BRENDA - Enzyme Database

Inhibitory effects of kynurenic acid, a tryptophan metabolite, and its derivatives on cytosolic sulfotransferases

Senggunprai, L.; Yoshinari, K.; Yamazoe, Y.; Biochem. J. 422, 455-462 (2009)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
2.8.2.1
expressed in Escherichia coli BL21(DE3) cells; expressed in Escherichia coli BL21(DE3) cells
Homo sapiens
2.8.2.1
expressed in Escherichia coli BL21(DE3) cells; expressed in Escherichia coli BL21(DE3) cells
Mus musculus
2.8.2.3
expressed in Escherichia coli BL21(DE3) cells
Mus musculus
2.8.2.4
expressed in Escherichia coli BL21(DE3) cells
Homo sapiens
2.8.2.14
expressed in Escherichia coli BL21(DE3) cells
Homo sapiens
2.8.2.15
expressed in Escherichia coli BL21(DE3) cells
Mus musculus
2.8.2.15
expressed in Escherichia coli BL21(DE3) cells
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.8.2.1
2,6-Dichloro-4-nitrophenol
; non-specific SULT inhibitor
Homo sapiens
2.8.2.1
2,6-Dichloro-4-nitrophenol
non-specific SULT inhibitor; non-specific SULT inhibitor
Mus musculus
2.8.2.1
5,7-dichlorokynurenic acid
;
Homo sapiens
2.8.2.1
5,7-dichlorokynurenic acid
;
Mus musculus
2.8.2.1
gavestinel
i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt; i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt
Homo sapiens
2.8.2.1
gavestinel
i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt; i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt
Mus musculus
2.8.2.1
Kynurenic acid
;
Homo sapiens
2.8.2.1
Kynurenic acid
; exhibits selective inhibitory effects on Sult1b1-mediated sulfation of various compounds with IC50 values in the low micromolar range,
Mus musculus
2.8.2.1
L689,560
i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline; i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline
Homo sapiens
2.8.2.1
L689,560
i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline; i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline
Mus musculus
2.8.2.1
L701,324
i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone; i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone
Homo sapiens
2.8.2.1
L701,324
i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone; i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone
Mus musculus
2.8.2.1
Mefenamic acid
;
Homo sapiens
2.8.2.1
Mefenamic acid
;
Mus musculus
2.8.2.3
5,7-dichlorokynurenic acid
-
Mus musculus
2.8.2.3
gavestinel
i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt
Mus musculus
2.8.2.3
Kynurenic acid
-
Mus musculus
2.8.2.3
L689,560
i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline
Mus musculus
2.8.2.3
L701,324
i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone
Mus musculus
2.8.2.3
Mefenamic acid
-
Mus musculus
2.8.2.4
5,7-dichlorokynurenic acid
-
Homo sapiens
2.8.2.4
gavestinel
i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt
Homo sapiens
2.8.2.4
Kynurenic acid
-
Homo sapiens
2.8.2.4
L689,560
i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline
Homo sapiens
2.8.2.4
L701,324
i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone
Homo sapiens
2.8.2.4
Mefenamic acid
-
Homo sapiens
2.8.2.14
2,6-Dichloro-4-nitrophenol
non-specific SULT inhibitor
Homo sapiens
2.8.2.14
5,7-dichlorokynurenic acid
-
Homo sapiens
2.8.2.14
gavestinel
i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt
Homo sapiens
2.8.2.14
Kynurenic acid
-
Homo sapiens
2.8.2.14
L689,560
i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline
Homo sapiens
2.8.2.14
L701,324
i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone
Homo sapiens
2.8.2.14
Mefenamic acid
-
Homo sapiens
2.8.2.15
2,6-Dichloro-4-nitrophenol
non-specific SULT inhibitor
Homo sapiens
2.8.2.15
5,7-dichlorokynurenic acid
-
Homo sapiens
2.8.2.15
5,7-dichlorokynurenic acid
-
Mus musculus
2.8.2.15
gavestinel
i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt
Homo sapiens
2.8.2.15
gavestinel
i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt
Mus musculus
2.8.2.15
Kynurenic acid
exhibits selective inhibitory effects on Sult1b1-mediated sulfation of various compounds with IC50 values in the low micromolar range
Homo sapiens
2.8.2.15
Kynurenic acid
-
Mus musculus
2.8.2.15
L689,560
i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline
Homo sapiens
2.8.2.15
L689,560
i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline
Mus musculus
2.8.2.15
L701,324
i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone
Homo sapiens
2.8.2.15
L701,324
i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone
Mus musculus
2.8.2.15
Mefenamic acid
-
Homo sapiens
2.8.2.15
Mefenamic acid
-
Mus musculus
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.8.2.1
0.00035
-
p-nitrophenol
