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Literature summary extracted from

  • Henderson, L.M.; Nelson, P.J.; Henderson, L.
    Mammalian enzymes of trimethyllysine conversion to trimethylaminobutyrate (1982), Fed. Proc., 41, 2843-2847.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.11.8 dithiothreitol sparing as well as augmenting effect Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.11.8 alpha-N-Acetyltrimethyllysine
-
Bos taurus
1.14.11.8 citrate
-
Bos taurus
1.14.11.8 Hydroxytrimethyllysine 4 stereoisomers Bos taurus
1.14.11.8 isocitrate
-
Bos taurus
1.14.11.8 Lactate
-
Bos taurus
1.14.11.8 malonate
-
Bos taurus
1.14.11.8 p-chloromercuribenzoate
-
Bos taurus
1.14.11.8 succinate
-
Bos taurus
1.14.11.8 Zn2+
-
Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.11.8 0.13
-
N6,N6,N6-Trimethyl-L-lysine
-
Bos taurus
1.14.11.8 0.22
-
alpha-ketoglutarate
-
Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.11.8 mitochondrion
-
Bos taurus 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.11.8 Ca2+ no stimulation Bos taurus
1.14.11.8 Fe2+ required Bos taurus
1.14.11.8 Fe2+ preincubation with Fe2+ in absence of other cofactors inactivates (ascorbate or dithiothreitol prevents inactivation) Bos taurus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.11.8 52000
-
x * 52000 + x * 65000, SDS-PAGE Bos taurus
1.14.11.8 65000
-
x * 52000 + x * 65000, SDS-PAGE Bos taurus
1.14.11.8 180000
-
gel filtration Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.8 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.11.8 partial Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.11.8 kidney cortex (67%), medulla (33%) Bos taurus
-
1.14.11.8 liver
-
Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.11.8 additional information
-
-
Bos taurus

Storage Stability

EC Number Storage Stability Organism
1.14.11.8 0°C, half-life: 5 days Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.8 N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2 N6,N6, N6-trimethyl-L-lysine is epsilon-N-trimethyl-L-lysine Bos taurus 3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2
-
?

Subunits

EC Number Subunits Comment Organism
1.14.11.8 ? x * 52000 + x * 65000, SDS-PAGE Bos taurus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.11.8 37
-
assay at Bos taurus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.14.11.8
-
-
half-life: 5 days Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.11.8 6.8
-
assay at Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.11.8 ascorbate required Bos taurus