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Literature summary extracted from

  • Muralidharan, F.N.; Muralidharan, V.B.
    Phytanoyl-CoA ligase activity in rat liver (1986), Biochem. Int., 13, 123-130.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.2.1.24 AMP 11 mM, 50% inhibition Rattus norvegicus
6.2.1.24 iodoacetic acid 75 mM, 100% inhibition Rattus norvegicus
6.2.1.24 NEM 10 mM, 87% inhibition Rattus norvegicus
6.2.1.24 palmitic acid
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.2.1.24 0.0286
-
 phytanic acid
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.2.1.24 microsome
-
 Rattus norvegicus
-
-
6.2.1.24 mitochondrion
-
 Rattus norvegicus 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.2.1.24 Mg2+ absolutely required, optimal concentration: 60 mM, inhibition at high concentrations Rattus norvegicus
6.2.1.24 Mn2+ can replace Mg2+ at 5 mM, inhibition at high concentrations Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.24 Rattus norvegicus
-
 enzyme is different from long chain acyl-CoA ligase, EC 6.2.1.3
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.24 adipose tissue
-
 Rattus norvegicus
-
6.2.1.24 heart
-
 Rattus norvegicus
-
6.2.1.24 kidney
-
 Rattus norvegicus
-
6.2.1.24 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.24 ATP + phytanate + CoA
-
 Rattus norvegicus AMP + diphosphate + phytanoyl-CoA
-
 ?
6.2.1.24 CTP + phytanate + CoA low activity compared to ATP Rattus norvegicus CMP + diphosphate + phytanoyl-CoA
-
 ?
6.2.1.24 GTP + phytanate + CoA low activity compared to ATP Rattus norvegicus GMP + diphosphate + phytanoyl-CoA
-
 ?
6.2.1.24 ITP + phytanate + CoA low activity compared to ATP Rattus norvegicus IMP + diphosphate + phytanoyl-CoA
-
 ?
6.2.1.24 UTP + phytanate + CoA low activity compared to ATP Rattus norvegicus UMP + diphosphate + phytanoyl-CoA
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
6.2.1.24 45
-
 t1/2: 3-5 min Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.2.1.24 8.7
-
 Tris-HCl buffer Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
6.2.1.24 11
-
 AMP
-
 Rattus norvegicus