isoform Sult1a1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
2.8.2.1
0.00041
-
4-nitrophenol
isoform Sult1a1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
2.8.2.1
0.00053
-
xanthurenic acid
isoform SULT1B1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
2.8.2.1
0.00099
-
1-naphthol
isoform Sult1a1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
2.8.2.1
0.0026
-
beta-estradiol
isoform Sult1a1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
2.8.2.1
0.0053
-
dopamine
isoform SULT1A3, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
2.8.2.1
0.0433
-
xanthurenic acid
isoform Sult1a1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
2.8.2.1
0.0509
-
xanthurenic acid
isoform Sult1a1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
2.8.2.1
0.0529
-
p-nitrophenol
isoform SULT1B1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
2.8.2.1
0.0939
-
L-triiodothyronine
isoform SULT1B1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
2.8.2.4
0.00033
-
beta-estradiol
isoform SULT1E1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
2.8.2.14
0.0014
-
dehydroepiandrosterone
isoform SULT2A1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
2.8.2.15
0.0012
-
1-naphthol
isoform SULT1B1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
2.8.2.15
0.0051
-
dehydroepiandrosterone
isoform SULT2A1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
2.8.2.15
0.0063
-
xanthurenic acid
isoform SULT1B1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
2.8.2.15
0.015
-
xanthurenic acid
isoform Sult1d1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
2.8.2.15
0.0209
-
3,4-dihydroxyphenylacetic acid
isoform Sult1d1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
2.8.2.15
0.0399
-
4-nitrophenol
isoform SULT1B1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
2.8.2.15
0.145
-
L-triiodothyronine
isoform SULT1B1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
2.8.2.15
0.206
-
xanthurenic acid
isoform SULT1C2, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
2.8.2.15
0.238
-
3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-amine
isoform Sult2a1, in 50 mM Tris/HCl buffer, pH 10.0, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.8.2.1
cytosol
;
Homo sapiens
5829
-
2.8.2.1
cytosol
;
Mus musculus
5829
-
2.8.2.3
cytosol
-
Mus musculus
5829
-
2.8.2.4
cytosol
-
Homo sapiens
5829
-
2.8.2.14
cytosol
-
Homo sapiens
5829
-
2.8.2.15
cytosol
-
Mus musculus
5829
-
2.8.2.15
cytosol
-
Homo sapiens
5829
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.8.2.1
3'-phosphoadenylyl sulfate + 1-naphthol
Mus musculus
-
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + 1-naphthol
Homo sapiens
-
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + 4-nitrophenol
Mus musculus
-
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + 4-nitrophenol
Homo sapiens
-
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + beta-estradiol
Mus musculus
-
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + beta-estradiol
Homo sapiens
-
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + desipramine
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + desipramine
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + L-triiodothyronine
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + L-triiodothyronine
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + xanthurenic acid
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + xanthurenic acid
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.3
3'-phosphoadenylyl sulfate + 1-naphthol
Mus musculus
-
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
?
2.8.2.3
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.3
3'-phosphoadenylyl sulfate + 4-nitrophenol
Mus musculus
-
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
?
2.8.2.3
3'-phosphoadenylyl sulfate + beta-estradiol
Mus musculus
-
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
?
2.8.2.3
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.3
3'-phosphoadenylyl sulfate + desipramine
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.3
3'-phosphoadenylyl sulfate + L-triiodothyronine
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.3
3'-phosphoadenylyl sulfate + xanthurenic acid
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.4
3'-phosphoadenylyl sulfate + 1-naphthol
Homo sapiens
-
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
?
2.8.2.4
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.4
3'-phosphoadenylyl sulfate + 4-nitrophenol
Homo sapiens
-
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
?
2.8.2.4
3'-phosphoadenylyl sulfate + beta-estradiol
Homo sapiens
-
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
?
