BRENDA - Enzyme Database show

Expression of thromboxane synthase, prostacyclin synthase and thromboxane receptor in atherosclerotic lesions: correlation with plaque composition

Cyrus, T.; Ding, T.; Pratico, D.; Atherosclerosis 208, 376-381 (2010)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.4
Prostaglandin H2
Mus musculus
-
Prostaglandin I2
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.4
Mus musculus
-
-
-
5.3.99.5
Mus musculus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.4
aorta
atherosclerotic aorta
Mus musculus
-
5.3.99.5
aorta
atherosclerotic aorta
Mus musculus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.4
Prostaglandin H2
-
701992
Mus musculus
Prostaglandin I2
-
-
-
?
5.3.99.5
prostaglandin H2
-
701992
Mus musculus
thromboxane A2 + ?
-
-
-
?
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.4
Prostaglandin H2
Mus musculus
-
Prostaglandin I2
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.4
aorta
atherosclerotic aorta
Mus musculus
-
5.3.99.5
aorta
atherosclerotic aorta
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.4
Prostaglandin H2
-
701992
Mus musculus
Prostaglandin I2
-
-
-
?
5.3.99.5
prostaglandin H2
-
701992
Mus musculus
thromboxane A2 + ?
-
-
-
?
Expression
EC Number
Organism
Commentary
Expression
5.3.99.4
Mus musculus
after 16 weeks the prostacyclin synthase mRNA levels are reduced
down
5.3.99.4
Mus musculus
after 8 weeks on fat diet, aortic arches from low-density lipoprotein receptor deficient, LDL r-KO, mice shows a significant increase in prostacyclin synthase levels
up
5.3.99.5
Mus musculus
after 8 and 16 weeks on the fat diet, aortic arches from low-density lipoprotein receptor deficient mice show a significant increase in TXAS mRNA level when compared with control
up
Expression (protein specific)
EC Number
Organism
Commentary
Expression
5.3.99.4
Mus musculus
after 16 weeks the prostacyclin synthase mRNA levels are reduced
down
5.3.99.4
Mus musculus
after 8 weeks on fat diet, aortic arches from low-density lipoprotein receptor deficient, LDL r-KO, mice shows a significant increase in prostacyclin synthase levels
up
5.3.99.5
Mus musculus
after 8 and 16 weeks on the fat diet, aortic arches from low-density lipoprotein receptor deficient mice show a significant increase in TXAS mRNA level when compared with control
up