BRENDA - Enzyme Database show

Mesenchymal stem cell-based gene therapy with prostacyclin synthase enhanced neovascularization in hindlimb ischemia

Ishii, M.; Numaguchi, Y.; Okumura, K.; Kubota, R.; Ma, X.; Murakami, R.; Naruse, K.; Murohara, T.; Atherosclerosis 206, 109-118 (2009)

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
5.3.99.4
medicine
sustained release of prostaglandin I2 enhances the proangiogenic function of mesenchymal stem cells and subsequent muscle cell regrowth in the ischemic tissue suggesting potential therapeutic benefits of cell-based gene therapy for critical limb ischemia
Rattus norvegicus
Cloned(Commentary)
EC Number
Commentary
Organism
5.3.99.4
GFP-tagged cDNA containing the full-length rat prostacyclin synthase gene is inserted into an adenoviral DNA construct for in vitro gene transfer to murine and human mesenchymal stem cells
Rattus norvegicus
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
5.3.99.4
52000
-
determined by SDS-PAGE and Western Blot analysis
Rattus norvegicus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.4
Prostaglandin H2
Rattus norvegicus
-
Prostaglandin I2
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.4
Rattus norvegicus
Q62969
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.4
Prostaglandin H2
-
701991
Rattus norvegicus
Prostaglandin I2
-
-
-
?
Application (protein specific)
EC Number
Application
Commentary
Organism
5.3.99.4
medicine
sustained release of prostaglandin I2 enhances the proangiogenic function of mesenchymal stem cells and subsequent muscle cell regrowth in the ischemic tissue suggesting potential therapeutic benefits of cell-based gene therapy for critical limb ischemia
Rattus norvegicus
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
5.3.99.4
GFP-tagged cDNA containing the full-length rat prostacyclin synthase gene is inserted into an adenoviral DNA construct for in vitro gene transfer to murine and human mesenchymal stem cells
Rattus norvegicus
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
5.3.99.4
52000
-
determined by SDS-PAGE and Western Blot analysis
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.4
Prostaglandin H2
Rattus norvegicus
-
Prostaglandin I2
-
-
?
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.4
Prostaglandin H2
-
701991
Rattus norvegicus
Prostaglandin I2
-
-
-
?