2.8.2.4
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.4
3'-phosphoadenylyl sulfate + desipramine
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.4
3'-phosphoadenylyl sulfate + L-triiodothyronine
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.4
3'-phosphoadenylyl sulfate + xanthurenic acid
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.14
3'-phosphoadenylyl sulfate + 1-naphthol
Homo sapiens
-
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
?
2.8.2.14
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.14
3'-phosphoadenylyl sulfate + 4-nitrophenol
Homo sapiens
-
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
?
2.8.2.14
3'-phosphoadenylyl sulfate + beta-estradiol
Homo sapiens
-
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
?
2.8.2.14
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.14
3'-phosphoadenylyl sulfate + desipramine
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.14
3'-phosphoadenylyl sulfate + L-triiodothyronine
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.14
3'-phosphoadenylyl sulfate + xanthurenic acid
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + 1-naphthol
Mus musculus
-
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + 1-naphthol
Homo sapiens
-
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + 4-nitrophenol
Mus musculus
-
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + 4-nitrophenol
Homo sapiens
-
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + beta-estradiol
Mus musculus
-
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + beta-estradiol
Homo sapiens
-
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + desipramine
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + desipramine
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + L-triiodothyronine
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + L-triiodothyronine
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + xanthurenic acid
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + xanthurenic acid
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.8.2.1
Homo sapiens
P0DMM9
-
-
2.8.2.1
Homo sapiens
P50225
-
-
2.8.2.1
Mus musculus
-
-
-
2.8.2.1
Mus musculus
Q9QWG7
-
-
2.8.2.3
Mus musculus
-
-
-
2.8.2.4
Homo sapiens
P49888
-
-
2.8.2.14
Homo sapiens
Q06520
-
-
2.8.2.15
Homo sapiens
-
-
-
2.8.2.15
Mus musculus
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
2.8.2.1
Ni-NTA agarose column chromatography; Ni-NTA agarose column chromatography
Homo sapiens
2.8.2.1
Ni-NTA agarose column chromatography; Ni-NTA agarose column chromatography
Mus musculus
2.8.2.3
Ni-NTA agarose column chromatography
Mus musculus
2.8.2.4
Ni-NTA agarose column chromatography
Homo sapiens
2.8.2.14
Ni-NTA agarose column chromatography
Homo sapiens
2.8.2.15
Ni-NTA agarose column chromatography
Homo sapiens
2.8.2.15
Ni-NTA agarose column chromatography
Mus musculus
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.8.2.1
3'-phosphoadenylyl sulfate + 1-naphthol
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + 1-naphthol
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + 4-nitrophenol
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + 4-nitrophenol
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + beta-estradiol
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + beta-estradiol
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + desipramine
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + desipramine
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + L-triiodothyronine
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + L-triiodothyronine
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + xanthurenic acid
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + xanthurenic acid
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.3
3'-phosphoadenylyl sulfate + 1-naphthol
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
-
?
2.8.2.3
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.3
3'-phosphoadenylyl sulfate + 4-nitrophenol
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
?
2.8.2.3
3'-phosphoadenylyl sulfate + beta-estradiol
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
-
?
2.8.2.3
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.3
3'-phosphoadenylyl sulfate + desipramine
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.3
3'-phosphoadenylyl sulfate + L-triiodothyronine
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.3
3'-phosphoadenylyl sulfate + xanthurenic acid
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.4
3'-phosphoadenylyl sulfate + 1-naphthol
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
-
?
2.8.2.4
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.4
3'-phosphoadenylyl sulfate + 4-nitrophenol
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
?
2.8.2.4
3'-phosphoadenylyl sulfate + beta-estradiol
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
-
?
2.8.2.4
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.4
3'-phosphoadenylyl sulfate + desipramine
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.4
3'-phosphoadenylyl sulfate + L-triiodothyronine
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.4
3'-phosphoadenylyl sulfate + xanthurenic acid
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.14
3'-phosphoadenylyl sulfate + 1-naphthol
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
-
?
2.8.2.14
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.14
3'-phosphoadenylyl sulfate + 4-nitrophenol
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
?
2.8.2.14
3'-phosphoadenylyl sulfate + beta-estradiol
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
-
?
