliferating and invasive capacities | Mus musculus |