2.8.2.14
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.14
3'-phosphoadenylyl sulfate + desipramine
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.14
3'-phosphoadenylyl sulfate + L-triiodothyronine
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.14
3'-phosphoadenylyl sulfate + xanthurenic acid
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + 1-naphthol
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + 1-naphthol
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + 4-nitrophenol
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + 4-nitrophenol
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + beta-estradiol
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + beta-estradiol
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + desipramine
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + desipramine
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + L-triiodothyronine
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + L-triiodothyronine
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + xanthurenic acid
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + xanthurenic acid
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
IC50 Value
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
2.8.2.1
0.00002
-
isoform Sult1a1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
2,6-Dichloro-4-nitrophenol
2.8.2.1
0.00017
-
isoform Sult1a1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
2,6-Dichloro-4-nitrophenol
2.8.2.1
0.00039
-
isoform Sult1a1, using 4-nitrophenol as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
2,6-Dichloro-4-nitrophenol
2.8.2.1
0.0004
-
isoform Sult1a1, using 4-nitrophenol as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
2,6-Dichloro-4-nitrophenol
2.8.2.1
0.00072
-
isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
gavestinel
2.8.2.1
0.00092
-
isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
gavestinel
2.8.2.1
0.003
-
isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C; isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
Kynurenic acid
2.8.2.1
0.0049
-
isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C; isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
Kynurenic acid
2.8.2.1
0.005
-
IC50 above 0.005 mM, isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C; IC50 above 0.005 mM, isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
Mefenamic acid
2.8.2.1
0.0106
-
isoform Sult1a1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
gavestinel
2.8.2.1
0.0137
-
isoform Sult1a1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
5,7-dichlorokynurenic acid
2.8.2.1
0.0149
-
isoform Sult1a1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
Mefenamic acid
2.8.2.1
0.018
-
isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
2,6-Dichloro-4-nitrophenol
2.8.2.1
0.0188
-
isoform Sult1a1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
Kynurenic acid
2.8.2.1
0.0208
-
IC50 above 1.0 mM, isoform SULT1A1, using 4-nitrophenol as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
5,7-dichlorokynurenic acid
2.8.2.1
0.022
-
isoform Sult1a1, using 4-nitrophenol as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
Kynurenic acid
2.8.2.1
0.0304
-
isoform Sult1a1, using 4-nitrophenol as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
Mefenamic acid
2.8.2.1
0.0372
-
isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
2,6-Dichloro-4-nitrophenol
2.8.2.1
0.0696
-
isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
5,7-dichlorokynurenic acid
2.8.2.1
0.0986
-
isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
5,7-dichlorokynurenic acid
2.8.2.1
0.117
-
isoform Sult1a1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
L689,560
2.8.2.1
0.1663
-
isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
L689,560
2.8.2.1
0.1796
-
isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
L689,560
2.8.2.1
0.25
-
IC50 above 0.25 mM, isoform Sult1a1, using 4-nitrophenol as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C; IC50 above 0.25 mM, isoform Sult1a1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
Kynurenic acid
2.8.2.1
0.25
-
IC50 above 0.25 mM, isoform Sult1a1, using 4-nitrophenol as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
L689,560
2.8.2.1
146
-
IC50 above 0.25 mM, isoform Sult1a1, using 4-nitrophenol as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
gavestinel
2.8.2.15
0.0012
-
isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
gavestinel
2.8.2.15
0.0017
-
isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
gavestinel
2.8.2.15
0.005
-
IC50 above 0.005 mM, isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C; IC50 above 0.005 mM, isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
Mefenamic acid
2.8.2.15
0.0337
-
isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
Kynurenic acid
2.8.2.15
0.0342
-
isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
2,6-Dichloro-4-nitrophenol
2.8.2.15
0.0473
-
isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
L689,560
2.8.2.15
0.0536
-
isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
L689,560
2.8.2.15
0.1642
-
isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
5,7-dichlorokynurenic acid
2.8.2.15
0.2536
-
isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
5,7-dichlorokynurenic acid
2.8.2.15
9
-
isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
Kynurenic acid
2.8.2.15
24
-
isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
2,6-Dichloro-4-nitrophenol
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
2.8.2.1
expressed in Escherichia coli BL21(DE3) cells
Homo sapiens
2.8.2.1
expressed in Escherichia coli BL21(DE3) cells
Mus musculus
2.8.2.3
expressed in Escherichia coli BL21(DE3) cells
Mus musculus
2.8.2.4
expressed in Escherichia coli BL21(DE3) cells
Homo sapiens
2.8.2.14
expressed in Escherichia coli BL21(DE3) cells
Homo sapiens
2.8.2.15
expressed in Escherichia coli BL21(DE3) cells
Mus musculus
2.8.2.15
expressed in Escherichia coli BL21(DE3) cells
Homo sapiens
IC50 Value (protein specific)
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
2.8.2.1
0.00002
-
isoform Sult1a1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
2,6-Dichloro-4-nitrophenol
2.8.2.1
0.00017
-
isoform Sult1a1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
2,6-Dichloro-4-nitrophenol
2.8.2.1
0.00039
-
isoform Sult1a1, using 4-nitrophenol as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
2,6-Dichloro-4-nitrophenol
2.8.2.1
0.0004
-
isoform Sult1a1, using 4-nitrophenol as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
2,6-Dichloro-4-nitrophenol
2.8.2.1
0.00072
-
isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
gavestinel
2.8.2.1
0.00092
-
isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
gavestinel
2.8.2.1
0.003
-
isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
Kynurenic acid
2.8.2.1
0.0049
-
isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
Kynurenic acid
2.8.2.1
0.005
-
IC50 above 0.005 mM, isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C; IC50 above 0.005 mM, isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
Mefenamic acid
2.8.2.1
0.0106
-
isoform Sult1a1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
gavestinel
2.8.2.1
0.0137
-
isoform Sult1a1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
5,7-dichlorokynurenic acid
2.8.2.1
0.0149
-
isoform Sult1a1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
Mefenamic acid
2.8.2.1
0.018
-
isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
2,6-Dichloro-4-nitrophenol
2.8.2.1
0.0188
-
isoform Sult1a1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
Kynurenic acid
2.8.2.1
0.0208
-
IC50 above 1.0 mM, isoform SULT1A1, using 4-nitrophenol as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
5,7-dichlorokynurenic acid
2.8.2.1
0.022
-
isoform Sult1a1, using 4-nitrophenol as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
Kynurenic acid
2.8.2.1
0.0304
-
isoform Sult1a1, using 4-nitrophenol as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
Mefenamic acid
2.8.2.1
0.0372
-
isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
2,6-Dichloro-4-nitrophenol
2.8.2.1
0.0696
-
isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
5,7-dichlorokynurenic acid
2.8.2.1
0.0986
-
isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
5,7-dichlorokynurenic acid
2.8.2.1
0.117
-
isoform Sult1a1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
L689,560
2.8.2.1
0.1663
-
isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
L689,560
2.8.2.1
0.1796
-
isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
L689,560
2.8.2.1
0.25
-
IC50 above 0.25 mM, isoform Sult1a1, using 4-nitrophenol as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C; IC50 above 0.25 mM, isoform Sult1a1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
Kynurenic acid
2.8.2.1
0.25
-
IC50 above 0.25 mM, isoform Sult1a1, using 4-nitrophenol as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
L689,560
2.8.2.1
146
-
IC50 above 0.25 mM, isoform Sult1a1, using 4-nitrophenol as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
gavestinel
2.8.2.15
0.0012
-
isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
gavestinel
2.8.2.15
0.0017
-
isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
gavestinel
2.8.2.15
0.005
-
IC50 above 0.005 mM, isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C; IC50 above 0.005 mM, isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
Mefenamic acid
2.8.2.15
0.0337
-
isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
Kynurenic acid
2.8.2.15
0.0342
-
isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
2,6-Dichloro-4-nitrophenol
2.8.2.15
0.0473
-
isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
L689,560
2.8.2.15
0.0536
-
isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
L689,560
2.8.2.15
0.1642
-
isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
5,7-dichlorokynurenic acid
2.8.2.15
0.2536
-
isoform SULT1B1, using xanthurenic acid as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
5,7-dichlorokynurenic acid
2.8.2.15
9
-
isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
Kynurenic acid
2.8.2.15
24
-
isoform SULT1B1, using L-triiodothyronine as substrate, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
2,6-Dichloro-4-nitrophenol
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.8.2.1
2,6-Dichloro-4-nitrophenol
-
Homo sapiens
2.8.2.1
2,6-Dichloro-4-nitrophenol
non-specific SULT inhibitor
Homo sapiens
2.8.2.1
2,6-Dichloro-4-nitrophenol
non-specific SULT inhibitor
Mus musculus
2.8.2.1
5,7-dichlorokynurenic acid
-
Homo sapiens
2.8.2.1
5,7-dichlorokynurenic acid
-
Mus musculus
2.8.2.1
gavestinel
i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt
Homo sapiens
2.8.2.1
gavestinel
i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt
Mus musculus
2.8.2.1
Kynurenic acid
-
Homo sapiens
2.8.2.1
Kynurenic acid
-
Mus musculus
2.8.2.1
Kynurenic acid
exhibits selective inhibitory effects on Sult1b1-mediated sulfation of various compounds with IC50 values in the low micromolar range,
Mus musculus
2.8.2.1
L689,560
i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline
Homo sapiens
2.8.2.1
L689,560
i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline
Mus musculus
2.8.2.1
L701,324
i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone
Homo sapiens
2.8.2.1
L701,324
i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone
Mus musculus
2.8.2.1
Mefenamic acid
-
Homo sapiens
2.8.2.1
Mefenamic acid
-
Mus musculus
2.8.2.3
5,7-dichlorokynurenic acid
-
Mus musculus
2.8.2.3
gavestinel
i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt
Mus musculus
2.8.2.3
Kynurenic acid
-
Mus musculus
2.8.2.3
L689,560
i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline
Mus musculus
2.8.2.3
L701,324
i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone
Mus musculus
2.8.2.3
Mefenamic acid
-
Mus musculus
2.8.2.4
5,7-dichlorokynurenic acid
-
Homo sapiens
2.8.2.4
gavestinel
i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt
Homo sapiens
2.8.2.4
Kynurenic acid
-
Homo sapiens
2.8.2.4
L689,560
i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline
Homo sapiens
2.8.2.4
L701,324
i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone
Homo sapiens
2.8.2.4
Mefenamic acid
-
Homo sapiens
2.8.2.14
2,6-Dichloro-4-nitrophenol
non-specific SULT inhibitor
Homo sapiens
2.8.2.14
5,7-dichlorokynurenic acid
-
Homo sapiens
2.8.2.14
gavestinel
i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt
Homo sapiens
2.8.2.14
Kynurenic acid
-
Homo sapiens
2.8.2.14
L689,560
i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline
Homo sapiens
2.8.2.14
L701,324
i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone
Homo sapiens
2.8.2.14
Mefenamic acid
-
Homo sapiens
2.8.2.15
2,6-Dichloro-4-nitrophenol
non-specific SULT inhibitor
Homo sapiens
2.8.2.15
5,7-dichlorokynurenic acid
-
Homo sapiens
2.8.2.15
5,7-dichlorokynurenic acid
-
Mus musculus
2.8.2.15
gavestinel
i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt
Homo sapiens
2.8.2.15
gavestinel
i.e. 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-1H-indole-2-carboxylic acid sodium salt
Mus musculus
2.8.2.15
Kynurenic acid
exhibits selective inhibitory effects on Sult1b1-mediated sulfation of various compounds with IC50 values in the low micromolar range
Homo sapiens
2.8.2.15
Kynurenic acid
-
Mus musculus
2.8.2.15
L689,560
i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline
Homo sapiens
2.8.2.15
L689,560
i.e. trans-2-carboxy-5,7-dichloro-4-phenylaminocarboxylamino-1,2,3,4-tetrahydroquinoline
Mus musculus
2.8.2.15
L701,324
i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone
Homo sapiens
2.8.2.15
L701,324
i.e. 7-chloro-4-hydroxy-3(3-phenoxy)phenyl-2(H)-quinolinone
Mus musculus
2.8.2.15
Mefenamic acid
-
Homo sapiens
2.8.2.15
Mefenamic acid
-
Mus musculus
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.8.2.1
0.00035
-
p-nitrophenol
isoform Sult1a1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
2.8.2.1
0.00041
-
4-nitrophenol
isoform Sult1a1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
2.8.2.1
0.00053
-
xanthurenic acid
isoform SULT1B1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
2.8.2.1
0.00099
-
1-naphthol
isoform Sult1a1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
2.8.2.1
0.0026
-
beta-estradiol
isoform Sult1a1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
2.8.2.1
0.0053
-
dopamine
isoform SULT1A3, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
2.8.2.1
0.0433
-
xanthurenic acid
isoform Sult1a1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
2.8.2.1
0.0509
-
xanthurenic acid
isoform Sult1a1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
2.8.2.1
0.0529
-
p-nitrophenol
isoform SULT1B1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
2.8.2.1
0.0939
-
L-triiodothyronine
isoform SULT1B1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
2.8.2.4
0.00033
-
beta-estradiol
isoform SULT1E1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
2.8.2.14
0.0014
-
dehydroepiandrosterone
isoform SULT2A1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
2.8.2.15
0.0012
-
1-naphthol
isoform SULT1B1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
2.8.2.15
0.0051
-
dehydroepiandrosterone
isoform SULT2A1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
2.8.2.15
0.0063
-
xanthurenic acid
isoform SULT1B1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
2.8.2.15
0.015
-
xanthurenic acid
isoform Sult1d1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
2.8.2.15
0.0209
-
3,4-dihydroxyphenylacetic acid
isoform Sult1d1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
2.8.2.15
0.0399
-
4-nitrophenol
isoform SULT1B1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
2.8.2.15
0.145
-
L-triiodothyronine
isoform SULT1B1, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
2.8.2.15
0.206
-
xanthurenic acid
isoform SULT1C2, in 50 mM Tris/HCl buffer, pH 7.4, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Homo sapiens
2.8.2.15
0.238
-
3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-amine
isoform Sult2a1, in 50 mM Tris/HCl buffer, pH 10.0, 1 mM dithiothreitol, 5 mM MgCl2, and 1 mg/ml bovine serum albumin, at 37°C
Mus musculus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.8.2.1
cytosol
-
Mus musculus
5829
-
2.8.2.1
cytosol
-
Homo sapiens
5829
-
2.8.2.3
cytosol
-
Mus musculus
5829
-
2.8.2.4
cytosol
-
Homo sapiens
5829
-
2.8.2.14
cytosol
-
Homo sapiens
5829
-
2.8.2.15
cytosol
-
Homo sapiens
5829
-
2.8.2.15
cytosol
-
Mus musculus
5829
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.8.2.1
3'-phosphoadenylyl sulfate + 1-naphthol
Mus musculus
-
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + 1-naphthol
Homo sapiens
-
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + 4-nitrophenol
Mus musculus
-
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + 4-nitrophenol
Homo sapiens
-
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + beta-estradiol
Mus musculus
-
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + beta-estradiol
Homo sapiens
-
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + desipramine
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + desipramine
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + L-triiodothyronine
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + L-triiodothyronine
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + xanthurenic acid
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + xanthurenic acid
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.3
3'-phosphoadenylyl sulfate + 1-naphthol
Mus musculus
-
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
?
2.8.2.3
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.3
3'-phosphoadenylyl sulfate + 4-nitrophenol
Mus musculus
-
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
?
2.8.2.3
3'-phosphoadenylyl sulfate + beta-estradiol
Mus musculus
-
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
?
2.8.2.3
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.3
3'-phosphoadenylyl sulfate + desipramine
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.3
3'-phosphoadenylyl sulfate + L-triiodothyronine
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.3
3'-phosphoadenylyl sulfate + xanthurenic acid
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.4
3'-phosphoadenylyl sulfate + 1-naphthol
Homo sapiens
-
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
?
2.8.2.4
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.4
3'-phosphoadenylyl sulfate + 4-nitrophenol
Homo sapiens
-
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
?
2.8.2.4
3'-phosphoadenylyl sulfate + beta-estradiol
Homo sapiens
-
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
?
2.8.2.4
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.4
3'-phosphoadenylyl sulfate + desipramine
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.4
3'-phosphoadenylyl sulfate + L-triiodothyronine
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.4
3'-phosphoadenylyl sulfate + xanthurenic acid
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.14
3'-phosphoadenylyl sulfate + 1-naphthol
Homo sapiens
-
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
?
2.8.2.14
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.14
3'-phosphoadenylyl sulfate + 4-nitrophenol
Homo sapiens
-
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
?
2.8.2.14
3'-phosphoadenylyl sulfate + beta-estradiol
Homo sapiens
-
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
?
2.8.2.14
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.14
3'-phosphoadenylyl sulfate + desipramine
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.14
3'-phosphoadenylyl sulfate + L-triiodothyronine
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.14
3'-phosphoadenylyl sulfate + xanthurenic acid
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + 1-naphthol
Mus musculus
-
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + 1-naphthol
Homo sapiens
-
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + 4-nitrophenol
Mus musculus
-
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + 4-nitrophenol
Homo sapiens
-
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + beta-estradiol
Mus musculus
-
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + beta-estradiol
Homo sapiens
-
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + desipramine
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + desipramine
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + L-triiodothyronine
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + L-triiodothyronine
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + xanthurenic acid
Mus musculus
-
adenosine 3',5'-bisphosphate + ?
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + xanthurenic acid
Homo sapiens
-
adenosine 3',5'-bisphosphate + ?
-
-
?
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
2.8.2.1
Ni-NTA agarose column chromatography
Homo sapiens
2.8.2.1
Ni-NTA agarose column chromatography
Mus musculus
2.8.2.3
Ni-NTA agarose column chromatography
Mus musculus
2.8.2.4
Ni-NTA agarose column chromatography
Homo sapiens
2.8.2.14
Ni-NTA agarose column chromatography
Homo sapiens
2.8.2.15
Ni-NTA agarose column chromatography
Homo sapiens
2.8.2.15
Ni-NTA agarose column chromatography
Mus musculus
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.8.2.1
3'-phosphoadenylyl sulfate + 1-naphthol
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + 1-naphthol
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + 4-nitrophenol
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + 4-nitrophenol
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + beta-estradiol
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + beta-estradiol
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + desipramine
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + desipramine
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + L-triiodothyronine
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + L-triiodothyronine
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + xanthurenic acid
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + xanthurenic acid
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.3
3'-phosphoadenylyl sulfate + 1-naphthol
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
-
?
2.8.2.3
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.3
3'-phosphoadenylyl sulfate + 4-nitrophenol
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
?
2.8.2.3
3'-phosphoadenylyl sulfate + beta-estradiol
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
-
?
2.8.2.3
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.3
3'-phosphoadenylyl sulfate + desipramine
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.3
3'-phosphoadenylyl sulfate + L-triiodothyronine
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.3
3'-phosphoadenylyl sulfate + xanthurenic acid
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.4
3'-phosphoadenylyl sulfate + 1-naphthol
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
-
?
2.8.2.4
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.4
3'-phosphoadenylyl sulfate + 4-nitrophenol
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
?
2.8.2.4
3'-phosphoadenylyl sulfate + beta-estradiol
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
-
?
2.8.2.4
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.4
3'-phosphoadenylyl sulfate + desipramine
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.4
3'-phosphoadenylyl sulfate + L-triiodothyronine
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.4
3'-phosphoadenylyl sulfate + xanthurenic acid
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.14
3'-phosphoadenylyl sulfate + 1-naphthol
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
-
?
2.8.2.14
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.14
3'-phosphoadenylyl sulfate + 4-nitrophenol
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
?
2.8.2.14
3'-phosphoadenylyl sulfate + beta-estradiol
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
-
?
2.8.2.14
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.14
3'-phosphoadenylyl sulfate + desipramine
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.14
3'-phosphoadenylyl sulfate + L-triiodothyronine
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.14
3'-phosphoadenylyl sulfate + xanthurenic acid
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + 1-naphthol
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + 1-naphthol
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + 1-naphthyl sulfate
-
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + 3,4-dihydroxyphenylacetic acid
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + 4-nitrophenol
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + 4-nitrophenol
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + beta-estradiol
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + beta-estradiol
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + beta-estradiol 3-sulfate
-
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + dehydroepiandrosterone
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + desipramine
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + desipramine
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + L-triiodothyronine
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + L-triiodothyronine
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + xanthurenic acid
-
702138
Mus musculus
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.15
3'-phosphoadenylyl sulfate + xanthurenic acid
-
702138
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?